Navigation Links
A golden bullet for cancer
Date:3/12/2010

In a lecture he delivered in 1906, the German physician Paul Ehrlich coined the term Zuberkugel, or "magic bullet," as shorthand for a highly targeted medical treatment.

Magic bullets, also called silver bullets, because of the folkloric belief that only silver bullets can kill supernatural creatures, remain the goal of drug development efforts today.

A team of scientists at Washington University in St. Louis is currently working on a magic bullet for cancer, a disease whose treatments are notoriously indiscriminate and nonspecific. But their bullets are gold rather than silver. Literally.

The gold bullets are gold nanocages that, when injected, selectively accumulate in tumors. When the tumors are later bathed in laser light, the surrounding tissue is barely warmed, but the nanocages convert light to heat, killing the malignant cells.

In an article just published in the journal Small, the team describes the successful photothermal treatment of tumors in mice.

The team includes Younan Xia, Ph.D., the James M. McKelvey Professor of Biomedical Engineering in the School of Engineering and Applied Science, Michael J. Welch, Ph.D., professor of radiology and developmental biology in the School of Medicine, Jingyi Chen, Ph.D., research assistant professor of biomedical engineering and Charles Glaus, Ph.D., a postdoctoral research associate in the Department of Radiology.

"We saw significant changes in tumor metabolism and histology," says Welch, "which is remarkable given that the work was exploratory, the laser 'dose' had not been maximized, and the tumors were 'passively' rather than 'actively' targeted."

Why the nanocages get hot

The nanocages themselves are harmless. "Gold salts and gold colloids have been used to treat arthritis for more than 100 years," says Welch. "People know what gold does in the body and it's inert, so we hope this is going to be a nontoxic approach."


'/>"/>
Contact: Diana Lutz
dlutz@wustl.edu
314-935-5272
Washington University in St. Louis
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. What should goldenrod do to avoid an insect attack? Duck
2. Like little golden assassins, smart nanoparticles identify, target and kill cancer cells
3. Mystery of golden ratio explained
4. A new gene silencing platform -- silence is golden
5. Computation and genomics data drive bacterial research into new golden age
6. PET/CT imaging proves golden for detecting cancer in children
7. New golden frog discovered in remote region of Colombia
8. Researchers reveal 3-D structure of bullet-shaped virus with potential to fight cancer, HIV
9. New advance in revolutionary bullet fingerprinting technique
10. LSTM and UoL secure £1.4m ($2m) to develop new magic bullet antimalarial drug
11. January-February GSA Bulletin media highlights
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A golden bullet for cancer
(Date:12/10/2014)... You,ve been here before: you desperately need to ... password, site key or the answer to your secret question. ... Today, Hoyos Labs , a digital ... finally put an end to the frustration that comes with ... 1U leverages a user,s smartphone to acquire his or her ...
(Date:12/10/2014)... 2014     ...   Jifflenow, a leading ... for business-to-business (B2B) events, today announced a partnership ... near-field communication (NFC), Bluetooth low energy (BLE), and ... , Jifflenow will integrate its meeting ...
(Date:12/3/2014)... , Dec. 2, 2014 As part of ... Inception Technologies is pleased to announce the release of ... customers to collect the workforce data that they need. ... have been left by existing readers. Many such devices ... connectivity and modern technology. Older models force users to ...
Breaking Biology News(10 mins):The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3Inception Technologies to Release New Biometric Reader 2
... of Canada - with assistance from the U.S. Army ... vaccines against the Ebola and Marburg viruses that have ... In a study published in this month's Nature Medicine, ... of PHAC's National Microbiology Laboratory and Dr. Thomas Geisbert ...
... chemical signals that attracts developing sensory nerves up the ... nerves, sending them in the opposite direction, down the ... the University of Chicago in the September 2005 issue ... may help physicians restore function to people with paralyzing ...
... with strands of DNA can create tiny sensors with ... at the University of Pennsylvania and Monell Chemical Sciences ... of the journal Nano Letters, a publication of the ... of these nanosensors could detect molecules on the order ...
Cached Biology News:Researchers report breakthrough against world’s deadliest viruses 2Gradient guides nerve growth down spinal cord 2Gradient guides nerve growth down spinal cord 3Researchers Create DNA-Based Sensors for Nano-Tongues and Nano-Noses 2
(Date:12/24/2014)... December 23, 2014 PharmaBoardroom,s ... out today and available for free download , digs ... change and growth in the sector today. One ... successes has been in developing a homegrown pharmaceutical manufacturing base, ... production still remains some way off. A cursory comparison with ...
(Date:12/22/2014)... 2014 The Center for Professional ... technical training across the life sciences industry, has partnered ... (SCDM) to provide the organization's members with discounted classroom ... to the more than 350 sessions across 80 course ... off when registering for a public course ...
(Date:12/22/2014)... 22, 2014 GenomeDx Biosciences today announced that ... Classifier, a genomic test for prostate cancer, was able ... managed by radical prostatectomy without adjuvant therapy. Although rapid ... uncommon, using tumor genomics to identify these men who ... an important advance. The study has been published ...
(Date:12/22/2014)... TENN (PRWEB) December 22, 2014 Fertility ... Donor Egg Bank USA , a network of ... country. Through this partnership, patients have fast access to ... in vitro fertilization, IVF . Fertility Associates of Memphis ... offer this fertility treatment option. , Dr. William ...
Breaking Biology Technology:PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3
... U.S. Naval Academy satellite called MidSTAR-1 have proven successful ... sensor that can check for harmful chemicals and the ... , These technologies were collaboratively developed between NASAs Goddard ... Moffett Field, Calif.; and Eclipse Energy Systems Inc. of ...
... Chemists at the National Institute of Standards and ... significant amounts of copper incorporated into zinc oxide ... because copper plays a significantbut not well-understoodrole in ... Previous experiments found only trace amounts of copper. ...
... Nash Corporation,(Nasdaq: KNSY ) is scheduled to ... the Mission Bay Conference Center in San,Francisco on ... Kensey Nash,s Chief Operating Officer, will deliver,the Company,s ... materials will be available on the company,s website,( ...
Cached Biology Technology:NASA MidSTAR-1 successful technologies may be revolutionary 2NASA MidSTAR-1 successful technologies may be revolutionary 3NASA MidSTAR-1 successful technologies may be revolutionary 4Chemists measure copper levels in zinc oxide nanowires 2
G-Protein Coupled Receptor Assay, For 500 assays. SPA. Category: Drug Screening & Cellular Assays, Assays ....
... Panomer 9 oligodeoxynucleotides ... are labeled at the ... proprietary Alexa Fluor dyes ... for assessing microarray spot ...
EDTA, disodium salt, 1 kg. Ethylene diaminetetraacetic acid.Dihydrate. Assay: 99.0-101.0%, nuclease-free.Risks: 36, 37, 38 ; Safety Precautions: 22, 36, 37. Category: Nucleotides & Enzymes & Biochemi...
Mycoplasma tested...
Biology Products: