Navigation Links
A cell's first steps: Building a model to explain how cells grow
Date:5/18/2012

A collaboration between Lehigh University physicists and University of Miami biologists addresses an important fundamental question in basic cell biology: How do living cells figure out when and where to grow?

The teams of Assistant Professor Dimitrios Vavylonis and Associate Professor Fulvia Verde discovered that protein Cdc42 oscillates throughout yeast cells, precipitating a ballet of proteins that change its polarity. By changing polarity, Cdc42 regulates shape, structure and function in yeast cells, starting the growth process by clustering in an area of the cellular membrane. The oscillatory mechanism they found may be a general strategy among all self-organizing biological systems, not just simple yeast.

"The research is fundamental because it provides science with an important answer to how a living cell controls its growth process," said Vavylonis. "Knowing how this particular protein controls growth could in the long run affect the search for drugs to control cell growth for tissue regeneration, organ development, and explain how neurons extend in different directions."

This work indicates how Cdc42 activates bipolar growth only once a minimal cell length has been achieved. At that point, Cdc42 begins to oscillate back and forth through the cell, as the two tips compete for it. Using fluorescent markers to tag each of the many proteins involved, researchers observed the Cdc42 protein oscillate from side to side within a cell, switching sides about every five minutes. The fluctuations provide an adaptable mechanism for cells to control their size and structure in the fast-changing environment within.

The study, Oscillatory Dynamics of Cdc42 GTPase In The Control of Polarized Growth, appears today in the journal Science.

The findings demonstrate just part of the complex process of cell growth and differentiation, but mark how advanced the science of biophysics has become. Only recently has the cl
'/>"/>

Contact: Jordan Reese
jor310@lehigh.edu
610-758-6656
Lehigh University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Nature: Microscope looks into cells of living fish
2. New York Stem Cell Foundation scientist grows bone from human embryonic stem cells
3. IBNs Droplet Array sheds light on drug-resistant cancer stem cells
4. Creating energy from light and air - new research on biofuel cells
5. Scientists identify prostate cancer stem cells among low-PSA cells
6. MicroRNA controls malignancy and resistance of breast cancer cells
7. Study discovers genetic pathway impacting the spread of cancer cells
8. When cells hit the wall: UCLA engineers put the squeeze on cells to diagnose disease
9. Molecular spectroscopy tracks living mammalian cells in real time as they differentiate
10. Housekeeping mechanism for brain stem cells discovered
11. BU researchers derive purified lung and thyroid progenitors from embryonic stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A cell's first steps: Building a model to explain how cells grow
(Date:11/5/2014)... Fidel Santamaria, associate professor of biology in the ... researchers in the nation selected to receive a ... Grant for Exploratory Research (EAGER). The funding supports ... support researchers to create new technology that will ... Santamaria, complex behaviors in neuroscience are broken into ...
(Date:11/4/2014)... 2014 – University of Utah engineers developed the first ... fuel produce electricity without needing to ignite the fuel. ... portable electronics, off-grid power and sensors. , A study ... American Chemical Society journal ACS Catalysis . , ... reaction between a fuel and an oxygen-rich source such ...
(Date:11/4/2014)... (November 4, 2014) — Think about the way our ... do neighboring cells know that they are supposed to ... do these tissues find the correct place and alignment? ... these crucial questions. , In a new study, UM ... communicate with their surrounding neighbors, at the head-trunk region. ...
Breaking Biology News(10 mins):UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3Jet-fueled electricity at room temperature 2The inside story: How the brain and skull stay together 2
... diabetes during pregnancy is directly controlled by serotonin, a ... a neurotransmitter, and is influenced by the amount of ... to new findings of an international team led by ... to simple dietary solutions and possible therapeutics for the ...
... rich? Smithsonian researchers have new evidence that the answer ... to a study published in the journal, Nature ., ... not grow and survive well under their mothers or other ... fellow at the University of WisconsinMilwaukee and the Smithsonian Tropical ...
... available in Spanish . , At a time ... Service (ARS)-funded scientists have contributed to a limited but growing ... cognitive function. Cognitive function is measured by the ... use available information for activities of daily life. Alzheimer,s disease, ...
Cached Biology News:Gestational diabetes linked to serotonin and dietary protein 2Gestational diabetes linked to serotonin and dietary protein 3Biodiversity's holy grail is in the soil 2Vitamin D and mental agility in elders 2
(Date:11/24/2014)... -- Last week, Representatives Gus Bilirakis (R-FL) ... bold bipartisan step on behalf of patients with ... co-sponsors of the legislation include Representatives McCaul (R-TX) ... makers and innovators to "repurpose" major market drugs ... opens the door to the development of hundreds ...
(Date:11/24/2014)... MD (PRWEB) November 24, 2014 ... underrepresented patient populations into clinical trials at its ... , “Continental was created with the idea ... play a fundamental role in medical advances," said ... Tuskegee syphilis experiment to the immortal cell line ...
(Date:11/23/2014)... 23, 2014 Apiscent Labs, a ... fine chemical ingredients to the global pharmaceutical and ... its new website, Apiscent.com. , The Apiscent.com homepage ... clean design, easy navigation, rotating images and content ... stand out. , The company’s work ...
(Date:11/22/2014)... 21, 2014 RURO, Inc., a ... has released Limfinity® version 5.1.4. , RURO’s deployment ... Limfinity® than ever in RURO’s 8 year history. ... framework enhancement. Limfinity® version 5.1.4 is the perfect ... beyond bug fixes! , Limfinity® 5.1.4 release highlights ...
Breaking Biology Technology:OPEN Act Introduced to Repurpose Drugs for Rare Diseases 2At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 2At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 3RURO Announces Limfinity® version 5.1.4 2
... S.A., a,French drug and diagnostic discovery company, today announces ... 2007., 2007 Key Events, - Milestone reached ... AGN ) in view of the initiation of Phase ... - Approval by the AFSSAPS (Agence Francaise de ...
... Germany, March 5 In mid-March the German,Bundestag (Lower ... the German Stem,Cell Act. The opposing poles in the ... apart: its proponents are calling for the complete,liberalisation of ... of a,general ban on the use of human stem ...
... Statins Alone, in Decreasing Cardiovascular Events in Diabetics with Haptoglobin ... ... March 5 Synvista,Therapeutics, Inc. (Amex: SYI ) announces the publication ... E to statin therapy prevented more cardiovascular events (heart,attack, stroke and cardiovascular ...
Cached Biology Technology:ExonHit Therapeutics - 2007 Financial Results 2ExonHit Therapeutics - 2007 Financial Results 3ExonHit Therapeutics - 2007 Financial Results 4ExonHit Therapeutics - 2007 Financial Results 5ExonHit Therapeutics - 2007 Financial Results 6ExonHit Therapeutics - 2007 Financial Results 7ExonHit Therapeutics - 2007 Financial Results 8ExonHit Therapeutics - 2007 Financial Results 9ExonHit Therapeutics - 2007 Financial Results 10ExonHit Therapeutics - 2007 Financial Results 11ExonHit Therapeutics - 2007 Financial Results 12A New Era in Cell Biology: German Company Develops Groundbreaking Alternative to Stem Cell Therapy 2A New Era in Cell Biology: German Company Develops Groundbreaking Alternative to Stem Cell Therapy 3Synvista Therapeutics Highlights Newly Published Data Demonstrating the Value of Haptoglobin Genotype Testing In People with Diabetes 2Synvista Therapeutics Highlights Newly Published Data Demonstrating the Value of Haptoglobin Genotype Testing In People with Diabetes 3Synvista Therapeutics Highlights Newly Published Data Demonstrating the Value of Haptoglobin Genotype Testing In People with Diabetes 4
... These handy dispensers save space and ... and other garb. They are the ... parts used in labs, processing and ... charges and the particles they attract. ...
...
... microRNA expression profiling and built on ... on-chip synthesis platform. These microarrays are ... microRNA Expression Profiling Service. ... Microarray contains all known arabidopsis microRNAs ...
... Microarrays designed for genome-wide microRNA ... flexible and powerful Paraflo microfluidic on-chip ... as part of our comprehensive microRNA ... Content The Viruses microRNA Microarray ...
Biology Products: