Navigation Links
A budding role for a cellular dynamo
Date:2/18/2009

Waltham, MAActin, a globular protein found in all eukaryotic cells, is a workhorse that varies remarkably little from baker's yeast to the human body. Part of the cytoskeleton, actin assembles into networks of filaments that give the cell structural plasticity while driving many essential functions, from cell motility and division, to vesicle and organelle transport within the cell. In a groundbreaking new study in the current issue of Developmental Cell, Brandeis researchers raise the curtain on how this actin maintains just the right filament length to keep the cell healthy and happily dividing.

Using baker's yeast as the model organism, Brandeis researchers Melissa Chesarone, Christopher Gould, and James Moseley, all in the lab of biologist Bruce Goode, set out to discover how the length of actin fibers is controlled. By answering this question, the scientists sought to advance understanding of asymmetrical cell division, a process that not only allows yeast to divide, but also ensures the proper renewal of human stem cells and plays a crucial role in early stages of embryonic development.

In yeast cells, as in all other cells, actin fibers serve as internal "railways" or tracks that give the cell directionality and provide the wherewithal for transporting various molecular and membrane-bound cargoes from one end of the cell to the other. Molecular machines called formins produce many of the actin fibers, but in the absence of a displacement factor to put a brake on the process, formins will essentially stop at nothing, producing excessively long actin filaments at ridiculously fast rates, and wreaking cellular havoc, says Goode. In humans, genetic defects in formins are associated with conditions such as infertility and deafness.

"We wanted to know how you turn the formins off. What disrupts the interaction of the formin with the actin filament, thus terminating actin assembly and regulating its length?" Goode explained.'/>"/>

Contact: Laura Gardner
gardner@brandeis.edu
781-736-4204
Brandeis University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Tuning in on cellular communication in the fruit fly
2. Researchers identify new function of protein in cellular respiration
3. Dictyostelium cells shown to lay breadcrumb trail as first step in multicellular formation
4. Johns Hopkins researchers detect sweet cacophony while listening to cellular cross-talk
5. Columbia to award 2008 Horwitz Prize to Arthur Horwich & Ulrich Hartl for cellular protein folding
6. UC San Diego bioengineers fill holes in science of cellular self-organization
7. A new cellular pathway linked to cancer is identified by NYU researchers
8. Cellular self-eating promotes pancreatitis
9. LIAI researchers discover new cellular mechanism that will significantly advance vaccine development
10. Researchers discover critical detail of cellular defense against genetic mistakes
11. Genome of marine organism tells of humans unicellular ancestors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2015)... JOSE, Calif. , July 13, 2015 /PRNewswire/ ... leading developer of human interface solutions, today announced ... generation touch and display driver integration (TDDI) product ... is the first to combine Synaptics , ... with proven display driver technology developed in the ...
(Date:7/9/2015)... , July 07, 2015 ... the addition of the "Biometrics for Banking; ... 2015-2020" report to their offering. ... contributor to this growth and the forecast is ... in revenue for companies involved in delivering biometric ...
(Date:7/8/2015)... , July 8, 2015 Summary Pancreatic ... the fourth most fatal, with a mortality rate of ... prognosis of pancreatic cancer patients has highlighted a significant ... is not being met by the current market. ... of products with varying molecule types and mechanisms of ...
Breaking Biology News(10 mins):Synaptics Announces Sampling of Second Generation TDDI Solutions 2Synaptics Announces Sampling of Second Generation TDDI Solutions 3Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 2Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 3
... When a person develops a sore or a boil, it ... infection. Then it resolves and flattens into the skin, often ... scenario plays out in the blood vessels. However, when there ... of blood vessels to recover from inflammation atherosclerosis or ...
... you eat right and exercise regularly, chances are high that ... thanks to new findings by researchers from Harvard and Baylor, ... studies recently published online in The FASEB Journal ... have the potential to save millions of lives. Both ...
... The Stowers Institute,s Shilatifard Lab has identified a new role ... polymerase II (Pol II) the enzyme that synthesizes ... protein-synthesizing machinery of the cell. Precise control of the ... essential for development. In a paper published online in the ...
Cached Biology News:Failure to bridle inflammation spurs atherosclerosis 2New discoveries from Harvard and Baylor get to the heart of cardiovascular disease 2New discoveries from Harvard and Baylor get to the heart of cardiovascular disease 3
(Date:7/29/2015)... , July 29, 2015 /PRNewswire/ - Aeterna Zentaris Inc. ... it has selected an optimized Erk inhibitor molecule ... the development of a new class of potential ... represents a prime target for therapeutic intervention in ... and survival benefits for B-Raf and Mek inhibitors. ...
(Date:7/29/2015)... ... July 29, 2015 , ... CSSi LifeSciences™ ... CRO specializing in Clinical Trial Management. CSSi LifeSciences is specialized in strategic, marketing, ... of PRC Clinical is focused on Clinical Trial Management, Clinical Site Monitoring, and ...
(Date:7/29/2015)... (PRWEB) , ... July 29, 2015 , ... Costello served ... levee system to protect the Orange County, Texas area from future storm surge ... design team in determining several potential levee alignment alternatives for providing protection, Costello also ...
(Date:7/29/2015)... ... 2015 , ... Asymmetrex, LLC founder and director ... full range of capabilities of its unique cache of technologies for identifying, quantifying, ... renewal and repair of normal tissues and organs. This property makes them the ...
Breaking Biology Technology:Aeterna Zentaris Announces Optimized Erk Inhibitor Compounds For Further Development 2Aeterna Zentaris Announces Optimized Erk Inhibitor Compounds For Further Development 3CSSi LifeSciences And PRC Clinical Join Forces To Offer Extended Clinical Trial Services 2CSSi LifeSciences And PRC Clinical Join Forces To Offer Extended Clinical Trial Services 3Preventing Storm Surge Flooding in Houston 2Asymmetrex Plans to Report Results From Adult Stem Cell Technology Development Milestone Studies At End of Summer 2Asymmetrex Plans to Report Results From Adult Stem Cell Technology Development Milestone Studies At End of Summer 3Asymmetrex Plans to Report Results From Adult Stem Cell Technology Development Milestone Studies At End of Summer 4
... can be avoidedATLANTA, Jan. 30 For the many women ... help after this week,s birth of octuplets in California, ... be prevented with today,s advanced technologies."Infertility affects 7.3 million ... be pregnant to do is shy away from infertility ...
... In the electronics industry, thin metal films are deposited ... ions atoms with a positive charge to knock ... Department of Energy,s Lawrence Berkeley National Laboratory have now developed ... high-quality metal films in complex, three-dimensional nanoscale patterns at a ...
... NKTR ) announced today that Irwin Lerner has ... Mr. Lerner, former Chairman of,Hoffmann-La Roche Inc., has been a ... is retiring due to personal reasons. , ... acknowledge the,contributions that Mr. Lerner has made by providing the ...
Cached Biology Technology:You Want To Have a Baby...But Not Eight 2A supercharged metal-ion generator 2A supercharged metal-ion generator 3A supercharged metal-ion generator 4A supercharged metal-ion generator 5
... derivative of Taq DNA polymerase. It is ... polymerase. Expressed from a gene construct in ... the 5'-3' exonuclease domain of the DNA ... active and even more heat-stable DNA polymerase ...
...
Homo sapiens similar to Cytosolic acyl coenzyme A thioester hydrolase Antigen: Peptide...
Borrelia Burgdorfen (IgG) -Ab EIA Sample Size: 100 l...
Biology Products: