Navigation Links
A drug combination extends survival in refractory lung cancer patients
Date:6/2/2011

NEW YORK CITY Scientists have identified a drug combination, when used in advanced lung cancer patients, shows a survival advantage in patients who no longer respond to existing therapies. They found that bexarotene and erlotinib can each repress the critical cell cycle regulator: cyclin D1. The drug combination also broadened the reach to include a specific subset of patients, such as those resistant due to the presence of a ras mutation in their cancer. The study was published in the June issue of Cancer Prevention Research.

"Erlotinib has been found to be most effective in women of Asian descent who are never smokers with bronchioalveolar carcinoma, and who tend to have activating mutations of the epidermal growth factor receptor," said Ethan Dmitrovsky, M.D., an Associate Scientific Director of the Samuel Waxman Cancer Research Foundation and a senior author on the study. "None of the patients in our study fit that demographic profile."

In fact, the patients in the cohort who exhibited the greatest response included non-Asian men who were smokers. Advanced lung cancer patients with refractory disease have a survival of four months or less with traditional chemotherapy. The results of the study showed a median survival of five and a half months and longer. Three patients from the trial are now living two to four years beyond the expected average.

The study's results were recently duplicated by a group of MD Anderson scientists, noted Konstantin Dragnev, M.D., who led this trial and is an associate professor at Dartmouth Medical School, in Hanover, N.H.

The most exciting part of the research, which was funded in part by the Samuel Waxman Cancer Research Foundation, "is that scientists were able to make a dent in the ras mutation subset of patients," said Dmitrovsky, who is a professor at Dartmouth Medical School. "This area is an unmet medical need. These are often times the most difficult lung cancers to treat."'/>"/>

Contact: Jenny Song
jsong@waxmancancer.org
646-398-5277
Samuel Waxman Cancer Research Foundation
Source:Eurekalert

Page: 1 2

Related biology news :

1. Old stain in a new combination
2. Diabetes drug kills cancer stem cells in combination treatment in mice
3. Investigators identify cleat/natural grass combination may be less likely to result in ACL injury
4. Study: Grass, fungus combination affects ecology
5. Grape news: New treatment combination safe alternative to sulfur dioxide
6. Novocure reports data showing TTF therapy in combination with chemotherapy has the potential to increase overall survival for patients with advanced non-small cell lung cancer
7. Pertuzumab and trastuzumab combination improved efficacy for women with HER2-positive breast cancer
8. Combination therapy reduced HER2-positive breast cancers
9. Killing drug-resistant melanoma requires combination therapy
10. Combination therapy provides hope for cure of dangerous infections of cystic fibrosis patients
11. Microbubble-delivered combination therapy eradicates prostate cancer in vivo
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2014)... GARDENS, Fla. , Dec. 3, 2014 /PRNewswire/ ... solutions, today announced that its DigitalPersona ® ... fingerprint readers have been deployed throughout First Bank ... , South Carolina and ... in Southern Pines, North Carolina ...
(Date:11/21/2014)... , November 18, 2014 According ... Market by Systems (Video, RFID, Access Control, Intrusion Detection, ... Hotels, Banks, Government), Component Service Geography - Global Forecasts ... Market is projected to be around $25 Billion in ... 2020, growing at a CAGR of 8.69%. ...
(Date:11/21/2014)... C-Labs LLC, a leading provider of remote ... today announced the appointment of John Traynor ... strategic advisor to the firm, Mr. Traynor will now ... based out of the C-Labs office in ... Muench , Chief Executive Officer. Photo - ...
Breaking Biology News(10 mins):First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2
... Today, farming often involves transporting crops long distances ... corn, Northwest cherries and other produce when they are ... fossil fuel needed to move food that contributes to ... journal Biogeosciences provides a detailed account of how carbon ...
... Water, an increasingly critical resource in the world, factors ... of "Turfgrass Water Conservation," a widely used reference, was ... and water conservation has made significant gains. Now ... the reference book to bring readers, attention to the ...
... Seeking to measure the U.S. first responder community,s ... local levels, the National Institute of Standards and Technology ... will distribute documentary standards to first responders as part ... October 2011. The pilot will help OLES gauge whom ...
Cached Biology News:Carbon hitches a ride from field to market 2Carbon hitches a ride from field to market 3Carbon hitches a ride from field to market 4How to manage turfgrass while conserving water 2It's your standard pilot project: NIST to offer documentary standards to first responders 2
(Date:12/19/2014)... In contrast to traditional LED lights where the ... uses proprietary LED technology to incorporate their spectra in ... is critical in low proximity installations. The Valoya L-series ... lifetime which is up to four times longer than ... cost was clearly higher when compared to traditional fluorescent ...
(Date:12/19/2014)... (PRWEB) December 18, 2014 With only ... time special on Sartorius Biohit products . The ... mLINE pipettes, Picus Electronic Pipette Trade-in Program, and free ... and Safety officers around the world. They are ideal ... Other features include:, ,     Full volume range ...
(Date:12/19/2014)... Dec. 18, 2014 Egenix, Inc. is pleased to ... Chairman of the Board, to succeed Donald Fresne ; ... will continue as a member of the Board.  In recognition ... to the company over almost twenty years, the Board designated ... of Directors has established a Search Committee to find a ...
(Date:12/19/2014)... -- Relmada Therapeutics, Inc. (OTCQB: RLMD), a clinical-stage company ... announced the results of its annual general meeting of ... year in Relmada,s history and it set the stage ... Sergio Traversa , chief executive officer of Relmada. "Over ... human resource and clinical development objectives that position Relmada ...
Breaking Biology Technology:Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2
... International, Inc. (OTCQX: DATA), a technology and services company ... industry, today announced the Company,s selection as a 2011 ... year. "Being once again recognized as ... dedication DATATRAK and its employees have to bringing a ...
... In the computer displays of medical equipment in ... a major role. But a discovery reported from the ... crystal, which have been found to change their ordering ... very low concentrations of a particular bacterial lipid, might ...
... Switzerland, May 20, 2011 Syngenta announced today that ... facility adjacent to its existing research campus in Research ... is scheduled to begin in June 2011, will focus ... innovative solutions to growers across the world.   ...
Cached Biology Technology:DATATRAK Recognized as 2011 Crain's Leading EDGE Award Winner 2Liquid crystal droplets discovered to be exquisitely sensitive to an important bacterial lipid 2Liquid crystal droplets discovered to be exquisitely sensitive to an important bacterial lipid 3Syngenta to Invest in New U.S. Genetics Research Facility 2
EGTA, 50 g. Ethylene glycol-O,O-bis-[2-amino-ethyl]-N,N,N,N,-tetraacetic acid.Assay: > 99.0%. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
RAT ANTI RAT RT1Au (CLASS I POLYMORPHIC) Immunogen: AO lymphoid cells...
Request Info...
Human VEGF R Phycoerythrin Sampler (Cl 89106, 49560, 54733)...
Biology Products: