Navigation Links
A diabetes drug, sitagliptin, also has a potential to prevent diabetes
Date:3/24/2011

Diabetes type 2 is caused by insufficient levels of insulin to keep blood glucose under control. Excessive levels of another hormone, glucagon, can also contribute to diabetes type 2 by causing the liver to flood the body with stored glucose. Diabetes type 2 does not arise overnight, but slowly progresses for many years as a condition known as prediabetes. In prediabetes, blood sugar rises to excessive levels after a meal, but is normal or nearly normal after an overnight fast. Researchers are seeking ways to prevent prediabetes from progressing to diabetes. Besides diet and exercise, the diabetic drug metformin can slow the onset of diabetes.

In the March 2011 issue of Experimental Biology and Medicine researchers in the Department of Nutrition at Case Western Reserve University determined whether a newer diabetes drug, sitagliptin, might be effective in prediabetes. Sitagliptin works by boosting the levels of an intestinal factor known as GLP-1. This factor increases insulin output while also decreasing glucagon output. They used an animal model with prediabetes, the SHROB rat, which was developed at Case Western Reserve University beginning in the 1970's. These rats are extremely obese and have normal glucose after fasting but high glucose after a meal, like prediabetic humans. Also like prediabetic humans, they have excessive levels of glucagon.

The prediabetic rats were divided into three groups and treated with either a placebo, sitagliptin, or another older diabetes medication, glyburide, which acts by boosting the production of insulin by the pancreas. Sitagliptin and glyburide were equally effective in lowering glucose levels after a meal. Surprisingly, only sitagliptin raised the total output of insulin by the pancreas and only sitagliptin lowered glucagon to normal levels.

Neither of the diabetes medications had any effect on body weight, total body fat or food intake. This matches studies in humans, which show no loss or
'/>"/>

Contact: Dr. Paul Ernsberger
pre@cwru.edu
216-368-4738
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Boston Medical Center receives grant from Astrazeneca to end diabetes
2. Type 2 diabetes linked to single gene mutation in 1 in 10 patients
3. NYU nursing-dental team receives grant to assess effectiveness of A1C diabetes screening technique
4. Missing sugar molecule raises diabetes risk in humans
5. New research suggests that obesity and diabetes are a downside of human evolution
6. La Jolla Institute-led team illuminates cell pathway key to insulin resistance in Type 2 diabetes
7. Culprit found for increased stroke injury with diabetes
8. BUSM researchers uncover cellular mechanism responsible for chronic inflammation, Type 2 diabetes
9. New study suggests almonds may help reduce risk of type 2 diabetes and heart disease
10. Grow your own transplant may be possible for men with type 1 diabetes
11. La Jolla Institute validates Type 1 diabetes computer models predictive success through lab testing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... of bacteria have emerged that resist even the most ... of tuberculosis and staphylococcus, infect more than 2 million ... urgent need for new treatments, scientists have discovered very ... , MIT engineers have now turned a powerful new ... can disable any target gene, they have shown that ...
(Date:9/19/2014)... new resource unveiled today by researchers from several ... Dublin provides both experienced and aspiring researchers with ... and operate robots made from soft, flexible materials. ... laser cutters, and other advances in manufacturing technology, ... field. Using principles drawn from conventional rigid robot ...
(Date:9/19/2014)... Inc. (Nasdaq: NXTD and NXTDW) ("Nxt-ID" or the ... updates the "Wocket in Your Pocket" celebrity ad campaign, featuring former ... classes, Vinny Pazienza (PAZ). , ... actor Ciaran Hinds and Sons of Anarchy ... have been cast in Bleed for This . ...
Breaking Biology News(10 mins):Battling superbugs 2Battling superbugs 3Battling superbugs 4Soft robotics 'toolkit' features everything a robot-maker needs 2NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 2NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 3
... Singapore and Germany have identified that the proteins lamin ... for holding silent genes in their correct position at ... heterochromatin . A deviation from their normal position will ... vascular disease and muscle wasting. 2. For hundreds ...
... Vienna it was impossible not to notice that the blackbirds ... the courtyards of the inner city nor woke tired partygoers ... longer there. Thankfully, they gradually reappeared and a few ... But the sudden crash in numbers was alarming and ...
... by the National Science Foundation with a $400,000 Early ... devices, which promise to improve 3D tissue and cell ... Texas College of Engineering in 2007, has developed a ... cells on microchips. , Her devices produce more accurate ...
Cached Biology News:A*STAR scientists' groundbreaking discovery of nucleus structure crucial to understanding diseases 2Forensic pathology: tracing the origin of the Usutu Virus 2
(Date:9/19/2014)... (Nasdaq: ITMN ) today announced that it ... litigation in the Delaware Court of Chancery relating to ... August 22, 2014, among Roche Holdings, Inc., Klee Acquisition ... Memorandum of Understanding, the Company agreed to make certain ... the amendment to the Company,s Schedule 14D-9 to be ...
(Date:9/19/2014)... (PRWEB) September 19, 2014 ... its potential to revolutionize the world has attracted ... corporations and small start-ups. The early years of ... projects largely due to the high risks involved, ... budgets earmarked for this evolving technology have been ...
(Date:9/19/2014)... SAN DIEGO , Sept. 19, 2014 ... engaged in the development of high-value and difficult to ... will be presenting at the 21 st Annual ... New York . Bertrand Liang , chief ... the company,s development programs and business strategy on Friday, ...
(Date:9/19/2014)... 2014 Dublin ... has announced the addition of the  "Micro Market ... their offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ... the fastest-growing segments in the chromatography market. The ... and expected to reach $2.0 billion by 2019, ...
Breaking Biology Technology:InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 2InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 3InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 4InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 5InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 6InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 7InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 8InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 9InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 10InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 11InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 12InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 13InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 14InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 15InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 16InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 17InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 18InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 19Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 2Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 3Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 4Pfenex to Present at Upcoming Industry Conference on September 26 2Micro Market Monitor : Global Pre-packed Chromatography Columns 2
... Reportlinker.com announces that a new market ... Neurology Devices Market Outlook ... Interventional Neurology and Other ... Market Outlook in China to 2017 – ...
... A team of scientists at Penn State University, the ... developed a method for recreating a schizophrenic patient,s own ... effectively in a Petri dish. The method brings researchers ... schizophrenia. The method also is expected to be used ...
... Researchers here have created the first electronic circuit ... devices that utilize the spin of electrons ... Johnston-Halperin, assistant professor of physics, and his team ... material that is under development in colleague Arthur ...
Cached Biology Technology:Reportlinker Adds Neurology Devices Market Outlook in China to 2017 - Neurostimulation Devices, Interventional Neurology and Other 2Reportlinker Adds Neurology Devices Market Outlook in China to 2017 - Neurostimulation Devices, Interventional Neurology and Other 3Reportlinker Adds Neurology Devices Market Outlook in China to 2017 - Neurostimulation Devices, Interventional Neurology and Other 4Reportlinker Adds Neurology Devices Market Outlook in China to 2017 - Neurostimulation Devices, Interventional Neurology and Other 5Reportlinker Adds Neurology Devices Market Outlook in China to 2017 - Neurostimulation Devices, Interventional Neurology and Other 6Reportlinker Adds Neurology Devices Market Outlook in China to 2017 - Neurostimulation Devices, Interventional Neurology and Other 7Reportlinker Adds Neurology Devices Market Outlook in China to 2017 - Neurostimulation Devices, Interventional Neurology and Other 8Reportlinker Adds Neurology Devices Market Outlook in China to 2017 - Neurostimulation Devices, Interventional Neurology and Other 9Reportlinker Adds Neurology Devices Market Outlook in China to 2017 - Neurostimulation Devices, Interventional Neurology and Other 10Reportlinker Adds Neurology Devices Market Outlook in China to 2017 - Neurostimulation Devices, Interventional Neurology and Other 11Reportlinker Adds Neurology Devices Market Outlook in China to 2017 - Neurostimulation Devices, Interventional Neurology and Other 12Reportlinker Adds Neurology Devices Market Outlook in China to 2017 - Neurostimulation Devices, Interventional Neurology and Other 13Scientists recreate brain cells from skin cells to study schizophrenia safely 2Scientists recreate brain cells from skin cells to study schizophrenia safely 3Researchers advance toward hybrid spintronic computer chips 2Researchers advance toward hybrid spintronic computer chips 3
Recombinant Rat Leptin, CF...
... The CultureWell cell culture ... preparing cultured cells for staining ... use medical-grade silicone gaskets with ... provided sterile and ready to ...
Vybrant® Multidrug Resistance Assay Kit...
... pipets ,Angled acrylic pipet rack offers easy access ... pipet cans. Constructed of 6 mm (1/4 in.) thick ... 76 mm H x 289 mm D (3 x ... W x 406 mm H x 292 mm D ...
Biology Products: