Navigation Links
A home for the microbiome
Date:8/19/2013

did make contact, it would cause some sort of immune response."

Nonetheless, when the researchers used advanced imaging approaches to survey colonic tissue in mice colonized with B. fragilis, they found a small population of microbes living in miniscule pocketsor cryptsin the colon. Nestled within the crypts, the bacteria are protected from the constant flow of material that passes through the GI tract. To test whether or not the CCF system regulated bacterial colonization within the crypts, the team injected mutant bacteriawithout the CCF systeminto the colons of sterile mice. Those bacteria were unable to colonize the crypts.

"There is something in that cryptand we don't know what it is yetthat normal B. fragilis can use to get a foothold via the CCF system," Mazmanian explains. "Finding the crypts is a huge advance in the field because it shows that bacteria do physically contact the host. And during all of the experiments that Melanie did, homeostasis, or a steady state, was maintained. So, contrary to popular belief, there was no evidence of inflammation as a result of the bacteria contacting the host. In fact, we believe these crypts are the permanent home of Bacteroides, and perhaps other classes of microbes."

He says that by pinpointing the CCF system as a mechanism for bacterial colonization and resilience, in addition to the discovery of crypts in the colon that are species specific, the current paper has solved longstanding mysteries in the field about how microbes establish and maintain long-term colonization.

"We've studied only a handful of organisms, and though they are numerically abundant, they are clearly not representative of all the organisms in the gut," Lee says. "A lot of those other bacteria don't have CCF genes, so the question now is: Do those organisms somehow rely on interactions with Bacteroides for their own colonization, or their replication rates, or their localization?"
'/>"/>

Contact: Brian Bell
bpbell@caltech.edu
626-395-5832
California Institute of Technology
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. New gut microbiome research to explore red meat -- colorectal cancer pathway
2. Circumcision alters penis microbiome, could explain HIV protection
3. What impact does a day of roller derby have on our skin microbiome?
4. Genome scientists launch Microbiome journal
5. Manipulating the microbiome could help manage weight
6. Berkeley Lab scientists help define the healthy human microbiome
7. IU role in Human Microbiome Project exposes battle history between bacteria, viruses in human body
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... National Institutes of Health (NIH) awarded Lawrence Livermore ... an electrode array system that will enable researchers ... unprecedented resolution and scale. , LLNL,s grant-funded project ... Obama,s BRAIN (Brain Research through Advancing Innovative ... revolutionize our understanding of the human mind and ...
(Date:9/30/2014)... professor and Howard Hughes Medical Institute investigator, and ... recipients in the 2014 round of grants from ... BRAIN (Brain Research through Advancing Innovative Neurotechnologies) Initiative ... September 30, provides more than $3 million in ... , The BRAIN Initiative, launched last year, is ...
(Date:9/30/2014)... of environmental scientists and engineers, led by Clemson ... three-year, $5.25 million grant from the U.S. Department ... to make a direct positive impact on South ... disposal of radioactive contaminants. , "Understanding the scientific ... with environmental aspects of nuclear technologies is imperative ...
Breaking Biology News(10 mins):NIH taps lab to develop sophisticated electrode array system to monitor brain act 2NIH taps lab to develop sophisticated electrode array system to monitor brain act 3Salk scientists receive $3 million for BRAIN Initiative grant 2Researchers get $5.25 million to advance nuclear technologies in South Carolina 2
... produce increases, vegetable and fruit producers are facing ... challenged to examine traditional production practices in order ... A recent focus on both the positive and ... the globe working to find methods that can ...
... Motor commands issued by the brain to activate arm ... led by Professor Silvia Arber at the University of ... Research has now discovered, many neurons in the spinal ... but at the same time also back to the ...
... Drosophila (fruit fly) can be synchronised using vibrations, ... . The results suggest that an animal,s own movements can ... daily rhythms characterising most of our bodily functions including the ... and temperature. Researchers at UCL and Queen Mary, University ...
Cached Biology News:Nitrogen management studied in greenhouse pepper production 2Cc to the brain: How neurons control fine motor behavior of the arm 2Cc to the brain: How neurons control fine motor behavior of the arm 3
(Date:9/30/2014)... -- The overall research objective was to capture ... use. Most researchers outsource NGS technologies; however, in-house ... the next 12 months. Data accuracy and operating ... instruments. Disease-related research is the dominant use for ... surge, with half of the respondents planning to ...
(Date:9/30/2014)... CT (PRWEB) September 30, 2014 ... of scientific research products, recently opened an online ... comprehensive cell culture product lines developed and manufactured ... its online store include Biological Industries’ Nutristem® serum-free, ... and human embryonic stem cell (hESC) culture. ...
(Date:9/30/2014)... 30, 2014 Back in the 1970’s, many ... feet. per employee, which included space for circulation and file ... Jeff Howell, partner at Nidea Corporate Real Estate / ... “By the year 2000, however, 250 square feet per ... number come down to 175 to 225 square feet, and ...
(Date:9/29/2014)... conflicts in Iraq and Afghanistan, more than 300,000 soldiers ... injury caused by exposure to bomb blasts and ... Symptoms of traumatic brain injury can range from the ... severe impairments in memory and cognition. , Since ... critical importance and complexity of this problem, and has ...
Breaking Biology Technology:Global Next-generation Sequencing Trends 2Rainbow Scientific, Inc. opens online store for state-of-the-art stem cell culture and cytogenetic reagents 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 3Modeling shockwaves through the brain 2Modeling shockwaves through the brain 3Modeling shockwaves through the brain 4
... Sequella, Inc., a clinical-stage biopharmaceutical company focused on ... today announced that it received a $594,661 two-year ... National Institutes of Health (NIH), National Institute of ... of SQ641, Sequella,s lead compound in its capuramycin ...
... Dr. Michael Merzenich , PhD - ... plasticity expert and tech entrepreneur - was formally ... D.C. Also a member of the National Academy of Sciences, ... and doctors in the U.S. who have been selected for ...
... CITY, England, October 12 , ... and Milestones Plus,Royalties , Heptares Therapeutics ... announced today that it has,entered into an option agreement with ... StaR(TM) technology to generate novel,drug leads against a nominated, unspecified ...
Cached Biology Technology:Sequella Obtains Funding to Continue Expansion of its Anti-infectives Pipeline 2Sequella Obtains Funding to Continue Expansion of its Anti-infectives Pipeline 3Dr. Michael Merzenich Joins Venerable Short List Honored for Cutting-Edge Neuroscientific Research 2Dr. Michael Merzenich Joins Venerable Short List Honored for Cutting-Edge Neuroscientific Research 3Heptares Therapeutics Announces Agreement With Novartis Option Fund to Apply its StaR(TM) Technology and Generate Novel Drug Leads Against a GPCR Target 2Heptares Therapeutics Announces Agreement With Novartis Option Fund to Apply its StaR(TM) Technology and Generate Novel Drug Leads Against a GPCR Target 3
... The Zero Blunt TOPO ... Sequencing is designed for ... of blunt-end PCR products. ... 5-minute TOPO Cloning and ...
... Blunt TOPO PCR Cloning ... designed for cloning and ... PCR products. The pCR4Blunt-TOPO ... Cloning and greater than ...
... EA. Ultrospec 6300 pro UV/Visible ... the Pharmacopoeia in terms of instrument specification ... being able to be used for rapid, ... excellent scanning capability., *Press to read high ...
...
Biology Products: