Navigation Links
A coating for life

Stents that keep weakened and flabby arteries from collapsing have been true life-savers. But after six months, those stents are no longer needed -- once the arteries are strengthened, they become unnecessary. Previously, doctors had no choice but to leave them in place.

Prof. Meital Zilberman of Tel Aviv University's Department of Biomedical Engineering has developed a new patent-pending fiber platform that carries drugs where they're needed, then dissolves.

"Our new composite fibers consist of a strong core coated with a drug-releasing, or 'eluting,' solution. They combine strength with the desired elements necessary for drug delivery, so they can be used as the basis of biodegradable drug-eluting stents," says Prof. Zilberman.

Her unique coating technology, she adds, can be used to coat both metal stents, which are currently available, and the biodegradable stents now in development.

Controlling the flow

"The main problem with drugs used on stents is that coating manufacturers have been unable to develop a method for releasing them in a controlled manner," explains Prof. Zilberman. Insoluble in water, these drugs do not release well from a coating, she explains. A coating made from an extremely porous structure like hers, however, provides a large surface area for diffusion. This gives heart specialists "a desired release profile."

Pre-programmed to release the drugs in a controlled manner, Dr. Zilberman's patent-pending fibres can also be designed to dissolve within a precise number of months, so the stent can do its work, then disappear.

Fibers to mend cancers and brain tumors

Prof. Zilberman says that her biodegradable drug-eluting fibers only five times the thickness of a human hair can be applied in cancer treatments as well, particularly for cancers in hard to reach and sensitive areas such as in the brain, or in small children, she notes.

"When you take a tumor out of the brain, you can't 'clean' the surrounding brain tissue -- attempts to do so may lead to additional tissue damage. But if you left our biodegradable drug-loaded fiber in the brain, it could do the work, then disappear when it's no longer needed," she says.

And since the fibres are thin and delicate, Prof. Zilberman adds, laparoscopic methods can be used for their insertion, further increasing the chances for a full recovery.

So far, Prof. Zilberman and her Ph.D. student Amir Kraitzer have conducted biological experiments using an anti-cancer drug developed at TAU by Prof. Yoel Kloog, dean of the Faculty of Life Sciences, and the results have been very encouraging.

Prof. Zilberman is continuing her work on her feasibility studies in both stenting and in cancer. Meanwhile the applications of this novel technology multiply as fast as she can imagine them: Prof. Zilberman has also developed a bone growth scaffold and dissolvable wound healing application, both derived from this basic research.


Contact: George Hunka
American Friends of Tel Aviv University

Related biology news :

1. Candy-coating keeps proteins sweet
2. Coating improves electrical stimulation therapy used for Parkinsons, depression, chronic pain
3. Coating copies microscopic biological surfaces
4. Nanoscale coating protect products -- and the economy
5. New polymer coatings prevent corrosion, even when scratched
6. Ultra-fine coatings on sediment grains influence nitrate and sulfate storage in soil
7. University researchers to develop coatings that kill superbugs
8. Corrosion-inhibiting coatings containing good bacteria
9. Non-toxic hull coating resists barnacles, may save ship owners millions
10. Sugarcoating fruit fly development
11. Nontoxic hull coating resists barnacles, may save ship owners millions
Post Your Comments:
Related Image:
A coating for life
(Date:11/17/2015)... , Nov. 17, 2015  Vigilant Solutions announces ... joined its Board of Directors. --> ... after recently retiring from the partnership at TPG Capital, ... companies with over $140 Billion in revenue.  He founded ... across all the TPG companies, from 1997 to 2013.  ...
(Date:11/12/2015)... CAMBRIDGE, Mass. , Nov. 12, 2015 /PRNewswire/ ... Broad Institute of MIT and Harvard for use ... chemical discovery information management tools. The partnership will ... share both biological and chemical research information internally ... tools will be used for managing the Institute,s ...
(Date:11/10/2015)... Nov. 10, 2015 About ... that helps to identify and verify the identity ... considered as the secure and accurate method of ... a particular individual because each individual,s signature is ... especially when dynamic signature of an individual is ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... SAN DIEGO , Nov. 24, 2015 Halozyme Therapeutics, ... Jaffray Healthcare Conference in New York on ... Dr. Helen Torley , president and CEO, will provide a ... New York at 1:00 p.m. ET/10:00 a.m. ... communication and investor relations, will provide a corporate overview. --> ...
(Date:11/24/2015)... ... 2015 , ... International Society for Pharmaceutical Engineering (ISPE) closed ... events for pharmaceutical manufacturing: 2015 Annual Meeting. The conference took place in Philadelphia, ... number of attendees in more than a decade. , “The 2015 Annual ...
(Date:11/24/2015)... India , November 24, 2015 ... a new market research report "Oligonucleotide Synthesis Market by ... Application (PCR, Gene Synthesis, Diagnostic, DNA, RNAi), End-User (Research, ... 2020", published by MarketsandMarkets, the market is expected to ... Million in 2015, at a CAGR of 10.1% during ...
(Date:11/24/2015)... Massachusetts , November 24, 2015 SHPG ... will participate in the Piper Jaffray 27 th Annual Healthcare ... Tuesday, December 1, 2015, at 8:30 a.m. EST (1:30 p.m. GMT). ... , Chief Financial Officer, will participate in the Piper Jaffray 27 ... , NY on Tuesday, December 1, 2015, at 8:30 a.m. ...
Breaking Biology Technology: