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A foot in the door to genetic information
Date:3/7/2012

must be a balance of "wrapped" and unwrapped DNA in the cell nucleus.

Langowski and his coworkers have now been able to resolve these interactions at a highly precise timescale using a novel computer simulation. The researchers observed two different spontaneously occurring open states of which the longer-lived one lasts one hundred thousandth of a second, while the shorter-lived one, during which exactly nine DNA building blocks dissociate from the nucleosome, lasts no more than a few millionths of a second. The group discovered that in both cases the free end of the H3 histone actively moves between protein core and DNA, thus detaching short DNA segments. The investigators assume that once the DNA segments are released from the protein binding, more segments of the DNA thread can be unwrapped more easily.

An interesting observation in this context is that the cell attaches a multitude of chemical, or what is called epigenetic, tags to exactly this free end of the H3 histone. These tags which are often altered in tumor cells have an influence on which genes are read and which are not. "Our observations now also confirm at an atomic level that the H3 tail plays a key role in determining when DNA is accessible and genes can be read and when this is not the case. It is what you could call a foot in the door to access the genetic information," said Langowski interpreting his results.


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Contact: Dr. Sibylle Kohlstaedt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

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