Navigation Links
A bio patch that can regrow bone
Date:11/7/2013

Researchers at the University of Iowa have created a bio patch to regenerate missing or damaged bone by putting DNA into a nano-sized particle that delivers bone-producing instructions directly into cells.

The bone-regeneration kit relies on a collagen platform seeded with particles containing the genes needed for producing bone. In experiments, the gene-encoding bio patch successfully regrew bone fully enough to cover skull wounds in test animals. It also stimulated new growth in human bone marrow stromal cells in lab experiments.

The study is novel in that the researchers directly delivered bone-producing instructions (using piece of DNA that encodes for a platelet-derived growth factor called PDGF-B) to existing bone cells in vivo, allowing those cells to produce the proteins that led to more bone production. Previous attempts had relied on repeated applications from the outside, which is costly, intensive, and harder to replicate consistently.

"We delivered the DNA to the cells, so that the cells produce the protein and that's how the protein is generated to enhance bone regeneration," explains Aliasger Salem, professor in the College of Pharmacy and a co-corresponding author on the paper, published in the journal Biomaterials. "If you deliver just the protein, you have keep delivering it with continuous injections to maintain the dose. With our method, you get local, sustained expression over a prolonged period of time without having to give continued doses of protein."

The researchers believe the patch has several potential uses in dentistry. For instance, it could be used to rebuild bone in the gum area that serves as the concrete-like foundation for dental implants. That prospect would be a "life-changing experience" for patients who need implants and don't have enough bone in the surrounding area, says Satheesh Elangovan, assistant professor in the UI's College of Dentistry and a joint first author, as well as
'/>"/>

Contact: Richard Lewis
richard-c-lewis@uiowa.edu
319-384-0012
University of Iowa
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. New method generates cardiac muscle patches from stem cells
2. Small patches of native plants help boost pollination services in large farms
3. Rice, Texas Childrens team creates biocompatible patch to heal infants with birth defects
4. Ultrasound patch heals venous ulcers in human trial
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A bio patch that can regrow bone
(Date:3/24/2015)... March 24, 2015   Crossmatch ™, a ... announced that its U.are.U ® 4500 Fingerprint ... Goorin Bros . to achieve PCI compliance for ... access to the POS terminal, protecting the retailer ... data breaches. With one-third of ...
(Date:3/23/2015)... 2015  In the 2014 fiscal year, irs.gov recorded ... This figure accounts for a fraction of the estimated ... Report, exceeds $11 billion globally. The polygraph has traditionally ... has occurred. Investor Mark Saint Juste along ... Paolella partnered to administer the test in a ...
(Date:3/20/2015)... , Mar. 19, 2015 Research and Markets ... "Hand Geometry - Global Strategic Business Report" report ... markets for Hand Geometry in US$ Thousands. The report provides ... , Japan , Europe ... , and Rest of World. Annual estimates ...
Breaking Biology News(10 mins):Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4
... 25, 2008, approaching 5 p.m. PDT, NASA scientists will be ... at that time the Phoenix Mars Mission space vehicle will ... soft landing onto the northern Mars terrain called Green Valley. ... Red Planet. The place got its name after analysis of ...
... Angeles, London, New Delhi, and Singapore (April 14, 2008) ... consumption is not related to overweight in children, according ... Between 100% Fruit Juice Consumption and Weight in Children ... Journal of Lifestyle Medicine (AJLM), published by SAGE. ...
... cycle plays a major role in seagrass fields. ... of seagrasses in Indonesia. He discovered that the ... an efficient nitrogen cycle in tropical seagrass fields. ... retained. Seagrass fields are coastal ecosystems ...
Cached Biology News:Phoenix mission to Mars will search for climate clues 2Phoenix mission to Mars will search for climate clues 3New research: Fruit juice consumption not related to overweight in children 2Nitrogen retained through loss 2
(Date:4/16/2015)...  In recognition of World Hemophilia Day, Biogen  (NASDAQ: ... illuminate more than 15 prominent landmarks red throughout ... Zakim Bridge and Prudential Tower, Chicago,s ... Superdome and Denver,s Coors Field ... 17, and coincide with hemophilia community events in a dozen ...
(Date:4/16/2015)... April 16, 2015 ... pharmaceutical investment and R&D group, and Lancet, ... research, development and commercialization of new medicines ... the intention to stimulate the innovative development ...      (Logo: http://photos.prnewswire.com/prnh/20150416/739742-a) ,     (Logo: http://photos.prnewswire.com/prnh/20150416/739742-b) , ...
(Date:4/16/2015)... 2015 Avelas Biosciences, an in vivo ... announced today that it has initiated a Phase 1b ... women with primary, non-recurrent breast cancer undergoing surgery. In ... addition of Steven Chen , M.D., as vice ... dose escalation study will enroll up to 39 women ...
(Date:4/16/2015)... Fairleigh Dickinson University ( FDU ) ... the Executive Director of the Rothman Institute of ... of the Initiative for Patient Centered Innovation (iPCI), ... the Rothman Institute of Innovation and Entrepreneurship (within ... with FDU’s School of Pharmacy’s Center for Healthcare ...
Breaking Biology Technology:Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 2Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 3Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 4Lancet and ChemRar High Tech Center Have Announced a Partnership in the Development and Production of Novel Drugs in Russia 2Avelas Biosciences Initiates Phase 1b Trial of AVB-620 in Breast Cancer Patients 2Avelas Biosciences Initiates Phase 1b Trial of AVB-620 in Breast Cancer Patients 3Dr. Joseph V. Gulfo Named Executive Director of Fairleigh Dickinson University’s Rothman Institute to Spearhead New Initiative for Patient-Centered Innovation (iPCI) 2Dr. Joseph V. Gulfo Named Executive Director of Fairleigh Dickinson University’s Rothman Institute to Spearhead New Initiative for Patient-Centered Innovation (iPCI) 3
... ... San Diego, CA (PRWEB) December 3, ... based on the products of newborn fibroblasts, announced today that ... Officer. Gollamudi,s business and product development expertise will be invaluable ...
... Iceland, Dec. 3 ,HemoGenix(R) and ORF Genetics announce ... and cytokines for use in all HALO(R),Assay Kits ... of human,blood-forming cells is detected. , ... large number of growth factors and cytokines using,barley ...
... Rigel,Pharmaceuticals, Inc. (Nasdaq: RIGL ) today announced ... call with simultaneous webcast,on Sunday, December 7, 2008, at 4:00 ... trial of R788, an oral Syk kinase inhibitor, in,patients with ... Conference Call and Webcast Information , ...
Cached Biology Technology:Histogen Welcomes Dr. Hyma Gollamudi as Chief Business Officer 2HemoGenix(R), Inc Announces Implementation of ORF Genetics Human Growth Factors and Cytokines in All Human HALO(R) Assay Kits and Contract Research Services 2HemoGenix(R), Inc Announces Implementation of ORF Genetics Human Growth Factors and Cytokines in All Human HALO(R) Assay Kits and Contract Research Services 3Rigel to Host Conference Call to Discuss Phase 2 Study Results of R788 in Lymphoma Presented at ASH 2
RAT ANTI MOUSE TCR V BETA 7:RPE Immunogen: T-cell lymphoma TK1...
ANTI S. ENT TOX BC2D...
... Anti-Major DNA-binding protein(DBP). Protein size: ... NP_001343 ELISA titre using peptide ... conditions for Western Blot: 1.0g/ml ... and HRP conjugated anti-Rabbit IgG should be ...
Collected from sexually mature, mixed sex, mixed breed guinea pigs. Pricing: $120/unit for 1 - 10 units...
Biology Products: