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A heart of gold
Date:7/17/2013

ir own connectors once more.

New tissues are created by placing cells taken from patients or animals onto a three-dimensional scaffolding made of biomaterials any matter or surface that interacts with biological systems which organize the cells into the proper formation as they grow. Dr. Dvir and his team used various chemical and physical processes to integrate gold nanoparticles into their scaffolds. The cells then interacted with each other through these gold nanoparticles.

The researchers used a scanning electron microscope and various measures of electrical activity in order to observe the nanoparticles on the fibers and check conductivity. Cells placed on the gold-embedded scaffolding had significantly stronger contractions compared to those on a scaffolding without gold. Importantly, the cells contracted in unison, demonstrating effective electrical signalling between them.

A golden opportunity

Because 50 percent of heart attack victims die within five years of their initial attack, new treatment options are sorely needed. A functioning, transplantable tissue could not only save lives, but improve a patient's quality of life overall.

Having demonstrated the electrical signalling capability of these gold infused cardiac patches, Dr. Dvir will next evaluate their potential to improve function after heart attack through pre-clinical tests in the lab and, eventually, clinical trials with patients. He says that the ideal method would be to use a patient's own cells when building the new tissue, therefore avoiding the risk of rejection.


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Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert

Page: 1 2

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