Navigation Links
A clue to the GI problems that plague many kids with autism?
Date:1/11/2012

January 11, 2012 -- New research conducted in the Center for Infection and Immunity (CII) at Columbia University's Mailman School of Public Health, reports that children with autism and gastrointestinal disturbances have high levels of a bacterium called Sutterella in their intestines.

Study findings are published online in the journal mBio.

The investigators found that over half of the children diagnosed with autism and gastrointestinal disturbances had Sutterella in intestinal biopsy tissue, while Sutterella was absent in biopsies from typically developing children with gastrointestinal disturbances. Not only was Sutterella present in the intestines of children with autism, but relative to most genera of bacteria, Sutterella was present at remarkably high levels. Sutterella species have been isolated from human infections previous to this study, but it remains unclear whether this bacterium is a human pathogen.

"These findings shine a light on a bacterium about which we know very little, in a disorder for which we have few answers," says Brent Williams, PhD, the lead author on the study. "There is much work to be done toward understanding the role Sutterella plays in autism, the microbiota, infections, and inflammation."

The researchers examined intestinal biopsies from 32 patients, 23 diagnosed with autism and 9 typically developing children. While previous studies investigating a link between the microbiota and autism have utilized stool samples, the study was unique in investigating bacteria adherent to the intestinal wall, which may be different than what is shed in the stool. Furthermore, the researchers designed and applied novel Sutterella-specific molecular assays to enable detection, quantitation, and phylogenetic analysis of Sutterella species in biological and environmental samples.

Many children with autism have gastrointestinal problems that can complicate clinical management and contribute to behavioral disturbances. However, the underlying reason that autism is associated with gastrointestinal disturbances is unknown.

"Although caution in interpretation is indicated because this is a small cohort, microbiome research may provide new insights into gastrointestinal disturbances that develop in children with autism," notes Mady Hornig, MD, Mailman School associate professor and director of Translational Research at the CII.


'/>"/>
Contact: Stephanie Berger
sb2247@columbia.edu
212-305-4372
Columbia University's Mailman School of Public Health
Source:Eurekalert

Related biology news :

1. Study IDs new genetic links to impulsivity, alcohol problems in men
2. Improved living environments can reduce health problems for women and children
3. Poor growth, delayed puberty and heart problems plague kids with mild kidney disease
4. Rate of chronic health problems for low-birth-weight children does not increase in adolescence
5. Air pollution linked to learning and memory problems, depression
6. Solving the puzzle of cognitive problems caused by HIV infection
7. Study finds therapies using induced pluripotent stem cells could encounter immune rejection problems
8. Fibroids cause womens lower urinary tract problems: uterine fibroid embolization helps
9. Experts examine problems and advances in blood supply safety and screening
10. Stigma weighs heavily on obese people, contributing to greater health problems
11. OHSU fixes complex heart problems without open-heart surgery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/6/2017)... LONDON , April 6, 2017 ... Control, RFID, ANPR, Document Readers, by End-Use (Transportation & ... Energy Facility, Oil, Gas & Fossil Generation Facility, Nuclear ... Healthcare, Educational, Other) Are you looking for ... Authentication sector? ...
(Date:4/5/2017)... YORK , April 5, 2017 Today ... is announcing that the server component of the HYPR ... known for providing the end-to-end security architecture that empowers ... HYPR has already secured over 15 million ... makers including manufacturers of connected home product suites and ...
(Date:4/4/2017)... --  EyeLock LLC , a leader of iris-based identity ... and Trademark Office (USPTO) has issued U.S. Patent No. ... iris image with a face image acquired in sequence ... th issued patent. "The issuance ... multi-modal biometric capabilities that have recently come to market ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... ... October 09, 2017 , ... The award-winning American Farmer ... first quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. , With ... with the challenge of how to continue to feed a growing nation. At the ...
(Date:10/9/2017)... ... October 09, 2017 , ... The Giving Tree Wellness ... targeting the needs of consumers who are incorporating medical marijuana into their wellness ... Arizona. , As operators of two successful Valley dispensaries, The Giving Tree’s two ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... instruments and applications consulting for microscopy and surface analysis, Nanoscience Instruments is ... Nanoscience Analytical offers a broad range of contract analysis services for advanced ...
(Date:10/7/2017)... 2017  The 2017 Nobel Prize in Chemistry ... Dubochet, Joachim Frank and Richard ... microscopy (cryo-EM) have helped to broaden the ... community. The winners worked with systems manufactured by ... highly resolved, three-dimensional images of protein structures that ...
Breaking Biology Technology: