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A 'heart healthy' diet and ongoing, moderate physical activity may protect against cognitive decline
Date:7/14/2009

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"Our results suggest that long-term strenuous activity may increase the risk of cognitive impairment in recently postmenopausal women," Tierney said. "On the other hand, moderate long-term physical activity may improve later life cognition. These preliminary findings have important implications for women's health and support the need for large-scale studies including both women and men."

Alzheimer's Risk Gene May Reduce Benefits of Physical Activity to Cognitive Ability

While the relationship of physical activity with cognitive performance as we age is a subject of considerable research, much less is known about how this relationship is impacted by the Alzheimer's risk gene Apolipoprotein E (APOE). The APOE gene comes in three types, or alleles, known as e2, e3, and e4. Each person gets one type of APOE from each parent, making the possible combinations: e2/e2, e2/e3, e2/e4, e3/e3, e3/e4, e4/e4. Having two copies of e4 conveys the highest risk for Alzheimer's; having one e4 also raises one's risk. E3 is the most common type. E2, though rare, is thought to be protective.

Thomas Obisesan, MD, MPH, FAAFP, Chief of the Division of Geriatrics at Howard University Hospital and professor of medicine at Howard University College of Medicine, Washington, D.C., and colleagues examined this issue using data from The Third National Health and Nutrition Examination Survey (NHANES III, 1988-1994). They identified 1,799 men and women age 60 and older who had data on levels of aerobic-related physical activity (AR-PA), such as walking, jogging, bicycling or swimming; mental status test scores; and APOE genotype.

In their analysis, the researchers found that physical activity was associated with enhanced cognitive function, and that this relationship was differentially influenced by the person's APOE genotype: non-E4 carriers and people with one copy of E4 performed better than people with two copies of E4. After adjusting for
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Contact: Niles Frantz
niles.frantz@alz.org
312-363-8782
Alzheimer's Association
Source:Eurekalert

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