Navigation Links
A gene family that suppresses prostate cancer
Date:3/13/2014

re signs of precancerous lesions early in development, but no cancer by 15 months of age. When miR-34 and p53 genes were both silenced together, the researchers observed full prostate cancer in the mice.

The findings revealed that "miR-34 can be a tumor-suppressor gene, but it has to work together with p53," Nikitin said.

In mice that had both miR-34 and p53 silenced concurrently, cancerous lesions formed in a proximal part of the prostrate ducts, in a compartment known to contain prostate stem cells. The early lesions that developed when p53 was silenced alone occurred in a distal part of the ducts, away from the compartment where the stem cell pool is located. This suggested there was another mechanism involved when p53 and miR-34 were jointly silenced.

Also, the number of stem cells in mice with both p53 and miR-34 silenced increased substantially compared with control mice or mice with only miR-34 or p53 independently silenced.

"These results indicated that together miR-34 and p53 regulate the prostate stem cell compartments," said Nikitin.

This is significant, as cancer frequently develops when stem cells become unregulated and grow uncontrollably, he said.

Researchers further found that p53 and miR-34 affect stem cell growth by regulating MET expression. In absence of p53 and miR-34, MET is overexpressed, which leads to uncontrolled growth of prostate stem cells and high levels of cancer in these mice.

Future work will further examine the role of p53/miR-34/MET genes in stem cell growth and cancer. The findings have implications for many types of cancer.


'/>"/>

Contact: Joe Schwartz
Joe.Schwartz@cornell.edu
607-254-6235
Cornell University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Sequencing hundreds of nuclear genes in the sunflower family now possible
2. Price Family Foundation funds research collaboration between Albert Einstein College of Medicine and University of Oklahoma
3. Price Family Foundation gift will create groundbreaking structural biology institute
4. Study of rodent family tree puts brakes on commonly held understanding of evolution
5. Crown of Venezuelan paramos: A new species from the daisy family, Coespeletia palustris
6. Population Council to present more than 40 studies at International Conference on Family Planning
7. Family Resiliency Center helps study how food-bank clients afford basic non-food items
8. Family matters: Evolutionary relationships among species of magic mushrooms shed light on fungi
9. Family tree of fish yields surprises
10. PatientStream announces the industrys first Multilingual family waiting room board
11. Family studies suggest rare genetic mutations team up to cause schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... OXFORD, Conn. , May 5, 2015, NXT-ID, ... biometric authentication company focused on the growing mobile commerce market, ... the Company,s Chief Technology Officer, is presenting  at CARTES SECURE ... May 5-7, 2015. The three-day conference ... session David is speaking in is themed Global Fraud: ...
(Date:4/27/2015)... 27, 2015 Profile Solutions, Inc. (OTC: PSIQ), ... systems is pleased to announce that Dr Gerry ... and member of its scientific advisory board. ... a thought leader in technology-enhanced learning models. He was ... has published studies and books focused on online student ...
(Date:4/20/2015)... The announcement comes as demand for fire ... Ireland,s foremost records management company, has ... an impressive track record of clients within the first 12 ... management sector in Dubai . As a ... employ a further eight staff members at its Irish headquarters. ...
Breaking Biology News(10 mins):NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3
... called ,pestilences, three are historically recognized as due to ... 19th to 21st centuries AD there were microbiological evidences ... pestis . "For a long time scholars from different ... of the past pandemics. Only ancient DNA analyses carried ...
... , May 9, 2013 Wexford Science & ... in the Wake Forest Innovation Quarter , today ... buildings currently underway represents an additional $150 million investment ... Wexford,s total investment in the Innovation Quarter to more ...
... NY and San Diego, CA A large, multi-institutional research ... a sweeping analysis in the current issue of the journal ... off to direct early human development. Led by Bing Ren ... The Salk Institute for Biological Studies and James Thomson of ...
Cached Biology News:Scientists confirm that the Justinianic Plague was caused by the bacterium Yersinia pestis 2Wexford Science & Technology Makes $150 Million Investment in Wake Forest Innovation Quarter 2Wexford Science & Technology Makes $150 Million Investment in Wake Forest Innovation Quarter 3Mapping the embryonic epigenome 2Mapping the embryonic epigenome 3
(Date:5/27/2015)... Muncie, IN (PRWEB) May 27, 2015 The ... public to join in celebrating National Model Aviation Day. The ... Aviation Day was created to celebrate the model aviation hobby ... AMA encourages all of its approximately 2,350 chartered clubs to ... hosting an event in their communities. There will also be ...
(Date:5/27/2015)... , May 27, 2015 /CNW/ - CQDM, Brain ... close to $8.5M to six (6) multi-disciplinary and multi-provincial ... neuroscience within their Focus on Brain strategic initiative. To ... entities involved as in-kind contributions. This exciting announcement was ... Association for Neuroscience in the presence of Inez Jabalpurwala, ...
(Date:5/27/2015)... 27, 2015 The ALS Therapy ... its wholly owned subsidiary, Anelixis Therapeutics , $1.5 ... ALS that targets the innate immune system. The funding ... Institute received from the 2014 social media phenomenon known ... of $4 million raised directly by the Institute through ...
(Date:5/27/2015)... , May 27, 2015  CytomX, a ... of cancer, today announced the appointments of ... Cynthia Ladd as senior vice president ... was chief financial officer of Onyx Pharmaceuticals, an ... independent consultant and legal counsel to several leading ...
Breaking Biology Technology:Academy of Model Aeronautics Foundation to host National Model Aviation Day Motorcycle Rally and Family Fest in Muncie, IN 2Academy of Model Aeronautics Foundation to host National Model Aviation Day Motorcycle Rally and Family Fest in Muncie, IN 3Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 2Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 3Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 4Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 5Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 6Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 7Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 8Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 9Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 10Ice Bucket Challenge Advances Antibody Toward Clinical Trial for ALS 2Ice Bucket Challenge Advances Antibody Toward Clinical Trial for ALS 3CytomX Expands Executive Leadership Team 2CytomX Expands Executive Leadership Team 3
... ... Technology Platform for Life Sciences Marketing, R&D and Medical Affairs , ... Charlottesville, VA, San Diego, CA, New ... for information and research for life sciences marketing, compliance, R&D and medical affairs announces ...
... , , , ... the launch of QIAGEN,s new QIAsafe DNA Blood Products, the first ... SampleMatrix(R) technology. , , The QIAsafe DNA Blood ... management chain. Biomatrica,s SampleMatrix technology significantly simplifies transport and storage of ...
... RANCHO CORDOVA, Calif., Sept. 9 ThermoGenesis Corp. (Nasdaq: ... and storing adult stem cells, today reported results for the fourth ... For the quarter ended June 30, 2009, the Company reported revenues ... the fourth quarter a year ago. As the Company indicated previously, ...
Cached Biology Technology:OpenQ Secures Investment from Leading Mid-Atlantic Venture Firm 2OpenQ Secures Investment from Leading Mid-Atlantic Venture Firm 3QIAGEN's New Product Line, QIAsafe(R) DNA Blood, has Been Co-Developed With Biomatrica and is Based on Biomatrica's SampleMatrix(R) Technology 2QIAGEN's New Product Line, QIAsafe(R) DNA Blood, has Been Co-Developed With Biomatrica and is Based on Biomatrica's SampleMatrix(R) Technology 3QIAGEN's New Product Line, QIAsafe(R) DNA Blood, has Been Co-Developed With Biomatrica and is Based on Biomatrica's SampleMatrix(R) Technology 4ThermoGenesis Reports Fourth Quarter and Fiscal 2009 Results 2ThermoGenesis Reports Fourth Quarter and Fiscal 2009 Results 3ThermoGenesis Reports Fourth Quarter and Fiscal 2009 Results 4ThermoGenesis Reports Fourth Quarter and Fiscal 2009 Results 5ThermoGenesis Reports Fourth Quarter and Fiscal 2009 Results 6ThermoGenesis Reports Fourth Quarter and Fiscal 2009 Results 7ThermoGenesis Reports Fourth Quarter and Fiscal 2009 Results 8ThermoGenesis Reports Fourth Quarter and Fiscal 2009 Results 9ThermoGenesis Reports Fourth Quarter and Fiscal 2009 Results 10
Human VEGF R3/Flt-4 Phycoerythrin MAb (Clone 54733)...
Immunogen: Synthetic Peptide: V(22) N G H E F E I E G E G E G R(36) Storage: -20 C, Avoid Freeze/Thaw Cycles...
Human beta IG-H3 MAb (Clone 348506) Keywords: BIGH3, betaIG-H3 Protein Family: Extracellular Matrix Molecules...
Human Siglec-9 Biotinylated Affinity Purified Pab...
Biology Products: