Navigation Links
A double-barreled immune cell approach for neuroblastoma
Date:11/2/2008

Adding an artificial tumor-specific receptor to immune system cells called T-lymphocytes that target a particular virus extended and improved the cells' ability to fight a form of childhood cancer called neuroblastoma, said researchers form Baylor College of Medicine and Texas Children's Hospital in a report that appears online today in the journal Nature Medicine.

"This is a way to convert a naturally occurring problem into a benefit in treating cancer," said Dr. Malcolm Brenner, director of the Center for Cell and Gene Therapy at BCM, TCH and The Methodist Hospital, and professor of pediatrics and medicine at BCM. He and his colleagues reported on using the new treatment in 11 patients with recurring neuroblastoma. "For the first time, we started to see tumor responses. We have one complete remission and others who have had stable disease for more than a year," said Brenner.

The patients responded after only the one infusion of cells because they last a long time in the body and their numbers can increase, said Brenner.

Previous attempted to use T-lymphocytes with an artificial receptor directed to tumor cells proved disappointing because they disappeared from the body too quickly to have an anti-cancer effect. However, cytotoxic T cells that already have a natural receptor for the Epstein-Barr virus are continually activated by the presence of the virus, which is never eliminated from the body.

Brenner and his group added to these T-lymphocytes a particular receptor for a protein called diasialoganglioside GD2, which is found in human neuroblastoma cells.

"We took the T-lymphocytes' with specificity for Epstein-Barr and added another receptor," said Brenner. "In effect they trampoline off the virus and onto the tumor."

Thus these cytotoxic T-lymphocytes remain in the body because they are constantly stimulated by the virus. Their artificial antigen receptor enables them to latch onto and kill the c
'/>"/>

Contact: Kimberlee Norton
kknorton@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. Mercury pollution causes immune damage to harbor seals
2. Seemingly suicidal stunt is normal rite of passage for immune cells
3. Scripps research team sheds light on immune system suppression
4. Response to immune protein determines pathology of multiple sclerosis
5. Genetic finding implicates innate immune system in major cause of blindness
6. Entertainment Software Association Foundation awards grant to FAS for immune attack
7. Fly studies reveal immune cell responses to tumor and tissue damage
8. Individuals vary their immune response according to age, sex and the costs
9. Immune system protein accurate predictor of survival in pediatric septic shock
10. Pre-eclampsia may be autoimmune disease
11. CMV infections affect more than just patients with compromised immune systems, researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2013)... 2013) - A novel vaccine study from ... research that will be unveiled at the American Association ... meeting takes place Monday, May 20 - Wednesday, May ... , "The main goal of a vaccine is ... pathogen that causes the disease", explained Dr. Hemachand Tummala, ...
(Date:5/20/2013)... Bristol and published online today in the Journal ... brain and inner ear developed in dinosaurs. , ... with Tom Hbner from the Niederschsische Landesmuseum in Hannover, ... dinosaurs. , The two palaeontologists studied different fossils of ... young (juvenile) individual of approximately three years of ...
(Date:5/20/2013)... USA New Geology articles posted ... 2013 cover a wide swath of geoscience subdisciplines, ... geophysics, and paleobotany. Locations studied include Siberia; the ... Alpi Apuane, Italy; Ukraine; Mars; and the Southeastern ... 1. Rubies, jadeite, and plate tectonics;, 2. The ...
Breaking Biology News(10 mins):Germ-fighting vaccine system makes great strides in delivery 2Fossil brain teaser 2New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 2New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 3New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 4New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 5New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 6New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 7New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 8New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 9New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 10New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 11
... in the microbial production of clean, green and renewable ... a new technique in synthetic biology by researchers with ... (JBEI). This new technique dubbed a ,dynamic ... microbes during the production of fatty acid-based fuels or ...
... to turn Arctic and wipe them out, we are witnessing how ... important it is for plants to blossom at the right time ... a powerful affect on how plants flower. In research to be ... Innes Centre on the Norwich Research Park have identified the switch ...
... lung nodules significantly reduce radiation exposure allowing individuals the ... overall lung cancer deaths. This research is being presented ... Meeting in San Francisco, Calif. "The published ... detect lung nodules demonstrated that screening with low-dose CT ...
Cached Biology News:New synthetic biology technique boosts microbial production of diesel fuel 2New synthetic biology technique boosts microbial production of diesel fuel 3New synthetic biology technique boosts microbial production of diesel fuel 4Why spring is blooming marvelous (and climate change makes it earlier) 2Lower dosage CT-guided lung biopsy protocol maintains quality, minimizes exposure 2
(Date:5/19/2013)... May 19, 2013 The JM Internet ... training online, has proudly announced that the company's YouTube ... has surpassed 175,000 views on YouTube. The company uses ... and SEO tips and training for small businesses with ... find the YouTube tips helpful for their SEO strategies", ...
(Date:5/17/2013)... (PRWEB) May 17, 2013 Dr. Sparano ... and Women’s Health at the Albert Einstein College of ... at the Montefiore Medical Center. He is also ... Center and leads the Einstein Breast Cancer Working Group, ... translational breast cancer research. He also serves as Vice ...
(Date:5/17/2013)... Organ transplant rejection occurs when the transplant recipient,s immune ... attacks it. It was previously thought that T cells, ... activated by molecules known as chemokines in order to ... the Journal of Clinical Investigation , Fadi Lakkis ... to demonstrate that chemokine stimulation of T cells is ...
(Date:5/17/2013)... Elsevier, a world-leading provider of scientific, technical and medical ... a recent study in Reproductive BioMedicine Online ... those with an abnormal chromosomal composition can be identified ... blastocysts, thereby classifying the risk of genetic abnormality without ... has undertaken a retrospective study, using their predictive model ...
Breaking Biology Technology:YouTube Channel on SEO Tips Surpasses 175,000 Views, Announces JM Internet Group 2Joseph A. Sparano, MD, Named Vice Chair of ECOG-ACRIN Cancer Research Group 2Joseph A. Sparano, MD, Named Vice Chair of ECOG-ACRIN Cancer Research Group 3Breakthrough for IVF? 2Breakthrough for IVF? 3
... Iceland, October 9, 2011 Scientists at deCODE ... and the USA today report the discovery of low frequency ... gout, a common inflammatory arthritis, and serum uric acid levels. ... is published today in the online edition of Nature ...
... 2011 For the third quarter of 2011, Elekta ... MD Buyline,s user satisfaction surveys by earning the top ... radiosurgery (SRS), linear accelerators (tie with another ... planning systems (TPS). For six consecutive quarters, Elekta has ...
... WINDSOR, England, October 7, 2011 In support ... every pink frame purchased in October. There are over 50 ... To view the full range of pink glasses ... About Breast Cancer Awareness: For women in the ...
Cached Biology Technology:deCODE Genetics, in Collaboration with Academic Colleagues and Illumina, Discovers Two Rare Variants that Affect the Risk of Gout and Serum Uric Acid Levels 2deCODE Genetics, in Collaboration with Academic Colleagues and Illumina, Discovers Two Rare Variants that Affect the Risk of Gout and Serum Uric Acid Levels 3Elekta Ranks as Top Vendor in MD Buyline Report for 3rd Quarter 2011 2Buy Pink Glasses From LensWay and £20 Will be Donated to Breast Cancer Research 2
... Workstation for PCR set-up Easy to assemble ... 0.2 ml PCR tubes, strips or Nunc 96 Well ... Removable tray can be fitted directly into ... ml tube block thermal cycler formats of major manufacturers ...
... 7 cells were cultured in DMEM with 4 ... phase of growth. In order to keep ... fixed in acetone-methanol. The cells are arrayed ... with each wells surface specifically treated to enhance ...
... DMEM and harvested at the log phase of ... in their native forms, cells were fixed in ... 12-well (5 mm) adhesive coated slide, with each ... and to minimize background staining. Each well ...
... Mouse P815 cells were cultured in DMEM and ... In order to keep the antigens in their ... The cells are arrayed on a 12-well (5 ... specifically treated to enhance cellular attachment and to ...
Biology Products: