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A heart beats to a different drummer
Date:8/15/2010

Love, exercise and, new research shows, an infrared laser can make a heart beat faster.

Scientists at Case Western Reserve University and Vanderbilt University found that pulsed light can pace contractions in an avian embryonic heart, with no apparent damage to the tissue. The work, "Optical pacing of the embryonic heart," will be published in the advanced online issue of Nature Photonics on Aug. 15, 2010.

According to the scientists, this non-invasive device may prove an effective tool in understanding how environmental factors that alter an embryo's heart rate lead to congenital defects. It may also lead to investigations of cardiac electrophysiology at the cellular, tissue and organ levels, and possibly the development of a new generation of pacemakers.

"The mechanisms behind many congenital defects are not well known. But, there is a suspicion that when the early embryonic heart beats slower or faster than normal, that changes gene regulation and changes development," said Michael Jenkins, a postdoctoral researcher in biomedical engineering at Case Western Reserve.

"If we can precisely control pacing, we could figure out how structure, function and gene expression all work together," said Michiko Watanabe, PhD, professor of pediatrics, genetics and anatomy at Case Western Reserve School of Medicine.

Jenkins came up with the idea to try the infrared laser on an embryonic heart. He stumbled on an obscure paper from the 1960s in which researchers found that continuous exposure to visible light accelerated the heart rate of an embryonic chicken. He also knew of the success that Eric D. "Duco" Jansen, a professor of biomedical engineering at Vanderbilt University, had using an infrared laser to stimulate nerves. He then hypothesized that pulsed infrared light may enable pacing of the embryonic heart.

Case Western Reserve explained the proposed experiment to Jansen, who agreed to collaborate.


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Contact: Kevin Mayhood
kevin.mayhoood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert

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