Navigation Links
A fly mutation suggests a new route for tackling ALS
Date:4/8/2013

WASHINGTON, D.C. April 8, 2013 A team of researchers, led by Marc Freeman, PhD, an early career scientist with the Howard Hughes Medical Institute and associate professor of neurobiology at the University of Massachusetts Medical School have discovered a gene in the fruit fly Drosophila melanogaster that, when mutant, blocks the self-destruction of damaged axons, which could hold clues to treating motor neuron diseases, such as amyotrophic lateral sclerosis (ALS).

A neuron has a very distinctive form a bush of dendrites that receive signals, an incredibly long axon, which is like a long tail, and "a little dot" between them that is the cell body, housing the genetic headquarters. Every part of the neuron is required for it to transmit messages. "If anything breaks along any part of the neuron, the cell unplugs from the circuit and no longer functions," explained Dr. Freeman, who presented this research at the Genetics Society of America's 54th Annual Drosophila Research Conference in Washington, D.C.

Once the long tail-like axon is damaged, it shrivels away, basically self-destructing, and resulting in neurons that no longer operate. This catastrophic damage can happen in several ways: from inflammation, a neurodegenerative disease, a metabolic disorder such as diabetes, toxin exposure, or tumor growth. Such axon loss is thought to be a primary factor that leads to functional loss in patients with neurological disorders it is equivalent to going into an electrical circuit and randomly cutting wires.

The study of axon destruction in response to damage goes back to British neurophysiologist Augustus Waller, who in 1850 described how an axon separated from the cell body and cut off from its nutrient supply breaks apart and is dismantled by scavenger cells. "The idea that this process, called Wallerian degeneration, was a passive wasting away of the axon held for 150 years," Dr. Freeman said.

Then in the late 1980s,
'/>"/>

Contact: Phyllis Edelman
pedelman@genetics-gsa.org
301-634-7302
Genetics Society of America
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Shedding light on a gene mutation that causes signs of premature aging
2. Bird flu mutation study offers vaccine clue
3. One gene, many mutations
4. Found a genetic mutation causing mental retardation very similar to Angelman syndrome in Amish
5. Sleator lab identifies single point mutation in Listeria monocytogenes
6. Why a hereditary anemia is caused by genetic mutation in mechanically sensitive ion channel
7. Mutation altering stability of surface molecule in acid enables H5N1 infection of mammals
8. Research discovers gene mutation causing rare eye disease
9. Animal model of human evolution indicates thick hair mutation emerged 30,000 years ago
10. Consumers have few negative reactions to the results of genetic testing for cancer mutations
11. Mitochondrial mutations: When the cells 2 genomes collide
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... of the water window? It consists of radiations in ... absorbed by the water in biological tissues. New theoretical ... radiations within the water window. These could be the ... image of the biological samples or to be used ... the physical mechanism needed to efficiently generate the harmonic ...
(Date:8/21/2014)... standards process, will be available soon and will improve ... in the OnlineFirst version of Nutrition in Clinical ... the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.), ... misconnection that can be harmful and even fatal to ... medical devices, components, and accessories to deliver fluids or ...
(Date:8/21/2014)... a novel and versatile modeling strategy to simulate polyelectrolyte ... as well as for studying polyelectrolytes, including DNA and ... much larger and more complex polyelectrolyte systems, and to ... author of a paper on the work and a ... and Engineering. "This is a big step forward for ...
Breaking Biology News(10 mins):Water window imaging opportunity 2New feeding tube connectors will improve patient safety 2Researchers develop models to study polyelectrolytes, including DNA and RNA 2
... Bats use a combination of cues in their hunting sequence ... to attack, catch and consume and which ones they are ... Eavesdropping bats first listen to their prey, then they assess ... Dr. Rachel Page and her team from the Smithsonian Tropical ...
... Centre of Finland have in collaboration with the University ... Therapies Corp. and Pharmatest Services Ltd, discovered a novel ... and showed that heparin-like compounds can potentially be used ... These findings were published on the Molecular Cancer ...
... the University of Queensland has found a better way to ... to the May issue of the prestigious journal Nature ... called Acacia. Acacia analyses the output of next-generation gene ... Ts and Gs the ,bases, that code for DNA ...
Cached Biology News:What sounds good doesn't always taste good 2New approach to 'spell checking' gene sequences 2
(Date:8/21/2014)... 2014  Four-dimensional (4-D) printing develops materials that ... stimuli such as changes in temperature. This advanced ... in multiple industries.  In the near future, 4-D ... objects ranging from human organs to parts used ... Logo - http://photos.prnewswire.com/prnh/20140820/138289 ...
(Date:8/21/2014)... Bulgaria (PRWEB) August 21, 2014 ... released today by Ontotext . Now the ... semantic analysis of structured and unstructured data is available ... the cost of enterprise technology. Organizations that do not ... for data management can use S4 since there is ...
(Date:8/21/2014)... 2014 SoundConnect , a ... as one of the nation’s Fastest Growing Private ... the 2nd consecutive year. Inc. magazine today ranked ... 500|5000, an exclusive ranking of the nation's fastest-growing ... look at the most important segment of the ...
(Date:8/20/2014)... 2014 Clintrax Global, Inc., a worldwide ... Raleigh, NC , recently announced the ... President of Administration. As Vice ... processes, including their alignment with company objectives and ... as an HR executive, specializing in needs assessments, ...
Breaking Biology Technology:Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 4Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 2SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 3Clintrax Global, Inc. Announces Addition to Executive Team 2
... Pivotal VeraTag(TM) Study ... Initiated ... 4:30 p.m. ET --, SOUTH SAN FRANCISCO, Calif., Oct. 24 Monogram,Biosciences, ... 30, 2007. Third Quarter Results The Company had revenue of $10.4 ...
... Anadys Pharmaceuticals,Inc. (Nasdaq: ANDS ), a biopharmaceutical company ... the areas of hepatitis C and,oncology, announced today that ... November 1, 2007, after the U.S. financial markets,close. ... discuss its third,quarter financial results and operational highlights and ...
... Factors, MUNDELEIN, Ill., Oct. 24 ... has been awarded a hematology contract extension,by ... The,extension agreement provides MedAssets, customers access to ... October,1, 2007, said John Kershaw, President, Sysmex ...
Cached Biology Technology:Monogram Announces Third Quarter 2007 Financial Results 2Monogram Announces Third Quarter 2007 Financial Results 3Monogram Announces Third Quarter 2007 Financial Results 4Monogram Announces Third Quarter 2007 Financial Results 5Monogram Announces Third Quarter 2007 Financial Results 6Monogram Announces Third Quarter 2007 Financial Results 7Monogram Announces Third Quarter 2007 Financial Results 8Monogram Announces Third Quarter 2007 Financial Results 9Monogram Announces Third Quarter 2007 Financial Results 10Monogram Announces Third Quarter 2007 Financial Results 11Monogram Announces Third Quarter 2007 Financial Results 12Monogram Announces Third Quarter 2007 Financial Results 13Anadys Pharmaceuticals to Report Third Quarter 2007 Financial Results 2Sysmex America Awarded MedAssets Supply Chain Systems Hematology Contract Extension 2
... exciting new chapter to a ... Agilents 7890A GC gives you ... your lab to the next ... performance, including advanced separation capabilities, ...
The essence of fluorescence analysis is sensitivity. The high throughput optical system in the RF-5301PC employs a blazed holographic grating, photomultiplier and digital signal processing to provide...
Kit for BASE20/50 dual control unit, includes mounting plate, HOLDER50T, HEATERPAD50, SRTDX temperature probe(s)....
... The transformation of Saccharomyces cerevisiae, as well ... procedure in many molecular biology laboratories. The ... efficiencies with plasmid and linear DNAs using ... made routine plasmid transformations and library screening ...
Biology Products: