Navigation Links
A breakthrough in understanding the biology and treatment of ovarian cancer
Date:2/21/2012

Researchers at The Pennsylvania State University College of Medicine, Hershey, Pennsylvania have discovered that the presence and integrity of the opioid growth factor receptor (OGFr), which mediates the inhibitory action of opioid growth factor (OGF) on cell proliferation, is a key to understanding the progression and treatment of human ovarian cancer. Transplantation of human ovarian cancer cells that were molecularly engineered to have a reduced expression of OGFr, into immunocompromised mice resulted in ovarian tumors that grew rapidly. This discovery, reported in the February 2012 issue of Experimental Biology and Medicine, provides fresh new insights into the pathogenesis and therapy of a lethal cancer that is the fifth leading cause of cancer-related mortality among women in the USA, and has a death rate that is unchanged for over 75 years.

The OGF (also-termed [Met5]-enkephalin)-OGFr axis plays a fundamental role in cancer, development, and cellular renewal by regulating cell proliferation. An important question addressed in this study relates to the requirement of this peptide-receptor system for the progression of carcinogenesis. Human ovarian cancer cell lines that were genetically modified to underexpress OGFr grew far more rapidly in tissue culture than control (empty vector/wildtype) cell lines. Moreover, the addition of OGF to cultures of these genetically modified cells did not respond to the inhibitory peptide and change cell number, indicating that the loss of OGFr interfered with the function of the OGF-OGFr axis with respect to regulating cell proliferation. Immunocompromised mice injected with ovarian cancer cells that had a reduction in OGFr displayed tumors much earlier than controls, and these tumors grew faster than controls. Putting this information together with knowledge that the pathway for OGF-OGFr regulation of cell proliferation in ovarian cancer is by way of increasing the cyclin-dependent inhibitory kinas
'/>"/>

