Navigation Links
A global breakthrough in the study of a protein linked to the spread of viruses
Date:1/5/2010

nopartite NLS, i.e. an NLS comprising one continuous sequence of amino acids. Much to their surprise, Denis Archambault and Andrea Gomez Corredor discovered that the BIV Rev protein has a bipartite NLS composed of two amino acid motifs separated by a sequence of additional amino acids a world first for this type of protein in all retroviruses studied to date, including the AIDS virus.

In addition, although other types of protein contain a bipartite NLS, this newly discovered NLS does not match any other bipartite NLS identified until now, whatever the type of protein studied. Normally a bipartite NLS is composed of two amino acid motifs separated by a spacer sequence, which is either short (about 10 amino acids) or long (about 30 amino acids). In the BIV Rev protein, the NLS is atypical because of the length of the spacer sequence (neither long nor short) and the amino acid composition of that sequence.

Finally, the authors also identified a new type of nucleolar localization signal (NoLS) which allows the Rev protein to penetrate inside the nucleoli. Although the role of this localization is unknown, it is the first time this type of signal has been reported in proteins of cellular or viral origin.

A first step toward further discoveries

According to Denis Archambault, "What we have here is a Rev protein whose characteristics are very different from the other proteins of the same type that have been studied to date. Although our findings relate to basic research, our study demonstrates that it is possible to learn a lot about viruses, and in particular a virus of animal origin. We now have a specific model that will allow us to study further the relationship between the localization of a protein and its effect on the host cell, and possibly the entire organism."


'/>"/>

Contact: Claire Bouchard
bouchard.claire@uqam.ca
514-987-3111
Universit du Qubec Montral
Source:Eurekalert

Page: 1 2

Related biology news :

1. Global Warming and the Habitability of Planet Earth, Sept. 26
2. Green skies: Engineers work may reduce jet travels role in global warming
3. Scientists in first global study of poison gas in the atmosphere
4. North Americas northernmost lake affected by global warming
5. IEEE-USA innovation forum will help prepare US tech leaders to prosper in a global marketplace
6. Majority of Americans want local action on global warming, says poll
7. International team of scientists warns of climate changes impact on global river flow
8. Changing the global dietary environment
9. Global deal fuels QUTs world-changing research
10. NIH hosts event to launch Council of Science Editors global theme issue
11. Agricultural soil erosion is not adding to global warming
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... NXTD and NXTDW) a biometric authentication company focused on ... Wocket™ smart wallet at CES 2015 in Las Vegas ... the "11 Hot Products at CES" in a review published in Wired.com, ... Newseveryday.com and "The top 10 gadgets from CES 2015" by Danny ...
(Date:1/22/2015)... 2015  Analyst Report Issued by Small Cap IR. In 2011, ... planet-wide, transactions at merchants on the leading payment cards rose ... credit, debit, and prepaid cards reached 6.54 billion.  Eight million ... card usage in 2012, and credit and debit card fraud ...
(Date:1/22/2015)... DUBLIN , Jan. 22, 2015 Research and ... the addition of the "Global Wearable Technologies ... Growth, Share, Overview, Trends and Forecast 2014-2020" ... Wearable Technologies are smart devices that can be ...
Breaking Biology News(10 mins):CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2
... Norway have deduced how bony fishes conquered the oceans ... with the water of life ?the degradation of yolk ... eggs to fill with vital water and float. This ... that showed an unprecedented radiation during the late Cretaceous ...
... million people died during a worldwide influenza pandemic caused ... virus. Recently H5N1, another highly infectious avian strain has ... is great concern that this virus might also mutate ... Specific mutations in a viral protein, the polymerase, contribute ...
... risk of HIV infection among women with a common ... in the past to show the link between sexually ... in the March 1 issue of The Journal of ... first to demonstrate a statistically significant association between trichomoniasis ...
Cached Biology News:How fish conquered the ocean 2How fish conquered the ocean 3A first glimpse of the influenza replication machine 2Common parasitic infection leads to increased risk for HIV infection 2
(Date:1/22/2015)... , 22 de enero de 2015  El Dr. ... su llamada a nominaciones para 2015. Este prestigioso premio ... o tiene el potencial para hacer, contribuciones destacadas para ... aceptarán hasta el 15 de marzo de 2015 a ...
(Date:12/25/2014)... 2014 The report “Service Quality Management ... & Provider Type - Global Advancements, Worldwide Forecasts & ... in-depth analysis and forecasting of revenues. , Browse ... pages and in-depth TOC on “Service Quality Management (SQM) ...
(Date:12/24/2014)... “Preparative & Process Chromatography Market ... (Columns, Solvents, Buffers, Valves, Guages, Seals), Accessories, Services, ... Forecasts to 2019” provides a detailed overview of ... trends, and strategies impacting the preparative and process ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 According to Ross ... Island Affiliate of ITRA Global, the national office market continues ... recovery. This is evidenced by the third quarter’s surprising ... market. Low energy costs have held inflation down and ...
Breaking Biology Technology:El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3
... Mass., March 19 Biopure,Corporation (Nasdaq: ... Kingdom,s,Medicines and Healthcare products Regulatory Agency (MHRA) ... manufacturing facility. The,inspection report contained no "Critical" ... manufacturing practices. The MHRA report identified,shortcomings characterized ...
... 19 AdvanDx announced it received,Frost & ... Award in the,field of rapid in-vitro molecular ... on AdvanDx,s easy-to-use, molecular-based,PNA FISH(TM) diagnostics to ... days. The rapid PNA FISH results enable ...
... MacroChem,Corporation (OTC Bulletin Board: MACM) today announced ... of Chief Financial Officer, effective,immediately. Mr. Luci has ... Development since joining the Company in December,2007., ... Inc. prior to its,successful merger transaction with Genzyme ...
Cached Biology Technology:Biopure Completes U.K. Regulatory Agency Inspection 2AdvanDx Receives Frost & Sullivan's Rapid In-Vitro Diagnostic Technology Innovation of the Year Award 2AdvanDx Receives Frost & Sullivan's Rapid In-Vitro Diagnostic Technology Innovation of the Year Award 3AdvanDx Receives Frost & Sullivan's Rapid In-Vitro Diagnostic Technology Innovation of the Year Award 4MacroChem Appoints David P. Luci as New CFO 2MacroChem Appoints David P. Luci as New CFO 3