Navigation Links
A gene for metastasis
Date:8/27/2007

Colorectal cancer is one of the most prevalent cancers in the Western world. The tumor starts off as a polyp but then turns into an invasive and violent cancer, which often spreads to the liver. In an article recently published in the journal Cancer Research, Prof. Avri Ben-Zeev and Dr. Nancy Gavert of the Weizmann Institutes Molecular Cell Biology Department reveal mechanisms that help this cancer metastasize.

In a majority of cases, colorectal cancer is initiated by changes in a key protein beta-catenin. One of the roles of this protein is to enter the cell nucleus and activate gene expression. But in colorectal and other cancers, beta-catenin over-accumulates in the cell and inappropriately activates genes, leading to cancer.

Surprisingly, one of the genes activated by beta-catenin, which had been previously detected in colorectal cancer cells by Ben-Zeevs group, codes for a receptor called L1-CAM. This receptor is a protein usually found on nerve cells, where it plays a role in nerve cell recognition and motility. What is this receptor doing in cancer cells" Ben-Zeevs previous research had shown that L1-CAM is only expressed on certain cells located at the invasive front of the tumor tissue, hinting that it could be an important player in metastasis.

In this study, the scientists found that colorectal cancer cells engineered to express the L1-CAM gene indeed spread to the liver, while those cells lacking L1-CAM did not.

In collaboration with Prof. Eytan Domany and research student Michal Sheffer of the Insitutes Physics of Complex Systems Department, Ben-Zeev then compared the expression of genes induced by L1-CAM in cultured colon cancer cells to those in 170 samples of colorectal cancer tissue removed from patients, and in 40 samples of normal colon tissue. Out of some 160 genes induced by L1-CAM, about 60 were highly expressed in the cancerous tissue, but not in normal colon tissue. Ben-Zeev plans to conduct further research into the role of these genes, to uncover L1-CAMs function in metastasis.


'/>"/>

Contact: Yivsam Azgad
news@weizmann.ac.il
972-893-43856
Weizmann Institute of Science
Source:Eurekalert

Related biology news :

1. 3-D model reveals secrets of metastasis
2. Two-faced protein can stop metastasis or promote it, researchers say
3. Newly discovered behavior in cancer cells signals dangerous metastasis
4. Trojan Horse agent halts bone metastasis in mice
5. Inflammation may play role in metastasis of prostate cancer
6. Genes set scene for metastasis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... , April 5, 2017 Today ... announcing that the server component of the HYPR platform ... for providing the end-to-end security architecture that empowers biometric ... HYPR has already secured over 15 million users ... including manufacturers of connected home product suites and physical ...
(Date:3/30/2017)... 2017  On April 6-7, 2017, Sequencing.com will host ... hackathon at Microsoft,s headquarters in Redmond, ... on developing health and wellness apps that provide a ... Genome is the first hackathon for personal genomics ... companies in the genomics, tech and health industries are ...
(Date:3/28/2017)... The report "Video Surveillance Market ... Storage Devices), Software (Video Analytics, VMS), and Service (VSaaS, ... to 2022", published by MarketsandMarkets, the market was valued ... to reach USD 75.64 Billion by 2022, at a ... year considered for the study is 2016 and the ...
Breaking Biology News(10 mins):
(Date:5/18/2017)... , ... May 18, 2017 , ... ... The Tapas Cooking Challenge is a two-hour team-building package designed for groups ... created by Chef Jodi Abel, which include items, such as Blackened Shrimp with ...
(Date:5/18/2017)... (PRWEB) , ... May 17, 2017 , ... ... specializing in medical device compliance and commercialization, has just released version 9.0 of ... work into this latest version of Cockpit,” says David Cronin, CEO of Cognition. ...
(Date:5/18/2017)... , ... May 17, 2017 , ... ... for example, are more likely to develop Alzheimer’s disease, while men are at ... account for this gender-specific neuronal bias is the aim of a research program ...
(Date:5/16/2017)... ... 16, 2017 , ... Zansors has secured a patent ... or EKG) acquisition and monitoring device. This Zansors’ next-generation intellectual property (IP), will ... the skin, making them significantly easier to deploy and use. , Currently, ECG ...
Breaking Biology Technology: