Navigation Links
A genetic basis for schizophrenia
Date:7/21/2009

Chicago, Illinois, July 21, 2009 Schizophrenia is a severely debilitating psychiatric disease that is thought to have its roots in the development of the nervous system; however, major breakthroughs linking its genetics to diagnosis, prognosis and treatment are still unrealized. Jill Morris, PhD assistant professor of Pediatrics at Northwestern University's Feinberg School of Medicine and a researcher in the Human Molecular Genetics Program of Children's Memorial Research Center studies a gene that is involved in susceptibility to schizophrenia, Disc1 (Disrupted-In-Schizophrenia 1). Two recent publications by Morris and colleagues focus on the role of Disc1 in development, particularly the migration of cells to their proper location in the brain and subsequent differentiation into their intended fate. During development, cells need to properly migrate to their final destination in order to develop into the appropriate cell-type, integrate into the corresponding network of cells and function properly. Disruption of cell migration can lead to inappropriate cell development and function, resulting in disease.

The first paper, published in the July 2009 online issue of the journal Development, followed the role of Disc1 in cranial neural crest (CNC) cells, which are multi-potent cells that give rise to multiple cell types including craniofacial cartilage and the peripheral nervous system during development. They also are similar to neurons in their high mobility, response to signals and cellular origin. The Morris laboratory determined that Disc1 regulates two stem cell maintenance factors that have many functions in CNC cells, including the maintenance of precursor pools, timing of migration onset and the induction of cell differentiation. The authors showed that Disc1 disruption results in increased expression of these factors, leading to hindered cell migration and a change in cell fate. "This research indicates that Disc1 may be involved in regulating stem cells and their fate," says Morris.

The second paper, published in the June 2009 online issue of Human Molecular Genetics, studied the hippocampus, a brain area that is involved in learning and memory, and is also associated with the pathology of schizophrenia. Disc1 is highly expressed in the hippocampus, particularly the dentate gyrus, which is considered the gateway to the hippocampus. In this study, the authors decreased Disc1 expression using RNA interference in the developing mouse hippocampus. The loss of Disc1 resulted in hindered migration of dentate gyrus granule cells to their proper location in the brain. "Improper migration of hippocampal neurons may result in altered connectivity in the brain," says Morris.


'/>"/>

Contact: Peggy Jones
pmjones@childrensmemorial.org
773-755-6341
Children's Memorial Hospital
Source:Eurekalert

Related biology news :

1. Does the desire to consume alcohol and tobacco come from our genetic makeup?
2. Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
3. Many parents at-risk for cancer disclose genetic test results to children
4. Genetics determine optimal drug dose of common anticoagulant
5. Claims of sex-related differences in genetic association studies often not properly validated
6. American College of Medical Genetics responds to new FDA labeling decision for warfarin
7. UNC study questions FDA genetic-screening guidelines for cancer drug
8. Genome study shines light on genetic link to height
9. Selexis Announces Advanced Approach to Maximize Power of Genetic Elements for Rapid Development of High Performance Cell Lines
10. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
11. Rutgers Genetics receives $7.8 million for autism research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/4/2017)... , Oct. 4, 2017  GCE Solutions, a global clinical ... data and document anonymization solution on October 4, 2017. Shadow is ... field to comply with policy 0070 of the European Medicines Agency ... data. ... GCE Solutions ...
(Date:8/15/2017)... 15 2017   ivWatch LLC , a medical device company ... today announced receipt of its ISO 13485 Certification, the global standard ... Organization for Standardization (ISO®). ... Model 400 Continuous Monitoring device for the early detection of IV ... "This is an important milestone for ...
(Date:6/30/2017)... 2017 Today, American Trucking Associations announced ... face and eye tracking software, became the newest ... "Artificial intelligence and advanced sensing ... a driver,s attentiveness levels while on the road.  ... detect fatigue and prevent potential accidents, which could ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... A new study published in ... and fresh in vitro fertilization (IVF) transfer cycles. The multi-center matched ... , After comparing the results from the fresh and frozen transfer cohorts, the ...
(Date:10/10/2017)... ... ... San Diego-based team building and cooking events company, Lajollacooks4u, has unveiled a ... new look is part of a transformation to increase awareness, appeal to new markets ... It will also expand its service offering from its signature gourmet cooking classes and ...
(Date:10/10/2017)... , ... October 10, 2017 , ... ... Center’s FirstHand program has won a US2020 STEM Mentoring Award. Representatives of the ... for Excellence in Volunteer Experience from US2020. , US2020’s mission is to change ...
(Date:10/10/2017)... International research firm Parks Associates announced today that ... TMA 2017 Annual Meeting , October 11 in Scottsdale, ... security market and how smart safety and security products impact the competitive ... Parks Associates: Smart Home Devices: Main ... "The residential security market has experienced continued ...
Breaking Biology Technology: