Navigation Links
A fly mutation suggests a new route for tackling ALS
Date:4/8/2013

researchers discovered a mutation in the mouse, called Wlds, which enables a damaged axon to survive for weeks after injury. "That fundamentally changed how we think about an axon. Under certain circumstances, axons can survive for a much longer time than we have given them credit for," Dr. Freeman explained.

Freeman's laboratory speculated that if axon self-destruction is an active process, then there should be genes in the fly genome whose normal function is to destroy cut axons. They decided if they could break those genes responsible for axon destruction, then the axons shouldn't fall apart. To identify those genes, they performed a labor-intensive screen, randomly breaking genes in the fly genome and looking for those that when broken blocked axon destruction after injury.

This approach led to the identification of one gene, called dSarm, whose normal function is to promote the destruction of the axon after injury. "We got beautiful protection of axons when we knocked out this molecule," Dr. Freeman said. Mice and humans have forms of this gene too, and Freeman and colleagues have shown its functions in a similar way in mice. The preservation of these signaling mechanisms from flies to humans is a sign of evolutionary retention and argues for its importance.

To get closer to applying the axon death gene to the study of disease, the researchers crossed the mouse version of the Sarm mutation into a mouse model that has a type of familial ALS, which is also in humans. Although the mice still lost weight and had difficulty with a mobility test, they lived about 10 days longer than their brethren without the Sarm mutation, and at least half of their motor neurons remained intact. "Since not all the motor neurons are needed," Dr. Freeman said, "even with a 50 percent reduction a patient could feel very close to normal. It would be life-changing for the patient, so it's a step in the right direction."

"We used Wallerian dege
'/>"/>

Contact: Phyllis Edelman
pedelman@genetics-gsa.org
301-634-7302
Genetics Society of America
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Shedding light on a gene mutation that causes signs of premature aging
2. Bird flu mutation study offers vaccine clue
3. One gene, many mutations
4. Found a genetic mutation causing mental retardation very similar to Angelman syndrome in Amish
5. Sleator lab identifies single point mutation in Listeria monocytogenes
6. Why a hereditary anemia is caused by genetic mutation in mechanically sensitive ion channel
7. Mutation altering stability of surface molecule in acid enables H5N1 infection of mammals
8. Research discovers gene mutation causing rare eye disease
9. Animal model of human evolution indicates thick hair mutation emerged 30,000 years ago
10. Consumers have few negative reactions to the results of genetic testing for cancer mutations
11. Mitochondrial mutations: When the cells 2 genomes collide
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... ATLANTA , April 27, 2015  For more ... and trade show has been the premier worldwide event ... Systems 2015 is a must-attend event for any local, ... insight into the emerging commercial markets and current applications ... and innovations of this projected $48 billion industry, and ...
(Date:4/27/2015)... OXFORD, Conn. , Apr. 27, 2015 ... "Company"), a biometric authentication company focused on the growing ... will commence shipping to pre-order customers the first week ... pre-orders through the month of May. ... is a significant milestone for the company as Wocket® ...
(Date:4/27/2015)... 2015 Profile Solutions, Inc. (OTC: PSIQ), a ... is pleased to announce that Dr Gerry Bedore ... member of its scientific advisory board. ... thought leader in technology-enhanced learning models. He was a ... published studies and books focused on online student success ...
Breaking Biology News(10 mins):UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4
... thrive in extreme situations---surviving on toxic chemicals, for instance. ... the American Chemical Society (JACS) May 25, University of ... that: by harnessing other potentially harmful chemicals known as ... , Such insights could lead to new ways of ...
... determined the first detailed molecular images of a piece of ... host cells and initiate the first stages of infection. The ... may help scientists learn new details about how the virus ... potential weak points that can be exploited by novel antiviral ...
... Albert Einstein College of Medicine have discovered a novel ... soon be able to resist the effects of antibiotics ... microbes, including Shigella and E. coli, are rapidly becoming ... led by Dr. John S. Blanchard, the Dan Danciger ...
Cached Biology News:A radical solution for environmental pollution 2Learning how SARS spikes its quarry 2Learning how SARS spikes its quarry 3Einstein researchers identify new way that bacteria develop resistance to antibiotics 2
(Date:4/28/2015)... 2015 The Pistoia Alliance, a global, ... to lower barriers to innovation in R&D, has announced ... , The Ontologies Mapping project has been set up ... ontology management in life sciences R&D. The project will ... guidelines, tools and services to enable the universal application ...
(Date:4/28/2015)... 2015 uBiome, Inc. has announced ... provide clinical tests based on its unique microbial ... startup sparked the era of microbiome-based personalized medicine ... accessible information about their own bodies using the ... microbiome. uBiome has gathered millions of data points ...
(Date:4/28/2015)... More than 50% of patients with ... over the course of their disease, and clinicians are ... the disease progresses. ReachMD , the 24/7 health ... a series dedicated to PD psychosis, featuring interviews and ... and psychiatric conditions. , The new series titled ...
(Date:4/28/2015)... April 28, 2015 IMS is ... bring it to the web and provide greater ... user friendly reporting metrics increase data warehouse’s utility; ... convenient recall and access “on-the-go” makes data analysis ... using client feedback to assist in repository analytics ...
Breaking Biology Technology:Pistoia Alliance Announces Start of Ontologies Mapping Project 2uBiome Launches Clinical Laboratory 2ReachMD Launches Series Focusing on Parkinson’s Disease Psychosis 2
... Wis. Berbee Information Networks Corporation , a ... & Solutions LLC for an undisclosed sum. , ,Berbee said ... firm, bringing it to about 630 employees in all. Strategies ... IBM's iSeries line of business servers. , ,Berbee has ...
... new version of its Mediasite presentation recorder for the Japanese ... date and hopes to create a bigger market. , ,Mediasite ... as a PowerPoint deck with a video of the speaker ... , ,According to company statements the Japanese market is attractive ...
... Manufacturing Company in Racine is providing heat-transfer components ... , the company said on Wednesday. , ,The parts ... company's new hybrid vehicle. Modine's mass heat transfer ... which is the car's main energy source. , ,The ...
Cached Biology Technology:Modine explores making components for fuel cell vehicles 2Modine explores making components for fuel cell vehicles 3