Navigation Links
A genetic basis for schizophrenia
Date:7/21/2009

Chicago, Illinois, July 21, 2009 Schizophrenia is a severely debilitating psychiatric disease that is thought to have its roots in the development of the nervous system; however, major breakthroughs linking its genetics to diagnosis, prognosis and treatment are still unrealized. Jill Morris, PhD assistant professor of Pediatrics at Northwestern University's Feinberg School of Medicine and a researcher in the Human Molecular Genetics Program of Children's Memorial Research Center studies a gene that is involved in susceptibility to schizophrenia, Disc1 (Disrupted-In-Schizophrenia 1). Two recent publications by Morris and colleagues focus on the role of Disc1 in development, particularly the migration of cells to their proper location in the brain and subsequent differentiation into their intended fate. During development, cells need to properly migrate to their final destination in order to develop into the appropriate cell-type, integrate into the corresponding network of cells and function properly. Disruption of cell migration can lead to inappropriate cell development and function, resulting in disease.

The first paper, published in the July 2009 online issue of the journal Development, followed the role of Disc1 in cranial neural crest (CNC) cells, which are multi-potent cells that give rise to multiple cell types including craniofacial cartilage and the peripheral nervous system during development. They also are similar to neurons in their high mobility, response to signals and cellular origin. The Morris laboratory determined that Disc1 regulates two stem cell maintenance factors that have many functions in CNC cells, including the maintenance of precursor pools, timing of migration onset and the induction of cell differentiation. The authors showed that Disc1 disruption results in increased expression of these factors, leading to hindered cell migration and a change in cell fate. "This research indicates that Disc1 may be involved in re
'/>"/>

Contact: Peggy Jones
pmjones@childrensmemorial.org
773-755-6341
Children's Memorial Hospital
Source:Eurekalert

Page: 1 2

Related biology news :

1. Does the desire to consume alcohol and tobacco come from our genetic makeup?
2. Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
3. Many parents at-risk for cancer disclose genetic test results to children
4. Genetics determine optimal drug dose of common anticoagulant
5. Claims of sex-related differences in genetic association studies often not properly validated
6. American College of Medical Genetics responds to new FDA labeling decision for warfarin
7. UNC study questions FDA genetic-screening guidelines for cancer drug
8. Genome study shines light on genetic link to height
9. Selexis Announces Advanced Approach to Maximize Power of Genetic Elements for Rapid Development of High Performance Cell Lines
10. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
11. Rutgers Genetics receives $7.8 million for autism research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/17/2015)... JOSE, Calif. , June 17, 2015 /PRNewswire/ ... in human interface solutions, today announced that Xiaomi, ... adopted the Synaptics ® ClearPad ® ... of display driver integrated circuits (DDICs) for its ... Pro. By leveraging ClearPad for full in-cell display ...
(Date:6/16/2015)... /CNW Telbec/ - handyem Inc. and FlowMetric Diagnostics ... of handyem,s HPC-150 portable flow cytometer within FlowMetric ... unprecedented model of mobile laboratory platform is presented ... Pennsylvania Convention Center, ... to 18 th 2015.  By virtue of ...
(Date:6/16/2015)... 16, 2015 Fingerprint Cards has received ... in the company,s portfolio from one of its module partners ... mainly take place during the third quarter 2015. The sensors ... . Jörgen Lantto, CEO of FPC, comments: ...   growing interest from smartphone OEMs in integrating touch fingerprint ...
Breaking Biology News(10 mins):Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 2Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 3handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 2handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 3FPC Receives Order for Touch Fingerprint Sensors of 375 MSEK 2
... meeting in London this week for a three-day "summit" ... meeting which includes experts from academia, industry and ... will discuss the latest research on bee health, identify ... , The meeting (22-24 January 2014), organised by ...
... of fire keeps researchers returning to the lab to ... powered our world and consumed scientific attention for years, ... the focus with the Burning and Suppression of Solids-II ... Station aboard the Orbital 1 cargo resupply mission. ...
... 20 January 2014 Scientists from the Montreal ... that two genes linked to hereditary Parkinson,s disease ... mitochondria. The protective mechanism, which is reported in ... that arise from oxidative stress from mitochondria., "PINK1 ...
Cached Biology News:Combustion continues to draw researchers to space station 2Combustion continues to draw researchers to space station 3Quality control of mitochondria as a defense against disease 2
(Date:7/3/2015)... ... July 03, 2015 , ... ... applications such as animal waste reduction, bioremediation, wastewater treatment, aquaculture and grease, ... announced today that it will be showcasing, ManureMagic™, its industry-leading product for ...
(Date:7/3/2015)... , July 3, 2015 /PRNewswire/ ... hakea verkossa osoitteessa  http://www.openinnovationinscience.at ... Innovation in Science" -jatkokoulutusohjelmaan 22.7.2015 ... Gesellschaftin (LBG) tekemän, kansainvälisiä tutkijoita ... terveystieteiden kaksi suurinta haastetta ovat ...
(Date:7/3/2015)... ... July 03, 2015 , ... The ... companies and professional service industries alike-- typically known for its consummate professionalism-- embarks ... a good cause and break from their day jobs. , "Our motto has ...
(Date:7/3/2015)... ... July 03, 2015 , ... The global failure analysis ... from 2015 to 2020. The bioscience market is expected to grow at the highest ... of failure analysis equipment in the research labs and academic institutions for root cause ...
Breaking Biology Technology:DryLet to Highlight Benefits of Patented ManureMagic™ at North American Manure Expo in Chambersburg, PA July 14-15, 2015 2Maailman ensimmäinen tiedemiesten koulutukseen suunniteltu avoimen innovaation ohjelma käynnistyy 2Maailman ensimmäinen tiedemiesten koulutukseen suunniteltu avoimen innovaation ohjelma käynnistyy 3The Alexander Group Declares Their Independence with a Bit of Levity 2Failure Analysis Market to Grow at 7.52% CAGR to 2020 2Failure Analysis Market to Grow at 7.52% CAGR to 2020 3Failure Analysis Market to Grow at 7.52% CAGR to 2020 4Failure Analysis Market to Grow at 7.52% CAGR to 2020 5
... 15,000 of them. A Northwestern University research team ... with tiny beams of light using an innovative nanofabrication ... new method, which could do for nanofabrication what the ... will be published Aug. 1 by the journal ...
... , BRUSSELS , July 30  The ... and processing approvals for biotechnology maize products jointly developed by ... business Pioneer Hi-Bred and Dow AgroSciences LLC ... Company . Maize products containing the Herculex® I insect protection ...
... carbon that consists of a single layer of carbon ... experimental surprises. In the current issue of the journal ... by Michael Crommie, a faculty senior scientist in the ... Lawrence Berkeley National Laboratory and a professor of physics ...
Cached Biology Technology:15,000 beams of light 215,000 beams of light 3European Union Approves Maize with Herculex® I/Herculex® RW and Herculex® RW/ Herculex® I/Roundup Ready® Corn 2 Trait Stacks for Import, Food, Feed & Processing 2European Union Approves Maize with Herculex® I/Herculex® RW and Herculex® RW/ Herculex® I/Roundup Ready® Corn 2 Trait Stacks for Import, Food, Feed & Processing 3European Union Approves Maize with Herculex® I/Herculex® RW and Herculex® RW/ Herculex® I/Roundup Ready® Corn 2 Trait Stacks for Import, Food, Feed & Processing 4Graphene under strain creates gigantic pseudo-magnetic fields 2Graphene under strain creates gigantic pseudo-magnetic fields 3Graphene under strain creates gigantic pseudo-magnetic fields 4
... G Dye runs faster than Bromophenol ... agarose gels.,Orange G dye migrates with ... The migration at this size,prevents the ... indicates the front of DNA migration.,The ...
... Description: 100 ... Detects 70 kDa YAP from Human/mouse/rat ... immunohistochemistry. Research ... Storage: -20C ...
Rabbit polyclonal to QKI...
Mouse polyclonal antibody to QPRT - quinolinate phosphoribosyltransferase (nicotinate-nucleotide pyrophosphorylase (carboxylating))...
Biology Products: