Navigation Links
A heart beats to a different drummer
Date:8/15/2010

Love, exercise and, new research shows, an infrared laser can make a heart beat faster.

Scientists at Case Western Reserve University and Vanderbilt University found that pulsed light can pace contractions in an avian embryonic heart, with no apparent damage to the tissue. The work, "Optical pacing of the embryonic heart," will be published in the advanced online issue of Nature Photonics on Aug. 15, 2010.

According to the scientists, this non-invasive device may prove an effective tool in understanding how environmental factors that alter an embryo's heart rate lead to congenital defects. It may also lead to investigations of cardiac electrophysiology at the cellular, tissue and organ levels, and possibly the development of a new generation of pacemakers.

"The mechanisms behind many congenital defects are not well known. But, there is a suspicion that when the early embryonic heart beats slower or faster than normal, that changes gene regulation and changes development," said Michael Jenkins, a postdoctoral researcher in biomedical engineering at Case Western Reserve.

"If we can precisely control pacing, we could figure out how structure, function and gene expression all work together," said Michiko Watanabe, PhD, professor of pediatrics, genetics and anatomy at Case Western Reserve School of Medicine.

Jenkins came up with the idea to try the infrared laser on an embryonic heart. He stumbled on an obscure paper from the 1960s in which researchers found that continuous exposure to visible light accelerated the heart rate of an embryonic chicken. He also knew of the success that Eric D. "Duco" Jansen, a professor of biomedical engineering at Vanderbilt University, had using an infrared laser to stimulate nerves. He then hypothesized that pulsed infrared light may enable pacing of the embryonic heart.

Case Western Reserve explained the proposed experiment to Jansen, who agreed to collaborate.

A video of the embryonic heart pacing, recorded by Jenkins, may be seen at: https://rcpt.yousendit.com/926316489/f2f087c288e36c9246bdd5dd95e145af

How does the laser make the heart beat?

The investigators believe a pulse of infrared light creates a temperature gradient in heart tissue that opens ion channels in a cascade along a heart cell. This effect spurs along an electrical impulse that makes the heart contract.

It's early in the research, "but we think this has exciting implications, especially if we can extend this into the adult heart," said Andrew Rollins, professor of biomedical engineering at Case Western Reserve.

Rollins' lab is now experimenting with adult heart tissue, to determine whether the laser could be used as an implantable pacemaker or to pace an adult heart during surgery or other clinical work.

Watanabe, who specializes in heart development and has studied heart conduction in the developing heart, said the findings could lead to the development of a pacemaker for a child's or baby's heart or even in utero. However, many more studies have to be done to show it would work and be safe. In a young heart, electrodes can cause damage and long term use of traditional pacemakers can lead to heart failure, she said.


'/>"/>

Contact: Kevin Mayhood
kevin.mayhoood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert

Related biology news :

1. Free statins with fast food could neutralize heart risk, scientists say
2. A strategy to fix a broken heart
3. Health care using telephone and telemonitoring technology benefits heart failure patients
4. From the heart: How cells divide to form different but related muscle groups
5. Preventing heart problems while keeping a cool head
6. U of T researchers find link between childhood physical abuse and heart disease
7. Protein important in diabetes may also play a key role in heart disease, other disorders
8. Improving clinical use of stem cells to repair heart damage
9. Maternal diet and genes interact to affect heart development
10. Virgin olive oil and a Mediterranean diet fight heart disease by changing how our genes function
11. No heart benefit from Omega-3 in women with type 1 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... , June 22, 2016   Acuant ... and verification solutions, has partnered with RightCrowd ... solutions for Visitor Management, Self-Service Kiosks and ... products that add functional enhancements to existing ... corporations and venues with an automated ID ...
(Date:6/15/2016)... 15, 2016 Transparency Market ... Recognition Market by Application Market - Global Industry Analysis Size ... to the report, the  global gesture recognition market ... and is estimated to grow at a CAGR ... 2024.  Increasing application of gesture recognition ...
(Date:6/2/2016)... , June 2, 2016 The ... has awarded the 44 million US Dollar project, for ... Embossed Vehicle Plates including Personalization, Enrolment, and IT Infrastructure ... leader in the production and implementation of Identity Management Solutions. ... January, however Decatur was selected for ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , ... June 23, 2016 , ... ... YM (Yeast and Mold) microbial test has received AOAC Research Institute approval 061601. ... microbial tests introduced last year,” stated Bob Salter, Vice President of Regulatory and ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the Industry ... Supplyframe Design Lab . Located in Pasadena, Calif., the Design Lab’s mission ... hardware projects are designed, built and brought to market. , The Design Lab ...
(Date:6/23/2016)... Calif. , June 23, 2016  Blueprint Bio, ... biological discoveries to the medical community, has closed its ... Matthew Nunez . "We have received ... with the capital we need to meet our current ... essentially provide us the runway to complete validation on ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... and technical consulting, provides a free webinar on Performing Quality Investigations: ... 2016 at 12pm CT at no charge. , Incomplete investigations are still a ...
Breaking Biology Technology: