Navigation Links
A gene for metastasis
Date:8/27/2007

Colorectal cancer is one of the most prevalent cancers in the Western world. The tumor starts off as a polyp but then turns into an invasive and violent cancer, which often spreads to the liver. In an article recently published in the journal Cancer Research, Prof. Avri Ben-Zeev and Dr. Nancy Gavert of the Weizmann Institutes Molecular Cell Biology Department reveal mechanisms that help this cancer metastasize.

In a majority of cases, colorectal cancer is initiated by changes in a key protein beta-catenin. One of the roles of this protein is to enter the cell nucleus and activate gene expression. But in colorectal and other cancers, beta-catenin over-accumulates in the cell and inappropriately activates genes, leading to cancer.

Surprisingly, one of the genes activated by beta-catenin, which had been previously detected in colorectal cancer cells by Ben-Zeevs group, codes for a receptor called L1-CAM. This receptor is a protein usually found on nerve cells, where it plays a role in nerve cell recognition and motility. What is this receptor doing in cancer cells" Ben-Zeevs previous research had shown that L1-CAM is only expressed on certain cells located at the invasive front of the tumor tissue, hinting that it could be an important player in metastasis.

In this study, the scientists found that colorectal cancer cells engineered to express the L1-CAM gene indeed spread to the liver, while those cells lacking L1-CAM did not.

In collaboration with Prof. Eytan Domany and research student Michal Sheffer of the Insitutes Physics of Complex Systems Department, Ben-Zeev then compared the expression of genes induced by L1-CAM in cultured colon cancer cells to those in 170 samples of colorectal cancer tissue removed from patients, and in 40 samples of normal colon tissue. Out of some 160 genes induced by L1-CAM, about 60 were highly expressed in the cancerous tissue, but not in normal colon tissue. Ben-Zeev plans to conduct further research into the role of these genes, to uncover L1-CAMs function in metastasis.


'/>"/>

Contact: Yivsam Azgad
news@weizmann.ac.il
972-893-43856
Weizmann Institute of Science
Source:Eurekalert

Related biology news :

1. 3-D model reveals secrets of metastasis
2. Two-faced protein can stop metastasis or promote it, researchers say
3. Newly discovered behavior in cancer cells signals dangerous metastasis
4. Trojan Horse agent halts bone metastasis in mice
5. Inflammation may play role in metastasis of prostate cancer
6. Genes set scene for metastasis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... DUBLIN , Apr. 11, 2017 Research ... Tracking Market 2017-2021" report to their offering. ... The global eye tracking market to grow at ... The report, Global Eye Tracking Market 2017-2021, has been prepared based ... report covers the market landscape and its growth prospects over the ...
(Date:4/5/2017)... -- Today HYPR Corp. , leading innovator in ... the HYPR platform is officially FIDO® Certified . ... that empowers biometric authentication across Fortune 500 enterprises and ... 15 million users across the financial services industry, however ... suites and physical access represent a growing portion of ...
(Date:3/30/2017)... KONG , March 30, 2017 The ... a system for three-dimensional (3D) fingerprint identification by adopting ground breaking ... into a new realm of speed and accuracy for use in ... at an affordable cost. ... ...
Breaking Biology News(10 mins):
(Date:6/26/2017)... ... 2017 , ... Third Wave Bioactives, LLC announces the addition of Brett Thompson. ... business development and ensuring quality customer experience. , Brett brings to Third ... technical, marketing and sales roles. “Brett’s background working with customers and eye for market ...
(Date:6/23/2017)... CARDIFF, UK (PRWEB) , ... June 23, 2017 , ... ... Brian Lula, president of Physik Instrumente USA, have been selected as this year’s recipients ... . , The two have been invited along with other honorees to accept their ...
(Date:6/22/2017)... ... 2017 , ... Building on the success of the inaugural RAADfest last year, ... latest developments in radical life extension. RAADfest combines cutting edge science presented for a ... personal development, making it the largest most comprehensive and inclusive super longevity event in ...
(Date:6/22/2017)... ... 22, 2017 , ... The first human cell line HeLa, established in 1951, ... on cross-contamination of human cell lines with HeLa cells were published. Until recently, cross-contamination ... labs and is associated with dramatic consequences for research. , In this educational ...
Breaking Biology Technology: