Navigation Links
A boost for cellular profiling
Date:9/22/2013

. This will permit researchers to conduct a more granular analysis of how subtle differences between the same genes in different people -- known as single nucleotide polymorphisms (or SNPs) -- contribute to differences in biology and disease.

The new method is likely to be of great value to cancer research. Identifying rare sub-populations of cells in tumors and understanding their role in the survival and progression of cancers can provide invaluable information for the development of diagnostics and targeted therapies. A study recently published by Ludwig researchers described, for example, how certain subpopulations of cells in melanomas can be pushed into a drug-susceptible state and then destroyed by chemotherapy. More such strategies might be devised as researchers get a better handle on the cellular species found in different types of tumors, and the patterns of gene expression that define them.

Because Smart-seq2 relies on off-the-shelf reagents, it costs roughly a twentieth as much as the commercialized kit, which should allow researchers to conduct sophisticated analyses of single cells on a much larger scale. It can also be improved further by the scientific community, since its constituent components and rationale are both open to the public.

Armed with the more effective and affordable Smart-seq2, Sandberg's lab is now moving ahead on projects that require a large-scale, single-cell gene expression analysis. "Now all researchers can do their own single-cell gene expression analysis by buying the components of the process described in this paper and assembling their own kits," says Sandberg.


'/>"/>

Contact: Rachel Steinhardt
rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. New Brain Supplement Focus Boost Launches, Boosting Alertness, Memory and Focus
2. Playing video games can boost brain power
3. Vitamins and minerals can boost energy and enhance mood
4. Immune-boosting colorectal cancer drug shows promise
5. Unexpected discovery of the ways cells move could boost understanding of complex diseases
6. Herbal extract boosts fruit fly lifespan by nearly 25 percent, UCI study finds
7. Improving crop per drop could boost global food security and water sustainability
8. Fast-sinking jellyfish could boost the oceans uptake of carbon dioxide
9. Quit smoking? Vitamin E may give extra boost to heart health
10. Green spaces may boost well-being for city slickers
11. Vaccine adjuvant uses host DNA to boost pathogen recognition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2015)... Aug. 18, 2015  Navitas today announced ... to the Submission Content Management webinar scheduled ... non-profit forum. Dedicated to the Implementation of Regulatory ... platform for industry, vendors, health authorities, consultants ... work towards a standard method of implementing ...
(Date:8/12/2015)... , Aug. 12, 2015   MedNet Solutions , ... entire spectrum of clinical research, is proud to announce ... company,s comprehensive SaaS-based eClinical technology platform, has led the ... first two quarters of 2015.   Q2 2015 and ... quarters measured by contract value sold in the company,s ...
(Date:8/12/2015)... 12, 2015  Synaptics Inc. (NASDAQ: SYNA ... today announced that four of its fingerprint ID ... officially been named FIDO Certified™ by the Fast ... certification, Synaptics, Natural ID™ fingerprint solutions are fully ... (UAF) standard and are interoperable among other products ...
Breaking Biology News(10 mins):Navitas, a Key Contributor in IRISS Forum Webinar 2Navitas, a Key Contributor in IRISS Forum Webinar 3MedNet Solutions Experiences Explosive Corporate Growth 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 3
... the economic, technological and demographic developments in the globalised world ... and communities in aquatic systems adapt to global change, and ... and the ways in which they serve human beings? What ... volumes of data that now flood every section of society? ...
... Tecnalia has calculated the carbon footprint of the Grupo Faustino,s ... work right up to the end of the bottle,s useful ... information that allows one to know the quantity of greenhouse ... Grupo Faustino to be the first winery to find out ...
... so called P/Q-type channel, in neurons of the cerebellum is ... special type of epilepsy. This is reported by the research ... from the Ruhr-Universitt Bochum. They investigated mice that lacked the ... of the cerebellum. "We expect that our results will contribute ...
Cached Biology News:DFG establishes 13 new priority programs 2DFG establishes 13 new priority programs 3DFG establishes 13 new priority programs 4Tecnalia has calculated the carbon footprint of some wines 2Dysfunction in cerebellar Calcium channel causes motor disorders and epilepsy 2
(Date:8/28/2015)... ... August 28, 2015 , ... Pittcon is pleased to ... a session on chemical spectroscopic imaging at JASIS 2015 (Japan Analytical & Scientific ... analytical and scientific instruments show which will be held at International Conference Hall ...
(Date:8/27/2015)... ... August 27, 2015 , ... Capital Edge Consulting , a nationwide ... pleased to announce their ranking as one of the top 5000 companies listed on ... companies across the nation. , “It is truly an honor to be recognized as ...
(Date:8/27/2015)... , Aug. 27, 2015 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" ... six-month periods ended June 30, 2015. Biorem,s complete second quarter financial ... FINANCIAL HIGHLIGHTS: in ,000,s except earnings per shareThree-months ended , ... 2014 , 2015 , 2014 Revenue , ... , 4,433 Gross profit , 1,656 , ...
(Date:8/27/2015)... TRIANGLE PARK, N.C. , Aug. 27, 2015 ... on the decision by FedEx, UPS and The ... of certain biological specimens classified as ,select agents, ... and long history of handling these sensitive shipments. ... knowledge of global transportation regulations, trained and certified ...
Breaking Biology Technology:U.S. Symposium on Imaging Organized by Pittcon’s Program Chairman Chuck Gardner 2U.S. Symposium on Imaging Organized by Pittcon’s Program Chairman Chuck Gardner 3Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 2Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 3BIOREM Reports $718,000 Net Earnings for the Second Quarter 2BIOREM Reports $718,000 Net Earnings for the Second Quarter 3Marken Ensures Safe Transportation Of Select Agents And Toxins 2
... LightSpeed VCT, the world's first volume computed tomography ... Wall Street Journal in the Medical Device ... The annual awards recognize technological breakthroughs by individuals, ... wide range of areas, including medicine. , ...
... has already been invented. I've been known to crawl ... 15 years about technology innovation, and then the next ... From a quick look into the industry buzz, it ... getting crowded. Pick up any industry publication and you're ...
... federal Food and Drug Association today approved GE ... system designed to help doctors detect, diagnose and monitor ... mass and increased risk of fracture, more accurately and ... clinicians to simultaneously assess body composition and ascertain fat ...
Cached Biology Technology:The end of technology history 2The end of technology history 3