Contact: Dr. Ian Zagon
isz1@psu.edu
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Breakthrough optical technology to assess colon cancer risk, accuracy
2. Sandia, SES win Popular Mechanics Breakthrough Innovator Award
3. NC State finds new nanomaterial could be breakthrough for implantable medical devices
4. Adult stem cell breakthrough
5. A scientific breakthrough on the control of the bad cholesterol
6. Fly guy makes memory breakthrough
7. Researchers make breakthrough in the production of double-walled carbon nanotubes
8. Key to future medical breakthroughs is systems biology, say leading European scientists
9. World breakthrough in treating premature babies
10. Mount Sinai Hospital researcher makes stem cell breakthrough
11. Stem cell breakthrough gives new hope to sufferers of muscle-wasting diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2015)... 2015  higi, a leading cloud-based consumer engagement platform ... engage with their communities around health and wellness, announced ... secure API.  ... affordable, and convenient vehicle to receive validated health information ... The API will allow higi,s trusted partners, on ...
(Date:4/2/2015)... HAMBURG, Germany , April 2, 2015 /PRNewswire/ ... ten fingerprint tests DERMALOG by far outperforms the ... While always maintaining high accuracy, the system is ... second. Hence, the speed proves up to be ... 40% faster than its runner-up performance. ...
(Date:4/1/2015)... 1, 2015   Medisafe ™, the leading global ... iOS and Android smartphones and ... into the platform to allow patients to track and ... first time, patients will be able to visualize in ... important biometrics, such as glucose levels and blood pressure. ...
Breaking Biology News(10 mins):higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2
... weapon in the arsenal against cancer: Nanoparticles that identify, ... cells alone. Led by Carl Batt, the Liberty ... nanoparticles shaped something like a dumbbell made ... They then attached antibodies, which target a molecule found ...
... of God and the nature of religion, two distinguished ... in evolutionary biology with a focus on brain science, ... Tiger and pioneering neuroscientist Michael McGuire elucidate perennial questions ... arise? What is its source? And why does every ...
... breakthrough treatments for the most common cancers could soon come ... At the ESMO Conference on Sarcoma and GIST, to ... 2010, researchers and some of the world,s leading experts will ... found in muscle, blood vessels, deep skin tissues, nerves and ...
Cached Biology News:Like little golden assassins, 'smart' nanoparticles identify, target and kill cancer cells 2Which came first: Religion or the brain? 2Spotlight on rare tumors in hunt for new cancer treatments 2
(Date:4/21/2015)... April 21, 2015 The North American chromatography systems ... from 2014 to 2019. Based on geography, this market has ... and Mexico . The U.S. accounted for ... . The major factors driving the growth of chromatography systems ... industries are the prime users of chromatography techniques. ...
(Date:4/21/2015)... WORTH, Texas , April 21, 2015 ... to grow from $313.0 million in 2014 to $605.1 million ... period under consideration. Browse through the TOC ... for an in-depth analysis of the industry trends and ... http://www.micromarketmonitor.com/market/north-america-bio-stimulants-6850160039.html Early buyers ...
(Date:4/21/2015)... , April 21, 2015  Scientists from the ... research organization, published a paper today outlining new ... microalgae called diatoms. The researchers, led by first ... author Philip Weyman , Ph.D., conclude that ... understanding of diatom genetics and thus facilitate advances ...
(Date:4/21/2015)... Invetech , a global leader ... contract manufacturing, and  NanoCellect Biomedical, a company ... sorting technology for life science researchers, today announced ... platform. Headquartered in San ... microchip-based cell sorting technology. NanoCellect,s flow cytometry platform ...
Breaking Biology Technology:North American Chromatography systems Market by Types, & by End-Users - Forecast to 2019 2North American Chromatography systems Market by Types, & by End-Users - Forecast to 2019 3North America Biostimulants Market is Expected to Reach $605.1 Million by 2019, at a CAGR of 14.1% From 2014 to 2019 2North America Biostimulants Market is Expected to Reach $605.1 Million by 2019, at a CAGR of 14.1% From 2014 to 2019 3Scientists at the J. Craig Venter Institute Publish Paper Outlining Efficient Synthetic Biology Methods to Genetically Engineer Microalgae 2Scientists at the J. Craig Venter Institute Publish Paper Outlining Efficient Synthetic Biology Methods to Genetically Engineer Microalgae 3NanoCellect And Invetech Announce Collaboration To Develop Novel Flow Cytometry Platform For Cell Sorting And Analysis 2NanoCellect And Invetech Announce Collaboration To Develop Novel Flow Cytometry Platform For Cell Sorting And Analysis 3
... New York on Monday, September 10th, SAN ... biopharmaceutical company developing patient-specific, active,immunotherapies for the treatment ... President and Chief Executive Officer, will present at,the ... p.m. Eastern,time on Monday, September 10, 2007. The ...
... CDC to Ensure US,s Preparedness ... Emergency, CAMBRIDGE, England and CAMBRIDGE, Massachusetts, September ... company, announced today that the US Food and ... Vaccine, Live) vaccine,for protection against smallpox. The vaccine ...
... announced,today that one year findings from the ... net clinical benefit for patients with acute,ST-segment ... Heparin (UFH). The ExTRACT-TIMI 25 and ... sessions at the European Society of Cardiology ...
Cached Biology Technology:FDA Approves ACAM2000(TM) Vaccine for Protection Against Smallpox 2FDA Approves ACAM2000(TM) Vaccine for Protection Against Smallpox 3FDA Approves ACAM2000(TM) Vaccine for Protection Against Smallpox 4FDA Approves ACAM2000(TM) Vaccine for Protection Against Smallpox 5New Study Findings Confirm CLEXANE(R)/LOVENOX(R) Long-Term Clinical Benefit in Patients Suffering From Acute Coronary Syndrome 2New Study Findings Confirm CLEXANE(R)/LOVENOX(R) Long-Term Clinical Benefit in Patients Suffering From Acute Coronary Syndrome 3New Study Findings Confirm CLEXANE(R)/LOVENOX(R) Long-Term Clinical Benefit in Patients Suffering From Acute Coronary Syndrome 4New Study Findings Confirm CLEXANE(R)/LOVENOX(R) Long-Term Clinical Benefit in Patients Suffering From Acute Coronary Syndrome 5
EoProbe Eosinophil Staining Kit, 1 Kit...
B.D. Hames and D.M. Glover (1996) • This issue covers T-Cell antigen receptor genes; T-Lymphocyte signal transduction; B-Cell activation antibody engineering and the complement system and other ...
...
LabFax: Immunochemistry...
Biology Products: