Navigation Links
A cluster bomb for cancer care

Chemotherapy, while an effective cancer treatment, also brings debilitating side effects such as nausea, liver toxicity and a battered immune system.

Now, a new way to deliver this life-saving therapy to cancer patients ― getting straight to the source of the disease has been invented by Dr. Dan Peer of Tel Aviv University's Department of Cell Research and Immunology and the Center for Nano Science and Nano Technology together with Prof. Rimona Margalit of the Department of Biochemistry and Molecular Biology.

Drs. Peer and Margalit have developed a nano-sized vehicle with the ability to deliver chemotherapy drugs directly into cancer cells while avoiding interaction with healthy cells, increasing the efficiency of chemotherapeutic treatment while reducing its side effects.

"The vehicle is very similar to a cluster bomb," explains Dr. Peer. Inside the nano-vehicle itself are tiny particles of chemotherapy drugs. When the delivery vehicle comes into contact with cancer cells, it releases the chemotherapeutic payload directly into the cell. According to Dr. Peer, the nanomedical device can be used to treat many different types of cancer, including lung, blood, colon, breast, ovarian, pancreatic, and even several types of brain cancers.

Their technological breakthrough was recently reported in the journal Biomaterials.

A sweet payload to trick cancer

The key to the drug delivery platform is the molecule used to create the outer coating of this cluster nano-vehicle, a sugar recognized by receptors on many types of cancer cells. "When the nano-vehicle interacts with the receptor on the cancerous cell, the receptor undergoes a structural change and the chemotherapy payload is released directly into the cancer cell," says Dr. Peer, which leads to more focused chemotherapeutic treatment against the diseased cells.

Because the nano-vehicle reacts only to cancer cells, the healthy cells that surround them remain untouched and unaffected by the therapy. The nano-vehicle itself, adds Dr. Peer, is made from organic materials which fully decompose in the body once it has performed its function, making the treatment safer than current therapies.

Clinical trials coming soon

This drug will be an improvement on anything currently on the market, says Dr. Peer. Delivering chemotherapeutics directly into cancerous cells themselves is not only more potent, but also much safer.

Drs. Peer and Margalit are working with ORUUS Pharma in California, which has licensed the "cluster bomb" platform from the university and can ensure a quick transition from the lab to clinical trials, which should begin in two years or less, says Dr. Peer.


Contact: George Hunka
American Friends of Tel Aviv University

Related biology news :

1. Tufts wins NCRR grant for Collaborative Cluster in Genome Structure and Developmental Patterning
2. Autism Speaks responds to recent publications citing autism clusters in California
3. Nature study demonstrates that bacterial clotting depends on clustering
4. Understanding cancer using the fruit fly
5. Protein made by breast cancer gene purified
6. Scientists find new twist on drug screening to treat common childhood cancer
7. MSU project may lead to new approaches against lung cancer
8. New mechanisms of tumor resistance to targeted therapy in lung cancer are discovered
9. Research could change course of treatment for cancer that spreads to bones
10. New breast cancer committee to establish federal research agenda
11. Gallbladder cancer may be linked to estrogens, says UH team
Post Your Comments:
Related Image:
A cluster bomb for cancer care
(Date:10/29/2015)... ARBOR, Mich. , Oct. 29, 2015 /PRNewswire/ ... Eurofins Genomics for U.S. distribution of its DNA ... DNA-seq kit and Rubicon,s new ThruPLEX Plasma-seq kit. ... to enable the preparation of NGS libraries for ... plasma for diagnostic and prognostic applications in cancer ...
(Date:10/27/2015)... 27, 2015 Munich, Germany ... Mapping technology (ASGM) automatically maps data from mobile eye ... , so that they can be quantitatively analyzed ... Munich, Germany , October 28-29, 2015. SMI,s ... from mobile eye tracking videos created with SMI,s ...
(Date:10/23/2015)... , Oct. 23, 2015 Research and ... the "Global Voice Recognition Biometrics Market 2015-2019" ... --> The global voice recognition biometrics ... 2014-2019. --> --> ... has been prepared based on an in-depth market analysis ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... , Nov. 24, 2015  Clintrax Global, Inc., a worldwide provider ... , today announced that the company has set a new ... 391% quarter on quarter growth posted for Q3 of 2014 to ... and Mexico , with the establishment of an ... 2015. --> United Kingdom and ...
(Date:11/24/2015)... LEXINGTON, Massachusetts , November 24, 2015 ... Officer, will participate in the Piper Jaffray 27 th Annual ... on Tuesday, December 1, 2015, at 8:30 a.m. EST (1:30 p.m. ... Poulton , Chief Financial Officer, will participate in the Piper Jaffray ... City , NY on Tuesday, December 1, 2015, at 8:30 ...
(Date:11/24/2015)... SAN FRANCISCO , Nov. 24, 2015 /PRNewswire/ ... today announced that Emily Leproust, Ph.D., Twist Bioscience ... Piper Jaffray Healthcare Conference on December 1, 2015 ... Palace Hotel in New York City. ... . Twist Bioscience is on ...
(Date:11/24/2015)... - ProMetic Life Sciences Inc. (TSX: PLI) (OTCQX: PFSCF) ("ProMetic" ... , President and Chief Executive Officer of ProMetic, will be ... th Annual Healthcare Conference to be held at the ... st , at 8.50am (ET) and ProMetic,s management team ... presentation will be available live via a webcast accessible at ...
Breaking Biology Technology: