Navigation Links
A crystal ball for brain cancer?
Date:7/29/2009

is colleagues focused on glioblastoma, the most common and deadly form of adult brain tumor, striking 12,000 Americans a year. Despite therapy with surgery, radiation and chemotherapy, the average glioblastoma patient lives only 12 to 15 months after diagnosis.

Survival rates drop even lower if the tumor returns. Conventional therapies produce little benefit; only 8 to 15 percent of patients survive without tumor growth six months after treatment.

The UCLA team studied 82 patients who had undergone surgery and radiation therapy to remove glioblastoma. Half of the patients received infusions of Avastin every two weeks. All underwent monthly brain scans by magnetic resonance imaging (MRI) to monitor change.

The researchers analyzed the MRI scans of the patients whose tumors returned. Explaining what the team saw requires an understanding of how the tumor creates an independent blood supply.

Cancer cells secrete a growth factor called VEGF that spurs the growth of new blood vessels to supply the tumor with oxygen and nutrients. Avastin blocks VEGF, essentially starving the tumor to death.

This process launches a chain of events that is detectable by MRI. Oxygen-starved cells produce more VEGF, which causes blood vessels to leak fluids into the tumor and surrounding tissue. This results in swelling, which boosts water's ability to move freely in the tumor and brain tissue. As cells disintegrate, they no longer pose a physical barrier to water movement.

"We theorized that tumors with more water motion would also have higher VEGF levels," explained Pope. "Because Avastin targets VEGF, it made sense that the drug would work better in tumors with high levels of the growth factor."

By measuring the amount of water motion within the tumor, the researchers were able to predict with 70 percent accuracy which patients' tumors would progress within six months and which would not. They detected grea
'/>"/>

Contact: Elaine Schmidt
eschmidt@mednet.ucla.edu
310-794-2272
University of California - Los Angeles
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Researchers develop liquid crystal pharmaceuticals to fight cancer and other diseases
2. Unveiling the structure of microcrystals
3. Liquid crystal phases of tiny DNA molecules point up new scenario for first life on Earth
4. Scientists find missing evolutionary link using tiny fungus crystal
5. New clues to how proteins dissolve and crystallize
6. Crystal (eye) ball: Study says visual system equipped with future seeing powers
7. Scientists demonstrate the sharpest measurement of ice crystals in clouds
8. Photonic crystal biosensors detect protein-DNA interactions
9. Bare bones of crystal growth: Biomolecules enhance metal contents in calcite
10. Heavy pyridine crystallizes differently
11. A crystal clear view of chalk formation
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A crystal ball for brain cancer?
(Date:4/20/2015)... Calif. , April 20, 2015 Huntington ... Gabriel Valley to implant a new miniaturized, wireless monitoring ... System is the first and only FDA-approved heart failure ... hospital admissions when used by physicians to manage heart ... sensor that is implanted in the pulmonary artery (PA) ...
(Date:4/17/2015)... Increasing adoption in ... to drive biometric systems market in ... According to a recently released TechSci Research ... biometric systems market in Saudi Arabia ... CAGR of over 22% through 2020. The market ...
(Date:4/14/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market, announces that its Wocket® ... York Design Awards under the category  ,Product Design – ... Awards are part of a global multi-disciplinary awards program. ... the marketplace, industry and judging panel. Winners will be ...
Breaking Biology News(10 mins):Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3
... Va.Ten million Americans have peripheral arterial disease (PAD), ... include African-Americans (twice as likely to develop clogged ... diabetics (one in three who are over the ... community health and public information programrecommends that older ...
... the southern continents African ostriches, Australian emus and ... do not share a common flightless ancestor as ... flight after diverging from ancestors that did have the ... part by University of Florida zoology professor Edward Braun. ...
... Dust is one of several types of ... poorly understood ways. Dust scatters and absorbs solar radiation, ... cloud formation and other climate-affecting processes. Launch of the ... in 2006 was aimed at improving understanding of how ...
Cached Biology News:At risk for peripheral arterial disease? Simple quiz provides key so you can circulate better 2At risk for peripheral arterial disease? Simple quiz provides key so you can circulate better 3New research challenges long-held assumptions of flightless bird evolution 2AGU journal highlights -- Sept. 3, 2008 2AGU journal highlights -- Sept. 3, 2008 3AGU journal highlights -- Sept. 3, 2008 4AGU journal highlights -- Sept. 3, 2008 5AGU journal highlights -- Sept. 3, 2008 6AGU journal highlights -- Sept. 3, 2008 7
(Date:4/23/2015)... , April 23, 2015 BioTE Medical ... his book "Age Healthier Live Happier - Avoiding Over-Medication ... the Age Management Medicine Group Conference at JW Marriott ... 2015. ",Age Healthier Live Happier, is a ... avoid over-medication and searching for a higher quality of ...
(Date:4/23/2015)... 23, 2015 Follow us ... a series of genetic tests that determine individual ... Gehrig's disease, Huntington's disease, and Alzheimer's disease. Predictive ... composition and interaction in diseased tissue/cells to understand ... as the response to treatment, such as in ...
(Date:4/23/2015)... 23, 2015 Glemser Technologies ... first EMC® Enterprise Content Division (ECD) Certified Solution ... EMC Documentum® for Life Sciences Solution Suite . ... and capabilities to provide life sciences companies of ... , The EMC Documentum Solution Suite offers four ...
(Date:4/23/2015)... 23, 2015 /PRNewswire/ - Crystal Research Associates, LLC announced ... ® (EIO) on Aeterna Zentaris Inc. (NASDAQ: ... on Crystal Research Associates, website at www.crystalra.com ... at www.aezsinc.com . Aeterna Zentaris ("Aeterna" ... company in oncology, endocrinology, and women,s health. With a ...
Breaking Biology Technology:Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 2Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 3Increasing Disease Prevalence & Focus on Preventive Healthcare Drive the Predictive Diagnostics Market, According to a New Report by Global Industry Analysts, Inc. 2Increasing Disease Prevalence & Focus on Preventive Healthcare Drive the Predictive Diagnostics Market, According to a New Report by Global Industry Analysts, Inc. 3Glemser Earns Accreditation for Life Sciences Solution Suite 2Crystal Research Associates, LLC Issues Executive Informational Overview (EIO) on Aeterna Zentaris Inc. 2Crystal Research Associates, LLC Issues Executive Informational Overview (EIO) on Aeterna Zentaris Inc. 3
... Eureka Moment concerning the fractal character of neurons ... genomics where protein structures act back recursively upon ... prevailing orthodoxy. A household name in neuroscience ... has recently had another far-reaching discovery borne out.,This ...
... PAREXEL International,Corporation (Nasdaq: PRXL ), a ... has promoted Mark A. Goldberg, M.D.,to Chief Operating ... Clinical Research Services and Perceptive Informatics at,PAREXEL. He ... Company and report,to Josef von Rickenbach, Chairman and ...
... In a statement released today, Bud,Hayden, a director ... privately,held Minneapolis-based integrative life science company, announced Raj,Khankari, ... CEO on August 1, 2008., (Photo: ... from CIMA Labs Inc., a Cephalon company,where he ...
Cached Biology Technology:Principle of Recursive Genome Function Supersedes Dogmas; By Andras Pellionisz, Online Ahead of Print; (Scientific Visionary Vindicated) 2Principle of Recursive Genome Function Supersedes Dogmas; By Andras Pellionisz, Online Ahead of Print; (Scientific Visionary Vindicated) 3Principle of Recursive Genome Function Supersedes Dogmas; By Andras Pellionisz, Online Ahead of Print; (Scientific Visionary Vindicated) 4Principle of Recursive Genome Function Supersedes Dogmas; By Andras Pellionisz, Online Ahead of Print; (Scientific Visionary Vindicated) 5PAREXEL Promotes Dr. Mark A. Goldberg to Chief Operating Officer 2PAREXEL Promotes Dr. Mark A. Goldberg to Chief Operating Officer 3PAREXEL Promotes Dr. Mark A. Goldberg to Chief Operating Officer 4Raj Khankari Named Bioenergy, Inc., CEO 2
MBS 384 well satellite block unit with height adjusting heated lid, 384 well block holds 1 x 0.04 ml 384 well plate...
Multidrop DW is a high-speed automated dispenser for Deep Well plates, 1.1 ml test tubes and 96-well plates. Designed for accuracy and precision, the Multidrop DW dispenses up to eight different reag...
ma. plate stack height 70mm...
... MBS Satellite Thermal Cycler (MBS) ... solution for medium to high ... combines the latest in satellite ... and PC control, resulting in ...
Biology Products: