Navigation Links
A diabetes drug, sitagliptin, also has a potential to prevent diabetes
Date:3/24/2011

Diabetes type 2 is caused by insufficient levels of insulin to keep blood glucose under control. Excessive levels of another hormone, glucagon, can also contribute to diabetes type 2 by causing the liver to flood the body with stored glucose. Diabetes type 2 does not arise overnight, but slowly progresses for many years as a condition known as prediabetes. In prediabetes, blood sugar rises to excessive levels after a meal, but is normal or nearly normal after an overnight fast. Researchers are seeking ways to prevent prediabetes from progressing to diabetes. Besides diet and exercise, the diabetic drug metformin can slow the onset of diabetes.

In the March 2011 issue of Experimental Biology and Medicine researchers in the Department of Nutrition at Case Western Reserve University determined whether a newer diabetes drug, sitagliptin, might be effective in prediabetes. Sitagliptin works by boosting the levels of an intestinal factor known as GLP-1. This factor increases insulin output while also decreasing glucagon output. They used an animal model with prediabetes, the SHROB rat, which was developed at Case Western Reserve University beginning in the 1970's. These rats are extremely obese and have normal glucose after fasting but high glucose after a meal, like prediabetic humans. Also like prediabetic humans, they have excessive levels of glucagon.

The prediabetic rats were divided into three groups and treated with either a placebo, sitagliptin, or another older diabetes medication, glyburide, which acts by boosting the production of insulin by the pancreas. Sitagliptin and glyburide were equally effective in lowering glucose levels after a meal. Surprisingly, only sitagliptin raised the total output of insulin by the pancreas and only sitagliptin lowered glucagon to normal levels.

Neither of the diabetes medications had any effect on body weight, total body fat or food intake. This matches studies in humans, which show no loss or
'/>"/>

Contact: Dr. Paul Ernsberger
pre@cwru.edu
216-368-4738
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Boston Medical Center receives grant from Astrazeneca to end diabetes
2. Type 2 diabetes linked to single gene mutation in 1 in 10 patients
3. NYU nursing-dental team receives grant to assess effectiveness of A1C diabetes screening technique
4. Missing sugar molecule raises diabetes risk in humans
5. New research suggests that obesity and diabetes are a downside of human evolution
6. La Jolla Institute-led team illuminates cell pathway key to insulin resistance in Type 2 diabetes
7. Culprit found for increased stroke injury with diabetes
8. BUSM researchers uncover cellular mechanism responsible for chronic inflammation, Type 2 diabetes
9. New study suggests almonds may help reduce risk of type 2 diabetes and heart disease
10. Grow your own transplant may be possible for men with type 1 diabetes
11. La Jolla Institute validates Type 1 diabetes computer models predictive success through lab testing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... rumens and termite guts for microbes that can efficiently ... next-generation biofuels, but some of the best microbial candidates ... report. , Their study , reported in the ... is the first to use biochemical approaches to confirm ... digest fiber, breaking it down into simple sugars in ...
(Date:9/23/2014)... Pattern formation is essential in the development of animals ... how can genetic information be translated in a reliable ... , The French-flag model of stripe formation is ... by the different colours of the French flag, is ... i.e. at high, middle or low concentrations of the ...
(Date:9/23/2014)... Research and Markets  has announced the ... Opportunities, 2019" report to their offering. ... security and protection in private as well as government ... government is focusing on using biometric systems to store ... IDs that are of crucial importance to the country. ...
Breaking Biology News(10 mins):Search for better biofuels microbes leads to the human gut 2Search for better biofuels microbes leads to the human gut 3Recreating the stripe patterns found in animals by engineering synthetic gene networks 2India Biometrics Market Forecast and Opportunities, 2019 2India Biometrics Market Forecast and Opportunities, 2019 3
... An improved technique for culturing cells, developed at the ... new, fundamental insights into the behavior of neuronal cells. ... a basic technique for measuring how they respond to ... tasks. Neuronal cells, which make up the central nervous ...
... "dead zone" has formed off the Oregon Coast for the ... State University. , A fundamental new trend in atmospheric and ... begun, scientists say, and apparently is expanding its scope beyond ... effect of the low-oxygen zone is also being seen in ...
... into rheumatoid arthritis (RA), a chronic inflammatory joint disease. ... RA has been linked to an inherited susceptibility. ... siblings seems to be random. , In ... patients with RA, researchers at the University of Michigan ...
Cached Biology News:Neuronal cell cultures kept on the straight and narrow 2Marine 'dead zone' off Oregon is spreading 2Marine 'dead zone' off Oregon is spreading 3New genes implicated in rheumatoid arthritis 2
(Date:9/23/2014)... ANNAPOLIS JUNCTION, MD (PRWEB) September 23, 2014 ... leader in personalized medicine, presented industry leading research and ... this past weekend at the American Academy of ... meeting took place in Phoenix, Arizona at the ... on the linkage between gender and genetic predisposition to ...
(Date:9/23/2014)... - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced ... date to $5 million. The orders are all odour control ... "We continue to see new orders coming in," said ... backlog has climbed to over $11 million." ... technology company that designs, manufactures and distributes a comprehensive line ...
(Date:9/23/2014)... , Sept. 23, 2014 News ... India devoted to genome-based research for ... Genomics (NIBMG) is taking a bite out of oral ... among males in India with the ... solutions from DataDirect Networks (DDN). , To fuel its ...
(Date:9/23/2014)... Texas (PRWEB) September 23, 2014 ... on the Global and China Isopropanol (IPA) industry. ... industry, including definitions, applications and industry chain structure. ... are provided with a focus on history, developments, ... comparison between the international and Chinese situation is ...
Breaking Biology Technology:Proove Biosciences Will Be Exhibiting I.M.P.L.O.R.E Study at the American Academy of Pain Management 25th Annual Meeting 2Proove Biosciences Will Be Exhibiting I.M.P.L.O.R.E Study at the American Academy of Pain Management 25th Annual Meeting 3National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 2National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 3National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 4National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 5(IPA) Isopropanol Industry International & China Development Trend Analysis Now Available at DeepResearchReports.com 2(IPA) Isopropanol Industry International & China Development Trend Analysis Now Available at DeepResearchReports.com 3
... a talk entitled There,s Plenty of Room at the Bottom. ... humans couldn,t manipulate atoms. However, if atomic manipulation is ... How do you know what you have done" , ... IBM and Imago have taken a seminal step along the ...
... Industrial Originally Certified ISO in January 2003 - ... Company They Audited Performed at Such a ... High Quality Level" ... Company Dedicated to Quality, IRVING, Texas, Sept. 6 Carrington,Laboratories, Inc. (Pink Sheets: ...
... Philip Young, Chief Executive Officer,of Osteologix, Inc. ... featured in an exclusive interview with http://www.wallst.net ... 6 at 11 a.m. EDT. The interview will,be ... EDT on September 6. The interview will ...
Cached Biology Technology:IBM and Imago find a crucial difficulty in semiconductor device scaling 2Carrington Reports on ISO 9001:2000 Inspection at Sabila Industrial in Costa Rica 2Carrington Reports on ISO 9001:2000 Inspection at Sabila Industrial in Costa Rica 3WallSt.net (www.wallst.net) Announces Upcoming Interview With CEO of Osteologix 2
...
Recalibration of HL-2000-CAL products...
Mature rat whole blood (Sprague-Dawley, averaging 7-8 weeks of age, either sex) is collected at the time of slaughter and processed within 45 minutes. It is then filtered through gauze, pooled in an ...
Several Pichia pastoris strains are available to allow you to optimize expression and recovery of your protein of interest. Table 1 provides information to help you choose the appropriate strain....
Biology Products: