Navigation Links
A foot in the door to genetic information
Date:3/7/2012

In the cell nucleus, DNA wraps around what are called histone proteins, forming regularly spaced spherical bodies called nucleosomes. Thus, large portions of the genetic material are inaccessible to the gene reading machinery. Scientists at the German Cancer Research Center have now simulated at high time resolution how short DNA segments repeatedly detach spontaneously from the nucleosome. The group has been the first to demonstrate that the spool-shaped histone proteins have an active role in opening access to the genetic information.

Histones are evolutionary highly conserved proteins which are much the same in man, mouse or threadworm. They serve as coils around which the DNA molecule, a thread of several feet, wraps in the cell nucleus. Up until recent years, histones were believed to be little more than DNA packaging material. However, by now it is known that they also determine which genes are read and which are not read; thus, they actively participate in regulating many cell functions.

At DKFZ, Professor Dr. Jrg Langowski is studying the interactions of DNA and its "packaging" at a molecular level. "For DNA to be read it must be at least temporarily accessible. We wanted to find out how and, more importantly, for how long histones and DNA thread disassociate from their tightly wrapped state. This gives us a better understanding of how DNA is read and how this mechanism may possibly be disrupted in cancer cells," says Langowski, outlining the goal of his recently published research.

The packaging of DNA in the cell nucleus is extremely well studied: Each DNA spool consists of two molecules each of four different histone proteins. In each nucleosome, a DNA thread of 146 base pairs wraps around this spherical histone complex exactly 1.75 times. A small stretch of unwrapped DNA of variable length is followed by the next histone spool, forming a structure that looks like beads on a string. Prior studies have suggested that there
'/>"/>

Contact: Dr. Sibylle Kohlstaedt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Perception and preference may have genetic link to obesity
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Will a genetic mutation cause trouble? Ask Spliceman
4. Nearby chimpanzee populations show much greater genetic diversity than distant human populations
5. Cleveland Clinic Childrens Hospital launches study to genetically test for autism
6. Genetics of endangered African monkey suggest troubles from warming climate
7. Inherited epigenetics produced record fast evolution
8. Optogenetic tool elucidated
9. Story on human genetic origins is one of EurekAlert!’s most-visited releases in 2011
10. New research shows childhood adversity causes changes in genetics
11. Genetic risk for elevated arsenic toxicity discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... July 30, 2015 Cellecta, Inc., a ... function analysis and biomarker discovery, announced the release ... Library targeting all human protein coding genes. CRISPR ... out" a gene,s function. Cellecta,s new Human Whole ... screening tool so that researchers can investigate in ...
(Date:7/27/2015)... SAN JOSE, Calif. , July 27, 2015 ... leading developer of human interface solutions, today announced ... ClearPad ® touchscreen solution for its stylish ... controller for its proven reliability, low power and ... with a wet finger. Huawei designers also required ...
(Date:7/27/2015)... 2015   Zynx Health ™, the market ... solutions, today announced that its ZynxCarebook ™ ... Android smartphones and tablets. With this expansion, care ... use ZynxCarebook to securely exchange messages and share ... transitions to other care settings, and improve clinical ...
Breaking Biology News(10 mins):CELLECTA, INC. Announces Launch of Human Whole Genome CRISPR Knockout Library 2Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3
... Society (ACS) News Service Weekly PressPac with news from ... credit the individual journal or the American Chemical Society ... ARTICLE #1 FOR IMMEDIATE RELEASE , Hyped-up hopes for ... reporting an advance towards tapping the immense potential of ...
... biomedical researchers from the USC Viterbi School, the College and ... $6-million Bioengineering Research Partnership grant from the National Institutes of ... older adults who suffer from significant vision loss. ... Norberto Grzywacz, professor of biomedical engineering in the Viterbi School ...
... California, Irvine scientists have discovered how to reverse the ... form of mental impairment. Neurobiologist Julie Lauterborn and ... fragile X syndrome blocks brain cells from locking new ... X mental retardation 1 (Fmr1) -- is turned off ...
Cached Biology News:American Chemical Society's Weekly PressPac -- Oct. 3, 2007 2American Chemical Society's Weekly PressPac -- Oct. 3, 2007 3American Chemical Society's Weekly PressPac -- Oct. 3, 2007 4American Chemical Society's Weekly PressPac -- Oct. 3, 2007 5American Chemical Society's Weekly PressPac -- Oct. 3, 2007 6American Chemical Society's Weekly PressPac -- Oct. 3, 2007 7American Chemical Society's Weekly PressPac -- Oct. 3, 2007 8USC biomedical team to participate in $6 million low vision project 2USC biomedical team to participate in $6 million low vision project 3USC biomedical team to participate in $6 million low vision project 4UCI researchers restore memory process in most common form of mental disability 2
(Date:7/30/2015)... ... July 31, 2015 , ... Ralco is honored to announce that ... County Fair to be held August 5-9 in Marshall. The Ralco Enrichment Center is ... from and how agriculture impacts their daily lives. This unique exhibit also features a ...
(Date:7/30/2015)... ATLANTA , July 30, 2015 ... leaders to the 2015 AACC Annual Meeting & ... from July 26–30. The meeting showcased revolutionary ... improves the ability of healthcare providers to diagnose ... get effective medical treatment. As ...
(Date:7/30/2015)... 2015   GenoSpace , a leading provider ... analysis of genomic and other biomedical data, today ... the company as Vice President of Sales and ... "GenoSpace partners with its customers ... and explore complex sets of genomic, phenotypic and ...
(Date:7/30/2015)... USA (PRWEB) , ... July 30, 2015 , ... ... microsystems, has appointed Francois Vieillard as Sales & Marketing Director. , With ... Francois Vieillard will be responsible for reinforcing Tronics’ business development activities worldwide. He ...
Breaking Biology Technology:Ralco Announces Primary Sponsorship of Ralco Enrichment Center at Lyon County Fair 2Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 2Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 3Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 4GenoSpace Introduces Matthew Fischer as Vice President of Sales and Marketing 2Tronics appoints Francois Vieillard as Sales and Marketing Director 2
... (Nasdaq: BMRN ) today announced that Dr. Emil Kakkis, ... 2009. Dr. Kakkis has,decided to leave his position with the ... time to personal endeavors related to rare diseases. Dr.,Kakkis will ... , "I am extremely grateful ...
... Nov. 21 MichBio, the association for,Michigan,s biosciences ... to its fourth annual Expo on Tuesday and ... in Novi, MI. The MichBio Expo is,the ... addition, this year,s event attracted 56 exhibitors. The ...
... Lilly and,Company (NYSE: LLY ) and ImClone Systems ... of the previously announced tender offer,by Lilly,s wholly-owned subsidiary, Alaska ... of $70.00 per share in cash. The,offer expired at ... The depositary for the tender ...
Cached Biology Technology:BioMarin Announces the Planned Retirement of Dr. Emil Kakkis, Chief Medical Officer 2BioMarin Announces the Planned Retirement of Dr. Emil Kakkis, Chief Medical Officer 3BioMarin Announces the Planned Retirement of Dr. Emil Kakkis, Chief Medical Officer 4MichBio Expo Draws Nearly 500 Professionals; Career Day Raises Profile 2MichBio Expo Draws Nearly 500 Professionals; Career Day Raises Profile 3Lilly Completes Cash Tender Offer for ImClone Systems 2Lilly Completes Cash Tender Offer for ImClone Systems 3
... product has been developed to significantly increase ... proteins. Stability is increased at room ... centigrade. This product is subjected to ... or azide. This formulation insures consistently ...
... ThermoStat Plus accurately and conveniently controls the temperature ... maintains different temperature levels up to 99 C*, ... temperatures as low as 5 C. The thermoblocks ... ml tubes, and microplates enable a high degree ...
... developed to significantly increase the shelf life ... is increased at room temperature storage conditions ... product is subjected to 0.2 micron filtration, ... This formulation insures consistently high levels of ...
...
Biology Products: