Navigation Links
A heart beats to a different drummer
Date:8/15/2010

Love, exercise and, new research shows, an infrared laser can make a heart beat faster.

Scientists at Case Western Reserve University and Vanderbilt University found that pulsed light can pace contractions in an avian embryonic heart, with no apparent damage to the tissue. The work, "Optical pacing of the embryonic heart," will be published in the advanced online issue of Nature Photonics on Aug. 15, 2010.

According to the scientists, this non-invasive device may prove an effective tool in understanding how environmental factors that alter an embryo's heart rate lead to congenital defects. It may also lead to investigations of cardiac electrophysiology at the cellular, tissue and organ levels, and possibly the development of a new generation of pacemakers.

"The mechanisms behind many congenital defects are not well known. But, there is a suspicion that when the early embryonic heart beats slower or faster than normal, that changes gene regulation and changes development," said Michael Jenkins, a postdoctoral researcher in biomedical engineering at Case Western Reserve.

"If we can precisely control pacing, we could figure out how structure, function and gene expression all work together," said Michiko Watanabe, PhD, professor of pediatrics, genetics and anatomy at Case Western Reserve School of Medicine.

Jenkins came up with the idea to try the infrared laser on an embryonic heart. He stumbled on an obscure paper from the 1960s in which researchers found that continuous exposure to visible light accelerated the heart rate of an embryonic chicken. He also knew of the success that Eric D. "Duco" Jansen, a professor of biomedical engineering at Vanderbilt University, had using an infrared laser to stimulate nerves. He then hypothesized that pulsed infrared light may enable pacing of the embryonic heart.

Case Western Reserve explained the proposed experiment to Jansen, who agreed to collaborate.

A video of the embryonic heart pacing, recorded by Jenkins, may be seen at: https://rcpt.yousendit.com/926316489/f2f087c288e36c9246bdd5dd95e145af

How does the laser make the heart beat?

The investigators believe a pulse of infrared light creates a temperature gradient in heart tissue that opens ion channels in a cascade along a heart cell. This effect spurs along an electrical impulse that makes the heart contract.

It's early in the research, "but we think this has exciting implications, especially if we can extend this into the adult heart," said Andrew Rollins, professor of biomedical engineering at Case Western Reserve.

Rollins' lab is now experimenting with adult heart tissue, to determine whether the laser could be used as an implantable pacemaker or to pace an adult heart during surgery or other clinical work.

Watanabe, who specializes in heart development and has studied heart conduction in the developing heart, said the findings could lead to the development of a pacemaker for a child's or baby's heart or even in utero. However, many more studies have to be done to show it would work and be safe. In a young heart, electrodes can cause damage and long term use of traditional pacemakers can lead to heart failure, she said.


'/>"/>

Contact: Kevin Mayhood
kevin.mayhoood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert

Related biology news :

1. Free statins with fast food could neutralize heart risk, scientists say
2. A strategy to fix a broken heart
3. Health care using telephone and telemonitoring technology benefits heart failure patients
4. From the heart: How cells divide to form different but related muscle groups
5. Preventing heart problems while keeping a cool head
6. U of T researchers find link between childhood physical abuse and heart disease
7. Protein important in diabetes may also play a key role in heart disease, other disorders
8. Improving clinical use of stem cells to repair heart damage
9. Maternal diet and genes interact to affect heart development
10. Virgin olive oil and a Mediterranean diet fight heart disease by changing how our genes function
11. No heart benefit from Omega-3 in women with type 1 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/15/2016)... Yissum Research Development Company of the ... the Hebrew University, announced today the formation of ... various human biological indicators. Neteera Technologies has completed its ... investors. ... electromagnetic emissions from sweat ducts, enables reliable and speedy ...
(Date:3/11/2016)... 11, 2016 http://www.apimages.com ) - --> ... is available at AP Images ( http://www.apimages.com ) - ... used to produce the new refugee identity cards. DERMALOG will be ... CeBIT in Hanover next week.   --> ... be used to produce the new refugee identity cards. DERMALOG will ...
(Date:3/10/2016)... , March 10, 2016   Unisys Corporation ... and Border Protection (CBP) is testing its biometric identity ... San Diego to help identify certain non-U.S. citizens ... . The test, designed to help determine the efficiency and ... began in February and will run until May 2016. ...
Breaking Biology News(10 mins):
(Date:5/27/2016)... ... May 27, 2016 , ... Weeks after hosting a carpal tunnel ... Michael Fitzmaurice, hand surgeon and founder of the Fitzmaurice Hand Institute, has announced the ... machine is a state-of-the-art technology and only 1 of about 3 currently available in ...
(Date:5/26/2016)... May 26, 2016  Agriculture nutrients are in the ... Iowa is running their nitrate removal system ... Erie and coastal regions nationwide are painting ... this widespread issue. NECi Superior Enzymes, a ... Peninsula, developed a new, easy to use device that ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... today announced several positive developments that position the Company for the future. ... the transaction, Craig F. Kinghorn has been appointed Chairman of the Board, Curtis ...
(Date:5/25/2016)... ... 2016 , ... Founder of the Fitzmaurice Hand Institute in ... of the hand by the National Board of Physicians and Surgeons, as of ... in his pursuit of providing the most comprehensive, effective treatment for his patients, ...
Breaking Biology Technology: