Navigation Links
A diabetes drug, sitagliptin, also has a potential to prevent diabetes
Date:3/24/2011

Diabetes type 2 is caused by insufficient levels of insulin to keep blood glucose under control. Excessive levels of another hormone, glucagon, can also contribute to diabetes type 2 by causing the liver to flood the body with stored glucose. Diabetes type 2 does not arise overnight, but slowly progresses for many years as a condition known as prediabetes. In prediabetes, blood sugar rises to excessive levels after a meal, but is normal or nearly normal after an overnight fast. Researchers are seeking ways to prevent prediabetes from progressing to diabetes. Besides diet and exercise, the diabetic drug metformin can slow the onset of diabetes.

In the March 2011 issue of Experimental Biology and Medicine researchers in the Department of Nutrition at Case Western Reserve University determined whether a newer diabetes drug, sitagliptin, might be effective in prediabetes. Sitagliptin works by boosting the levels of an intestinal factor known as GLP-1. This factor increases insulin output while also decreasing glucagon output. They used an animal model with prediabetes, the SHROB rat, which was developed at Case Western Reserve University beginning in the 1970's. These rats are extremely obese and have normal glucose after fasting but high glucose after a meal, like prediabetic humans. Also like prediabetic humans, they have excessive levels of glucagon.

The prediabetic rats were divided into three groups and treated with either a placebo, sitagliptin, or another older diabetes medication, glyburide, which acts by boosting the production of insulin by the pancreas. Sitagliptin and glyburide were equally effective in lowering glucose levels after a meal. Surprisingly, only sitagliptin raised the total output of insulin by the pancreas and only sitagliptin lowered glucagon to normal levels.

Neither of the diabetes medications had any effect on body weight, total body fat or food intake. This matches studies in humans, which show no loss or gain of weight from these drugs. But differences appeared when the distribution of body fat was examined. Compared to the older drug glyburide, sitagliptin caused a redistribution of body fat from the abdominal fat deposits to deposits under the skin. Lowering the proportion of fat stored within the abdomen has a number of favorable effects in diabetes and for cardiovascular risk factors. This is the first time that sitagliptin has been found to affect fat distribution, and the cellular basis for this change is an open question.

Group leader Paul Ernsberger, Ph.D., says, "These animal studies suggest that sitagliptin should be tested in the clinic as a possible diabetes-preventing medication. It may act to shore up the function of the pancreas, which deteriorates during the onset of diabetes." Co-investigator Richard J. Koletsky, M.D. says "Sitagliptin's effects on enhancing post prandial insulin secretion and decreasing glucagon secretion offer new pharmacologic interventions to combat diabetes and potentially delay and even prevent its onset."

Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, said "this animal model study by Ernsberger and colleagues suggests that sitagliptin can slow the onset of diabetes. Of great interest is the finding that this drug can redistribute body fat from the abdomen to deposits under the skin."


'/>"/>

Contact: Dr. Paul Ernsberger
pre@cwru.edu
216-368-4738
Society for Experimental Biology and Medicine
Source:Eurekalert

Related biology news :

1. Boston Medical Center receives grant from Astrazeneca to end diabetes
2. Type 2 diabetes linked to single gene mutation in 1 in 10 patients
3. NYU nursing-dental team receives grant to assess effectiveness of A1C diabetes screening technique
4. Missing sugar molecule raises diabetes risk in humans
5. New research suggests that obesity and diabetes are a downside of human evolution
6. La Jolla Institute-led team illuminates cell pathway key to insulin resistance in Type 2 diabetes
7. Culprit found for increased stroke injury with diabetes
8. BUSM researchers uncover cellular mechanism responsible for chronic inflammation, Type 2 diabetes
9. New study suggests almonds may help reduce risk of type 2 diabetes and heart disease
10. Grow your own transplant may be possible for men with type 1 diabetes
11. La Jolla Institute validates Type 1 diabetes computer models predictive success through lab testing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... 2017  Veratad Technologies, LLC ( www.veratad.com ), an ... identity verification solutions, announced today they will participate as ... 15 thru May 17, 2017, in Washington ... Center. Identity impacts the lives of ... quickly evolving digital world, defining identity is critical to ...
(Date:4/18/2017)... Inc., a global expert in SoC-based imaging and computing solutions, has ... features the company,s hybrid codec technology. A demonstration utilizing TeraFaces ® ... be showcased during the upcoming Medtec Japan at Tokyo Big Sight ... Las Vegas Convention Center April 24-27. ... Click here for an image of the ...
(Date:4/11/2017)... DUBLIN , Apr. 11, 2017 Research ... Tracking Market 2017-2021" report to their offering. ... The global eye tracking market to grow at ... The report, Global Eye Tracking Market 2017-2021, has been prepared based ... report covers the market landscape and its growth prospects over the ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... for two-dimensional representations of a complex biological network, a depiction of a system ... big mess,” said Dmitry Korkin, PhD, associate professor of computer science at Worcester ...
(Date:10/12/2017)... ... , ... AMRI, a global contract research, development and manufacturing ... and quality of life, will now be offering its impurity solutions as a ... requirements for all new drug products, including the finalization of ICH M7 earlier ...
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit is back ... 8th June 2018 in San Francisco, CA. The Summit brings together current and former ... CEOs, board directors and government officials from around the world to address key issues ...
(Date:10/11/2017)... ... 11, 2017 , ... A new study published in Fertility ... fresh in vitro fertilization (IVF) transfer cycles. The multi-center matched cohort ... After comparing the results from the fresh and frozen transfer cohorts, the authors ...
Breaking Biology Technology: