Navigation Links
A bio patch that can regrow bone
Date:11/7/2013

Researchers at the University of Iowa have created a bio patch to regenerate missing or damaged bone by putting DNA into a nano-sized particle that delivers bone-producing instructions directly into cells.

The bone-regeneration kit relies on a collagen platform seeded with particles containing the genes needed for producing bone. In experiments, the gene-encoding bio patch successfully regrew bone fully enough to cover skull wounds in test animals. It also stimulated new growth in human bone marrow stromal cells in lab experiments.

The study is novel in that the researchers directly delivered bone-producing instructions (using piece of DNA that encodes for a platelet-derived growth factor called PDGF-B) to existing bone cells in vivo, allowing those cells to produce the proteins that led to more bone production. Previous attempts had relied on repeated applications from the outside, which is costly, intensive, and harder to replicate consistently.

"We delivered the DNA to the cells, so that the cells produce the protein and that's how the protein is generated to enhance bone regeneration," explains Aliasger Salem, professor in the College of Pharmacy and a co-corresponding author on the paper, published in the journal Biomaterials. "If you deliver just the protein, you have keep delivering it with continuous injections to maintain the dose. With our method, you get local, sustained expression over a prolonged period of time without having to give continued doses of protein."

The researchers believe the patch has several potential uses in dentistry. For instance, it could be used to rebuild bone in the gum area that serves as the concrete-like foundation for dental implants. That prospect would be a "life-changing experience" for patients who need implants and don't have enough bone in the surrounding area, says Satheesh Elangovan, assistant professor in the UI's College of Dentistry and a joint first author, as well as
'/>"/>

Contact: Richard Lewis
richard-c-lewis@uiowa.edu
319-384-0012
University of Iowa
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. New method generates cardiac muscle patches from stem cells
2. Small patches of native plants help boost pollination services in large farms
3. Rice, Texas Childrens team creates biocompatible patch to heal infants with birth defects
4. Ultrasound patch heals venous ulcers in human trial
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A bio patch that can regrow bone
(Date:9/17/2014)... EAST LANSING, Mich. Mutations in the human retinoblastoma ... Now, Michigan State University scientists have turned to fruit ... cancer gene. , In a paper featured on ... Journal of Biological Chemistry , Michigan State University researchers ... mutations similar to those present in the human cancer ...
(Date:9/17/2014)... R.I. [Brown University] After decades of decline, grasses ... saltmarshes. To the eye, the marsh in those places ... that a key service of the marsh coastal ... back but the ecosystem function hasn,t come back," said ... senior author of the study in the journal ...
(Date:9/17/2014)... great deal about complex social behavior by studying nonhuman ... teach too. , With their unusually large brains relative ... in a complex social environment---not merely in a large ... but in a dynamic setting of alliances and competitors. ... dolphins, whales, primates, and social carnivores, like hyenas and ...
Breaking Biology News(10 mins):Abnormal properties of cancer protein revealed in fly eyes 2Cape Cod saltmarsh recovery looks good, falls short 2Cape Cod saltmarsh recovery looks good, falls short 3Being social: Learning from the behavior of birds 2
... HOUSTON -- (May 28, 2010) -- A team ... critical effects at the heart of the latest high-temperature ... it. In new research appearing online today in ... University-led team offers new evidence about the quantum features ...
... 27, 2010 Ardipithecus ramidus a purported ... the Year" is coming under fire from scientists who ... there were dense woodlands at the African site where the ... abundant evidence for open savanna habitats," says University of Utah ...
... carry pumps that expel antibiotics, making the bugs hard ... pumps could be the bugs, Achilles heel. ... molecular pumps in Listeria bacteria, and perhaps in other ... strong immune response in the cells they infect. A ...
Cached Biology News:Zeroing in on quantum effects 2Zeroing in on quantum effects 3Out of the woods for 'Ardi' 2Out of the woods for 'Ardi' 3Out of the woods for 'Ardi' 4New bacterial signaling molecule could lead to improved vaccines 2New bacterial signaling molecule could lead to improved vaccines 3
(Date:9/16/2014)... Washington, USA (PRWEB) September 16, 2014 ... to create the features that we desire in optical ... Center at Montana State University. “As we explore surfaces ... Some of those lessons were presented in San Diego ... of Light: Light in Nature ” chaired by Shaw ...
(Date:9/16/2014)... that can harvest energy from jaw movements has been ... It is hoped that the device can generate electricity ... of small-scale implantable or wearable electronic devices, such as ... devices. , The first results of the device,s performance ... journal Smart Materials and Structures . , Jaw ...
(Date:9/16/2014)... emerging field of molecular electronics could take our ... the construction of tiny circuits from molecular components. ... take on the roles currently played by comparatively-bulky ... researchers from five Japanese and Taiwanese universities has ... electronics: a molecule called picene. In a paper ...
(Date:9/16/2014)... who created a deicing film for radar domes have ... coating for glass. , The new work by ... glass surfaces from windshields to skyscrapers free of ice ... (RF). , The technology was introduced this month ... and Interfaces . , The material is made ...
Breaking Biology Technology:Nature’s designs inspire research into new light-based technologies 2Nature’s designs inspire research into new light-based technologies 3Nature’s designs inspire research into new light-based technologies 4Nature’s designs inspire research into new light-based technologies 5'Smart material' chin strap harvests energy from chewing 2The future face of molecular electronics 2Nanoribbon film keeps glass ice-free 2
... a maker of cardiology information and imaging systems, has ... Alabama, for $40 million in cash. , ,Emageon makes ... each company an entre into the other's market, said ... Madison and an Emageon board member. , ,Camtronics ...
... Madison, Wis. After Gov. Jim Doyle vetoed a ... cells for research purposes, the legislative director of Wisconsins Right ... of a science fiction movie. , ,We're not talking about ... . . not for stem cells but for organs and ...
... as Wal-Mart proliferates the American landscape, Google ... A day does not go by that Google's brand and ... reader of news media, and business owner. , ,The ... selling ads, went public just 15 months ago at $85 ...
Cached Biology Technology:Camtronics Medical Systems is bought by Alabama company 2Separating science fiction from reality in the human cloning debate 2Separating science fiction from reality in the human cloning debate 3Are you a citizen of the "Google Nation?" 2Are you a citizen of the "Google Nation?" 3
RAT ANTI MOUSE F4/80 ANTIGEN:BIOTIN Immunogen: Thioglycollate stimulated peritoneal macrophages from C57/BL mice...
SHEEP ANTI FLECAINIDE...
ANTI PIG LDH H4...
RAT ANTI MOUSE F4/80 ANTIGEN:BIOTIN Immunogen: Thioglycollate stimulated peritoneal macrophages from C57/BL mice...
Biology Products: