Navigation Links
A detailed look at HIV in action
Date:1/30/2014

or electron microscopy studies of HIV have focused on the virus itself or on infection of laboratory-grown cell cultures," says Bjorkman, who is also an investigator with the Howard Hughes Medical Institute. "Ours is the first major electron microscopy study to look at HIV interacting with other cells in the actual gut tissue of an infected animal model."

By procuring such detailed images, Ladinsky and Bjorkman were able to confirm several observations of HIV made in prior, in vitro studies, including the structure and behavior of the virus as it buds off of infected cells and moves into the surrounding tissue and structural details of HIV budding from cells within an infected tissue. The team also described several novel observations, including the existence of "pools" of HIV in between cells, evidence that HIV can infect new cells both by direct contact or by free viruses in the same tissue, and that pools of HIV can be found deep in the gut.

"The study suggests that an infected cell releases newly formed viruses in a semisynchronous wave pattern," explains Ladinsky. "It doesn't look like one virus buds off and then another in a random way. Rather, it appears that groups of virus bud off from a given cell within a certain time frame and then, a little while later, another group does the same, and then another, and so on."

The team came to this conclusion by identifying single infected cells using electron microscopy. Then they looked for HIV particles at different distances from the original cell and saw that the groups of particles were more mature as their distance from the infected cell increased.

"This finding showed that indeed these cells were producing waves of virus rather than individual ones, which was a neat observation," says Ladinsky.

In addition to producing waves of virus, infected cells are also thought to spread HIV through direct contact with their neighbors. Bjorkman and Ladinsky were able to visualiz
'/>"/>

Contact: Deborah Williams-Hedges
debwms@caltech.edu
626-395-3227
California Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Temp-controlled nanopores may allow detailed blood analysis
2. Detailed Flex Belt Review and Announcement of New Discount Coupon at Flex Belt Critic Site
3. Berkeley Lab researchers get a detailed look at a DNA repair protein in action
4. Scripps Research Institute scientists achieve most detailed picture ever of key part of hepatitis C
5. High-tech X-ray imaging technique to offer detailed look at engineered tissue
6. International Polar Year conference: From knowledge to action
7. Scientists study the catalytic reactions used by plants to split oxygen from water
8. Analysis of stickleback genome sequence catches evolution in action
9. Drug interactions wont exclude HCV transplant or HIV co-infected patients from treatment
10. Yeast cell reaction to Zoloft suggests alternative cause, drug target for depression
11. Support for climate change action drops, Stanford poll finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... 31 de julio de 2015 La 10 th ... celebrará por medio de BGI del 22 al 25 de octubre ... Este año, la conferencia celebra su décimo aniversario. ... convertido en una de las reuniones anuales más influyentes del ... las reuniones más dinámicas, entusiastas y mejores a nivel científico. ...
(Date:7/31/2015)... , Jul. 31, 2015 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market and ... has filed provisional patent 62/198989 for ELECTRONIC ... highlights a method to advance crypto-currencies such as Bitcoin ... a common, uniform way to manage all payments.  ...
(Date:7/30/2015)... Calif. , July 30, 2015 ... services for gene function analysis and biomarker discovery, ... RNA (sgRNA) Knockout Library targeting all human protein ... and permanently "knock out" a gene,s function. Cellecta,s ... a high throughput screening tool so that researchers ...
Breaking Biology News(10 mins):La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 2La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 3NXT-ID Patents Electronic Crypto-Currency Management Technology 2NXT-ID Patents Electronic Crypto-Currency Management Technology 3NXT-ID Patents Electronic Crypto-Currency Management Technology 4CELLECTA, INC. Announces Launch of Human Whole Genome CRISPR Knockout Library 2
... and Ohio State University will battle for the BCS ... week, but if the game was held in the ... halftime. Louisianas wetlands are being lost at the rate ... fight against this rapid destruction, the two universities joined ...
... Creditors are Subject to Identity Theft Red Flag, Legislation ... 1, 2008, BRENTWOOD, Tenn., Jan. 2 With ... of FACTA (Fair and Accurate Transactions Act),also known as ... scrambling to create a written plan for detecting and,responding ...
... Ohio State University have found that the number of copies ... cancer in a mouse model. Publishing in the Jan. 3 ... or Down syndrome in humans, can repress tumor growth. ... whether people with Down syndrome develop cancer less often than ...
Cached Biology News:LSU and Ohio State battle on football field, collaborate in research field 2NXG Strategies Launches Nation's First Website Dedicated to Red Flag Compliance 2Gene dose affects tumor growth 2
(Date:8/26/2015)... ... August 26, 2015 , ... ... today that a second US laboratory is to open in Manhattan, Kansas in ... continued partnership and long-term growth of research and development through collaboration with researchers ...
(Date:8/26/2015)... 26, 2015  The Diabetes Research Institute (DRI), ... Miami Miller School of Medicine, announced today that ... test for the first time a novel transplant ... FDA approved Phase I/II study builds upon decades ... an important first step toward the development of ...
(Date:8/26/2015)... -- China Cord Blood Corporation (NYSE: CO ) ... of cord blood collection, laboratory testing, hematopoietic stem cell ... the Company has been informed that Magnum Opus 2 ... Mr. Yuen Kam, chairman of the board of directors ... "Shares") of  Excellent China Healthcare Investment Limited ("KKR SPV") ...
(Date:8/26/2015)... (PRWEB) , ... August 26, 2015 , ... The 2015 ... Boston adult stem cell technology start-up company Asymmetrex to share the first ... capabilities of a new biomarker for counting adult tissue stem cells. , With a ...
Breaking Biology Technology:MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 2MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 2Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 4China Cord Blood Corporation Receives Notice of Transactions Regarding its 7% Senior Convertible Notes Due 2017 2China Cord Blood Corporation Receives Notice of Transactions Regarding its 7% Senior Convertible Notes Due 2017 3Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 2Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 3Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 4
... You cannot commoditize talent when the key skills for ... have to pay for talent in order to compete ... organizations. , ,There is a misperception that there is ... country. The reality is that there are many qualified, ...
... Rick Davidson Milwaukee, Wis. - Rick ... the word global is in your title, and your company ... blanket - especially in jest. , ,Not that the good-humored ... Manpower , is prone to exaggeration. The Milwaukee-based employment services ...
... - Marshfield Clinic ... management software developed by TeraMedica , a ... as Evercore, will be deployed to integrate all ... images, then distribute them within the clinic's electronic ...
Cached Biology Technology:Getting beyond the vortex of corporate mediocrity 2Getting beyond the vortex of corporate mediocrity 3Getting beyond the vortex of corporate mediocrity 4CIO Leadership Series: Rick Davidson, Manpower 2CIO Leadership Series: Rick Davidson, Manpower 3CIO Leadership Series: Rick Davidson, Manpower 4CIO Leadership Series: Rick Davidson, Manpower 5
Mouse Anti-Human Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 (KIR2DL4 Monoclonal Antibody Family: New...
Mouse monoclonal [7B9] to beta II Tubulin ( Abpromise for all tested applications). Antigen: Synthetic peptide, CEEEEGEDEA found at the c-terminus of beta II tubulin. Entrez GeneID: 10383 ...
Gridded Cell Culture Petri Dish (20 mm molded in base), tissue-culture treated...
...
Biology Products: