Park Ridge, Ill. (August 1, 2012) New research from Cornell University indicates that pregnant women who increase choline intake in the third trimester of pregnancy may reduce the risk of the baby developing metabolic and chronic stress-related diseases like high blood pressure and diabetes later in life.(i) The results, published in the latest edition of the Journal of the Federation of American Societies for Experimental Biology, suggest that choline, a nutrient found in high quantities in eggs, may help protect against the effects of a mother's stress during pregnancy. Previous research indicates high exposure to the stress hormone cortisol during pregnancy, often due to maternal anxiety or depression, may make offspring vulnerable to stress-induced illness and chronic conditions.(ii, iii) This finding adds to the growing body of evidence demonstrating the importance of choline in fetal development.
A Closer Look at the Study
Twenty-four women in the third trimester of pregnancy were randomly assigned to consume either 480 milligrams (mg) choline per day or 930 mg per day for 12 weeks prior to delivery. Researchers collected maternal and placental blood samples as well as samples of placental tissue. They then compared cortisol levels and genetic differences among all the samples. The researchers observed lower levels of cortisol in the placental cord and changes in cortisol-regulating genes in both the placental and fetal tissue among women in the higher choline intake group. "The study findings raise the exciting possibility that a higher maternal choline intake may counter some of the adverse effects of prenatal stress on behavioral, neuroendocrine, and metabolic development in the offspring," says Marie Caudill, PhD, Cornell University, who is an author of the study and a leading choline researcher.
Choline: A Vital Nutrient
Choline is especially important for pregnant women it has been shown to
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