Navigation Links
A collaboration solves the herpes virus protein structure providing new drug therapy directions
Date:7/26/2010

PHILADELPHIA - The mechanism by which a herpes virus invades cells has remained a mystery to scientists, but now research from Tufts University and the University of Pennsylvania reveals the unusual structure of a key member of the protein complex that allows a herpes virus to invade cells.

The new map details an essential piece of the herpes virus "cell-entry machinery," providing scientists with a new target for antiviral drugs.

The research was published online in the journal Nature Structural & Molecular Biology.

Researchers at Tufts and Penn used X-ray crystallography along with cell microscopy techniques to study the structure and function of the cell-entry protein fusion events carried out by HSV-2. The research has resulted in a map of an important protein complex required to trigger herpes virus infection, setting the stage for new therapeutics that may prevent the virus's access to cells.

Most viruses need cell-entry proteins called fusogens in order to invade cells. Scientists have known that the herpes virus fusogen does not act alone, requiring a complex of two other viral cell-entry proteins. In this study, researchers determined the structure of this key protein complex and realized it did not resemble the structure of other known fusogens.

"This unexpected result leads us to believe that this protein complex is not a fusogen itself but that it regulates the fusogen," said senior author Ekaterina Heldwein, assistant professor of molecular and microbiology at Tufts University School of Medicine. "We also found that certain antibodies interfere with the ability of this protein complex to bind to the fusogen, evidence that antiviral drugs that target this interaction could prevent viral infection."

"We hope that determining the structure of this essential piece of the herpes virus cell-entry machinery will help us answer some of the many questions about how herpes virus initiate
'/>"/>

Contact: Jordan Reese
jreese@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. NTU ramps up collaboration with Israels top university
2. Chinese-German collaboration yields new species of Large Blue butterfly
3. JDRF, Pfizer, Hadassah Medical and the Hebrew University announce collaboration
4. Penn joins international collaboration in government and academics to research soft matter
5. The Full Yield, Inc. Launches Breakthrough Collaboration to Put Food Back at the Heart of Healthcare
6. Mexico-US collaboration launched to study major human diseases
7. Chiltern Announces Collaboration With Dr Nawab Qizilbash
8. ESA and World Bank move toward closer collaboration
9. Penn, Georgia collaboration awarded $14.6 million to expand pathogen database
10. Synthetic biology offers new opportunities for interdisciplinary collaboration
11. NanoString Technologies announces research collaboration with the Broad Institute
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A collaboration solves the herpes virus protein structure providing new drug therapy directions
(Date:9/18/2014)... probably the ultimate form of camouflage: you don,t just ... strategy is not as uncommon as you might think. ... USA, explains that the larval life stages of many ... of the anatomy that most creatures cannot make transparent. ... to shield each individual eye unit with an opaque ...
(Date:9/18/2014)... Clownfish spend their entire lives nestling in the protective ... as babies they sometimes travel hundreds of kilometres across ... by reef fish has been predicted, this is the ... between distant populations has been observed. , Dr Steve ... at the University of Exeter, and colleagues from the ...
(Date:9/17/2014)... the creation of the Santa Ana Wildfire Threat Index ... potential of the powerful, hot, dry Santa Ana wind, ... index was introduced Sept. 17 by the U.S. Forest ... and Electric. , The index includes four classification levels ... to help fire agencies and other emergency responders, the ...
Breaking Biology News(10 mins):Transparent larvae hide opaque eyes behind reflections 2Expedition finds Nemo can travel great distances to connect populations 2Expedition finds Nemo can travel great distances to connect populations 3UCLA scientists play key role in developing new Santa Ana Wildfire Threat Index 2
... close relative of the Formosan "super termite" that's gnawing ... established in South Florida, according to University of Florida ... in tropical areas such as Brazil and the West ... to Florida until now," said Nan-Yao Su, a professor ...
... geneticist Harvey D. Blackburn is responsible for collecting and ... semen and embryos -- to make sure there's enough ... of his collection deals with important livestock such as ... the collections Blackburn, who is the coordinator of the ...
... has found that one of the cell's largest families ... regulate the development of nerve cells, also controls nerve ... learning and memory. These findings, the first to link ... appear in the May issue of Nature Cell Biology, ...
Cached Biology News:Cousin of Asian super termite invades Florida 2Making Sure Sacred Sheep Don't Become Extinct 2Structure-building cell signals also may influence learning and memory 2Structure-building cell signals also may influence learning and memory 3
(Date:9/18/2014)... 18, 2014 Texas Governor Rick ... Texas A&M Health Science Center CEO Brett Giroir, ... Health and Human Services (HHS), State of Texas ... pandemic influenza vaccine manufacturing facility in Bryan, Texas, ... for the Texas A&M Biocorridor – a rapidly ...
(Date:9/18/2014)... -- Research and Markets has announced the ... Industry Report, 2014-2017" report to their offering. ... can differentiate into specialized cells and can divide (through ... can be applied to treatment of cardiovascular diseases, leukemia ... damage or lesion of liver, kidney and other parenchymal ...
(Date:9/18/2014)... , Sept. 18, 2014 Research ... "Global Human Albumin Industry Report 2014" report ... Albumin Industry Report 2014 is a professional and in-depth ... albumin industry. The report provides a basic ... industry chain structure. The human albumin market analysis is ...
(Date:9/18/2014)... Leatherwood Plastics has selected Vycom’s ... stay competitive in the semiconductor, clean room and ... impact product quality and productivity, according to Dwight ... in 1980 in Lewisville, TX, Leatherwood Plastics ... left the business. Much of Leatherwood’s equipment building ...
Breaking Biology Technology:Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 2Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 3Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 4Global and Chinese Stem Cell Industry Report, 2014-2017 2Global and Chinese Stem Cell Industry Report, 2014-2017 3Global Human Albumin Industry Report 2014 2Global Human Albumin Industry Report 2014 3Leatherwood Plastics Selects Vycom’s Flametec PVC-C Material to Stay Competitive in Semiconductor and Lab Equipment Industries 2
... OAKS, Calif., Nov. 1, 2010 Amgen (Nasdaq: ... Miletich, M.D., Ph.D., will urge members of a U.S. Food ... for biosimilars to establish approval standards that ensure patient safety ... and sound policy will follow," Dr. Miletich said.  "Amgen believes ...
... N.J., Nov. 1, 2010 PharmaNet Development Group, Inc., ... biotechnology, generic drug and medical device companies, today announced ... topics during the 9th Annual Partnerships in Clinical Trials ... in Vienna, Austria.   At the conference, ...
... today the company will present the results of a Week-24 ... in treatment-naive patients with chronic genotype 1 hepatitis C virus ... for the Study of Liver Diseases (AASLD) in Boston, MA., ... late-breaker oral presentation on Monday, November 1.   ...
Cached Biology Technology:Amgen to Provide Testimony at FDA Hearing on Biosimilars 2Amgen to Provide Testimony at FDA Hearing on Biosimilars 3Amgen to Provide Testimony at FDA Hearing on Biosimilars 4PharmaNet Development Group Experts to Share Insights at the 9th Annual Partnerships in Clinical Trials Conference in Vienna 2Week-24 Interim Results From Phase 2b PILLAR Study to be Presented as Late-Breaker at AASLD 2Week-24 Interim Results From Phase 2b PILLAR Study to be Presented as Late-Breaker at AASLD 3Week-24 Interim Results From Phase 2b PILLAR Study to be Presented as Late-Breaker at AASLD 4