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A chaperone system guides tail-anchored membrane proteins to their destined membrane
Date:7/5/2011

l and their release at the membrane. The two receptor proteins Get1 and Get2 aid in TA protein insertion. They use overlapping interfaces for the interaction with the Get3 ATPase. On the basis of different crystal structures the researchers suggest a model for the mechanism of how TA proteins are inserted into the membrane. Upon interaction with its membrane receptor the Get3 dimer gradually opens up to allow for the controlled TA protein insertion. "Those results are particularly important because they enabled us to establish the first model of the receptor-assisted membrane insertion of TA proteins that will now be the basis for further studies" comments Dtsch.

Publication Stefer, S. et al: Structural basis for tail-anchored membrane protein biogenesis by the Get3-receptor complex, Science (2011), DOI: 10.1126/science.1207125.


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Contact: Prof. Volker Dtsch
vdoetsch@em.uni-frankfurt.de
49-697-982-9631
Goethe University Frankfurt
Source:Eurekalert  

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