Navigation Links
A built-in strategy for transgene containment
Date:3/18/2008

Zhejiang University, Hangzhou, China. A method of creating selective terminable transgenic rice was reported by the scientists of Zhejiang University in this weeks PLoS ONE. Unintended spreading of transgenic rice by pollen and seed dispersal is a major concern for planting transgenic rice, especially transgenic rice expressing pharmaceutical or industrial proteins.

The transgenic rice plants created in the past usually can only be detected by sophisticated molecular detection methods and it is prohibitedly difficult to identify and selectively kill the transgenic rice plants once they escape into environments and contaminate conventional rice.

However, with the technology reported by Dr. Zhicheng Shens group, the transgenic rice plants mixed in the conventional rice could be selectively eliminated by a spray of Bentazon, an herbicide commonly used for rice weed control.

This technology appears to be quite simple, reliable and inexpensive for implementation. If you use Bentazon for weed control in your rice field, you do not need to worry about any possible contamination caused by transgenic rice created by our method. The herbicide will take care of it said Dr. Shen, the corresponding author of the article. Containment of transgenic crops only by physical isolation is not sufficient in our view, as human errors, animal activities and nature accidents will lead to the spreading of transgenic rice plants sooner or later added Chaoyang Lin, graduate student in Dr. Shens laboratory and one of the leading contributors of the article. Indeed, several major accidents of unintended spreading of the transgenic crops did happen in the past several years in USA.

This technology may be best for use to contain transgenic rice as bioreactors. While all biotech products today are safe and nutritious, this technology could allow certain crops targeted for industrial, energy or health uses to be grown under controlled conditions and kept separate from other channels said Nick Duck Vice President of Research for Athenix Corp. in the USA.

The principle beneath this strategy is elegant and simple according to the article. The genes of interest in these transgenic rice plants will be linked with an RNAi cassette which suppresses the expression of the rice detoxification enzyme of Bentazon, rendering the transgenic rice to be sensitive to the herbicide. Conventional rice is highly tolerant to Bentazon.

Dr. Shens lab is currently using the technology for developing transgenic rice as well as corn for expression of industrial enzymes and pharmaceutical proteins. We believe that transgenic crops are the future, and we feel much better knowing that we may release selectively terminable transgenic plants in the future to address the concern of transgene spreading, said Dr. Shen.


'/>"/>

Contact: Dr. Zhicheng Shen
zcshen@zju.edu.cn
Public Library of Science
Source:Eurekalert

Related biology news :

1. Built-in exercise monitor predicts fitness
2. A screening strategy using zebrafish targets genes that protect against hearing loss
3. ETH Zurich competence center ESC introduces energy strategy
4. Strategy for nanotechnology-related environmental, health and safety research
5. Carbon capture strategy could lead to emission-free cars
6. Texas Hospital nations first to use large-scale cocoon strategy against whooping cough
7. New screening strategy for detection of chagas disease in children
8. Lupus Research Institute strategy delivers $30 million in national funding
9. Bee strategy helps servers run more sweetly
10. Penn Veterinary Medicine report new strategy to create genetically-modified animals
11. Embryonic stem cell strategy advanced with UCSF finding
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/4/2017)... BLOOMINGTON, Ill. , Oct. 4, 2017  GCE Solutions, a ... powerful new data and document anonymization solution on October 4, 2017. ... the pharmaceutical field to comply with policy 0070 of the European ... documents and data. ... Innovation by GCE Solutions ...
(Date:8/15/2017)... Aug. 15 2017   ivWatch LLC , a medical device ... therapy, today announced receipt of its ISO 13485 Certification, the global ... International Organization for Standardization (ISO®). ... ivWatch Model 400 Continuous Monitoring device for the early detection of ... "This is an important milestone ...
(Date:6/30/2017)... Today, American Trucking Associations announced Seeing ... and eye tracking software, became the newest member ... "Artificial intelligence and advanced sensing algorithms ... driver,s attentiveness levels while on the road.  Drivers ... fatigue and prevent potential accidents, which could lead ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... multicenter, prospective clinical study that demonstrates the accuracy of the FebriDx® test, ... clinically significant acute bacterial and viral respiratory tract infections by testing the ...
(Date:10/11/2017)... ... October 11, 2017 , ... At its national board ... Suneel I. Sheikh, the co-founder, CEO and chief research scientist of Minnesota-based Advanced ... for membership in ARCS Alumni Hall of Fame . ASTER Labs is ...
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia Inc ., ... a Webinar titled, “Pathology is going digital. Is your lab ready?” with Dr. ... best practices and how Proscia improves lab economics and realizes an increase in ...
(Date:10/11/2017)... ... October 11, 2017 , ... A new study published in ... and fresh in vitro fertilization (IVF) transfer cycles. The multi-center matched ... , After comparing the results from the fresh and frozen transfer cohorts, the ...
Breaking Biology Technology: