Navigation Links
A deeper look into the pathogen responsible for crown gall disease in plants
Date:7/10/2012

Next week's Journal of Biological Chemistry "Paper of the Week" by Wai Mun Huang and colleagues at the University of Utah Health Sciences Center and the University of Minnesota reveals new insights into the molecular properties of the rod-shaped soil bacterium Agrobacterium tumefaciens, the pathogen responsible for crown gall disease, a tumor-forming infection in plants, such as tomatoes, walnuts, grapes and beets.

The bacterium is parasitic: It infects its plant host by entering through an open wound, inserts a small segment of its genetic code into the plant's genome, devours energy made by the plant, and forms knobby brown lesions on the plant stem.

Huang's group focused on the pathogen's genetic material. Most bacteria have circular chromosomes. But A. tumefaciens C58, the strain studied by Huang's group, contains one circular chromosome and one linear chromosome (along with two circular plasmids). Huang's research illuminates how this bacterium maintains its linear chromosome.

Huang's team ascertained the DNA sequence for the telomeres, or the protective end caps, of the linear chromosome in A. tumefaciens C58 and confirmed that an enzyme, TelA, actually forms them by making hairpin loops. These end caps are important for maintaining the stability of linear chromosomes. Interestingly, TelA also binds the telomeres. This activity is unique among bacterial enzymes of this kind and may protect the telomeres (which degrade over time and thus lose their ability to preserve DNA), as telomere binding proteins do in eukaryotes.

"Hairpin-ended linear chromosomes and plasmids are found in a number of branches of bacteria and viruses," Huang says. "They are simple and elegant to form and to maintain." But what remains to be understood is why this linear configuration is not more common or even the preferred configuration for bacteria, Huang emphasizes.


'/>"/>

Contact: Angela Hopp
ahopp@asbmb.org
240-283-6614
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1

Related biology news :

1. Wind pushes plastics deeper into oceans, driving trash estimates up
2. Preserved frogs hold clues to deadly pathogen
3. Antitoxin strategy may help target other pathogens
4. College students work to sterilize air, kill pathogens on buses
5. Bees self-medicate when infected with some pathogens
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. New research finds increased growth responsible for color changes in coral reefs
8. Sports and energy drinks responsible for irreversible damage to teeth
9. Fertilizer use responsible for increase in nitrous oxide in atmosphere
10. Symposium: Protein-Folding Diseases: Models & Mechanisms
11. Small molecule may play big role in Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... , Dec. 22, 2014  The 2014 Holiday Season ... as Acuity Market Intelligence reports that the long anticipated ... forecasts that intensifying demand for smart phones, tablets, and ... global market of 2.5 billion users with nearly 4.8 ...
(Date:12/19/2014)... , Dec. 18, 2014  23andMe, Inc., the leading personal genetics ... fine-scale differences in genetic ancestry of individuals from across ... first arrived more than four hundred years ago, ... place for peoples from different continents. This study illuminates how ...
(Date:12/17/2014)... Dec. 15, 2014 The Defense Logistics Agency is ... and prevent counterfeit microcircuits from entering into its supply ... in-house microcircuit anti-counterfeit initiative dubbed DNA marking. The capability ... their reliability throughout the supply chain. The new quality ...
Breaking Biology News(10 mins):First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 223andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3
... first reported case in Asia of primate-to-human transmission of simian ... primates that so far has not been shown to cause ... monkey to a human took place at a monkey temple ... of the journal Emerging Infectious Diseases. Even though this particular ...
... States Department of Agriculture (USDA) has positively identified the pathogenic ... in Mongolia by field veterinarians from the Wildlife Conservation Society ... occurring in wild migratory birds with no apparent contact to ... for a health survey of wild bird populations in the ...
... modern oceanography is how animals in the deep sea ... Bay Aquarium Research Institute (MBARI) recently published a paper ... that live on the deep seafloor off the coast ... deep-sea video, Bruce Robison and his colleagues found that ...
Cached Biology News:Primate virus jumps species barrier to humans for first time in Asia 2Primate virus jumps species barrier to humans for first time in Asia 3Bird samples from Mongolia confirmed as H5N1 avian flu 2Bird samples from Mongolia confirmed as H5N1 avian flu 3'Sinkers' provide missing piece in deep-sea puzzle 2'Sinkers' provide missing piece in deep-sea puzzle 3'Sinkers' provide missing piece in deep-sea puzzle 4
(Date:1/22/2015)... | RBJ today announces the firm brokered a long-term lease ... leading biopharmaceutical company, at Two Ledgemont Center in ... , president, and Brian Cohen , senior vice president, ... at 95 Hayden Ave. Photo - http://photos.prnewswire.com/prnh/20150122/170765 ...
(Date:1/22/2015)... Protocol Networks brings independent technology consulting ... brand-neutral, independent consultants, Protocol Networks has recently announced its ... the years, his company has attracted several clients in ... as well as others. With the success of these ...
(Date:1/22/2015)... Wilmington, DE (PRWEB) January 22, 2015 ... the Pistoia Alliance, which helps companies check the legal ... set to expand to China. , As their ... companies are globally adopting software solutions built as a ...
(Date:1/22/2015)... 22. 2015  Varian Medical Systems (NYSE: VAR ), ... for its commitment to sustainability with inclusion on a prestigious ... highest ranked healthcare equipment company among the Corporate Knights Global ... Economic Forum at Davos, Switzerland . ...
Breaking Biology Technology:Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2Global Compliance Service for Controlled Substances to Expand to China 2Varian Honored Among World's 100 Most Sustainable Corporations 2
... Madison, Wis. Can a Mac really be hacked in ... University of Wisconsin-Madison systems engineer, who criticized recent media reports for ... which the owner of a computer gave out login accounts to ... for someone who had been given access to the computer to ...
... last week's Fusion2006 was to make information ... that presenters delivered, private-sector CIOs would be well advised ... there was a dominant theme of the second annual ... linkage - linkage with their CEOs and linking information ...
... — Competition is heating up in Waukesha for ... residents. , ,Three firms want to build the infrastructure ... bandwidth to Internet service providers. After waiting several years ... city would start to receive royalties. , ,Midwest Fiber, ...
Cached Biology Technology:IT can't be separate from core business 2
... Rabbit polyclonal to MSY2/YBOX2 ( Abpromise ... Antigen: Synthetic peptide ... the C-terminus of Human MSY2/YBOX2. ... proprietary) (Peptide available ...
...
Request Info...
Purified Mouse anti-Hu LAT (pY226) Storage Temperature: Refrigerate(2 to 8C)...
Biology Products: