Navigation Links
A breath of fresh air could improve drug toxicity screening
Date:9/2/2009

ound that liver cells grown with endothelial cells in a serum-free culture with 95 percent oxygen quickly resume normal metabolic activity, including gene expression and cell function. These cultured cells successfully predicted the clearance rates for both rapid- and slow-acting drugs and maintained a high level of metabolic activity for several weeks.

"This is a significant achievement," says Martin Yarmush, MD, PhD, director of the MGH Center for Engineering in Medicine and a co-author of the PNAS study. "Oxygen had been thought to affect cell survival but not gene expression or the function of cultured liver cells. This all changed when we started looking at new formations of culture media." Yarmush is the Helen Andrus Benedict Professor of Surgery at Harvard Medical School, where Nahmias is an instructor in Bioengineering.

The new culture system is being licensed to HμREL Corporation of Beverly Hills, Calif., a company developing human-relevant models of drug metabolism. Future work will explore extending these results to other cell systems and clinical applications, such as transplantation of liver cells.


'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2

Related biology news :

1. Severe breathing disorders during sleep are associated with an increased risk of dying
2. Holding breath for several minutes elevates marker for brain damage
3. When children have breathing problems
4. Methane-eating microbes can use iron and manganese oxides to breathe
5. A breath mint made from... coffee?
6. Effects of maternal exercise on fetal breathing movements
7. Effects of maternal exercise on fetal breathing movements
8. Microscope reveals how bacteria breathe toxic metals
9. Stomach ulcer bug causes bad breath
10. OSAs ISP launches with research on breathing disorders and congenital heart defects
11. National Jewish Health researchers evaluating treatment to help emphysema sufferers breathe easier
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... explored the type and number of connections in transcription ... on robustness in a study published in PLOS ... that the assortativity signature contributes to a network,s resilience ... varying the out-out assortativity of TFN models has a ... other three types of assortativity," said Dov A. Pechenick, ...
(Date:8/29/2014)... of marine phytoplankton, such as the prolific bloomer ... (thiamine), researchers have discovered. The finding contradicts the common ... eukaryotic microbes depend on scarce supplies of thiamine in ... way to think about the ocean," says CIFAR Senior ... ISME Journal paper with CIFAR fellows John ...
(Date:8/29/2014)... - The rise of the Tibetan plateau -- the ... is important for both its profound effect on climate ... published in GSA Bulletin , Katharine Huntington and ... thermometry -- using modern and fossil snail shells to ... southwestern Tibet. , Views range widely on the ...
Breaking Biology News(10 mins):Assortativity signatures of transcription factor networks contribute to robustness 2Not all phytoplankton in the ocean need to take their vitamins 2Not all phytoplankton in the ocean need to take their vitamins 3Snails tell of the rise and fall of the Tibetan Plateau 2Snails tell of the rise and fall of the Tibetan Plateau 3Snails tell of the rise and fall of the Tibetan Plateau 4Snails tell of the rise and fall of the Tibetan Plateau 5Snails tell of the rise and fall of the Tibetan Plateau 6Snails tell of the rise and fall of the Tibetan Plateau 7
... The Netherlands, December 15 WCC Services, the,leading ... announced that,version 6 of its flagship product, ELISE, ... may receive hundreds of applicants for,each job opening ... for the job.,Security concerns are also at peak ...
... Society for Microbiology (ASM) has been honored with non-profit ... its public outreach initiatives. The awards were announced ... Society,s MicrobeWorld Video series received the award for best ... series strives to increase public understanding and appreciation of ...
... GeneVision: the uncanny ability to view the activity of ... modified camera. With GeneVision, military commanders could compare ... track genes related to craving as shoppers moved about ... secret advantage over his love-struck dates. Frightening? Perhaps. ...
Cached Biology News:WCC Announces Version 6 of its ELISE Smart Search and Match Platform for Employment and Biometric Matching 2Real-time gene monitoring developed 2
(Date:8/29/2014)... (PRWEB) August 29, 2014 Intrinsic ... 13485:2003 certified, GAMP® 5 compliant imaging core lab, ... international Phase II clinical trial to assess a ... Throughout this trial, Intrinsic Imaging will provide comprehensive ... to, protocol and charter development, site qualification, site ...
(Date:8/28/2014)... Best Sanitizers, Inc., the first company ... sanitizer, asks food processors and food handling professionals to ... they’re currently using to Best Sanitizers’ Alpet® E3 ... to fighting cross-contamination and the spread of pathogens in ... are key criteria that make a hand sanitizer most ...
(Date:8/28/2014)... spintronics, an electronic which is not only based ... their spin and the spin-related magnetism. Spin-charge converters ... and vice versa. Recently, the research group of ... at Johannes Gutenberg University Mainz in collaboration with ... for the first time realised a new, efficient ...
(Date:8/28/2014)... , Aug. 28, 2014  Next month, executives from clinical ... key industry events beginning with Patient-Centered Clinical Trials 2014 ... Boston , September 4-5. Patient recruitment experts ... Aaron Fleishman will share insights on the benefits ... variety of tactics – from media to mobile apps – ...
Breaking Biology Technology:Intrinsic Imaging Awarded Phase II Clinical Trial to Assess New Treatment for Non-Hodgkin’s Lymphoma 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 3A new, tunable device for spintronics 2A new, tunable device for spintronics 3BBK Worldwide Leads Sessions at Key September Events 2
... - With its recent acquisition of a facility ... has expanded its distribution capabilities to the west ... services for commercial clients, purchased Craftsman Press West, ... distributed magazines, catalogs, and retail inserts. Craftsman Press ...
... - Recently, as I sat at lunch sending off a ... reflect on how our professional lives continue to evolve dramatically, ... the CEO of a company that is driving the adoption ... with how quickly technological change continues to transform and enhance ...
... and global issues going on right now, it could ... issues in yesterday's critical moments. , ,There are ... responsibilities. They are worth applying to your position in ... your view of things. That's very important in today's ...
Cached Biology Technology:Visions: Rimas Buinevicius, CEO of Sonic Foundry 2Visions: Rimas Buinevicius, CEO of Sonic Foundry 3Business leaders can learn from historical insights 2Business leaders can learn from historical insights 3Business leaders can learn from historical insights 4Business leaders can learn from historical insights 5
Assay Diluent, 10 L...
Assay Diluent Trial Pack, 4 x 100 mL...
HRP Monoclonal-Goat Diluent - 5X Concentrate, 25 mL...
SpectroQuest single beam 1.8nm UV/Vis spectrophotometer; stand-alone unit...
Biology Products: