Navigation Links
A*Star scientists discover how to combat hospital-acquired infections and life-threatening toxins
Date:7/22/2011

ads to US$45 billion in healthcare cost annually and results in nearly 100,000 deaths per year, making HAIs the fourth leading cause of death. The bacteria Pseudomonas aeruginosa that secretes PE toxin is a common cause of HAIs in vulnerable individuals, including those with burn injuries or receiving intensive care. Unfortunately, HAIs are increasingly difficult to treat because the emergence of antibiotic-resistant bacteria is on the rise. Similarly, the E. coli strain that produces Shiga toxins, found in the recent deadly food poisoning cases in Germany, were also resistant to antibiotics. Moreover, in food poisoning cases caused by such toxin-producing bacteria, doctors refrain from using antibiotics as killing the bacteria actually causes more toxins to be released, bringing on the worst symptoms of the illness . There is therefore a real need worldwide for antidotes against these life-endangering toxins.

Highlighting the significance of this study, Dr Bard added, "Through this genome-wide screen, our understanding of how toxins interact with human cells at the molecular level expanded tremendously. Our hope is that with these new therapeutic targets identified from the human genome, we will be one step closer to finding toxin antidotes that will make hospital-acquired infections and enterotoxic E. Coli outbreaks a thing of the past."

More about protein toxins

Though immunologically different from each other, Ricin, PE, Diphtheria and Shiga toxins all kill by destroying the cell's protein synthesis 'factories', the place where all proteins necessary for the cell's survival are produced. To travel to these protein 'factories' in the cell, the toxins first trick the host cell into turning off a natural defense mechanism that destroys foreign proteins. Next, they exploit the host cell's internal transport pathway to reach the protein 'factories', destroying them and killing the cell. When this happens, cell death is imminent.
'/>"/>

Contact: Dr. Sarah Chang KC
chang_kai_chen@a-star.edu.sg
656-826-6442
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Agilent Technologies and A*STAR launch all-in-one drug screening platform
2. A*STAR scientists score hat-trick against cancer
3. UCLA scientists complete first mapping of molecule found in human embryonic stem cells
4. Cutting-edge imaging techniques for neuroscientists available in latest laboratory manual
5. New duck-billed dinosaur gives scientists clues to evolution of head ornamentation and provinciality
6. Scripps Research scientists create vaccine against heroin high
7. Hebrew U. scientists show for first time how early human embryo acquires its shape
8. Plenary speakers address challenges in the delivery of sustained antiretroviral therapy in developing countries, call for social scientists to take their place at the HIV/AIDS policy-making table, and stress the need for a long-term response to AIDS
9. OHSU scientists discover new role for vitamin C in the eye -- and the brain
10. Scientists to assemble knowledgebase on plants, microbes, to aid US biofuel, environment efforts
11. Simple little spud helps scientists crack potatos mighty genome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... many times it,s demonstrated, it,s still hard to ... But by using a signaling system called "quorum ... to suit their population. In short, some bacteria ... act accordingly. , Once the population of quorum-sensing ... innocuous to pathogenic, or from unhelpful to helpful. ...
(Date:9/18/2014)... Sept. 18, 2014 -- Arizona turned its newborn screening ... a few short months, earning it the first-ever Newborn Screening ... March of Dimes presented Will Humble, M.P.H., Arizona,s Department of ... here today. Mr. Humble established a policy of full transparency ... send newborn blood samples to the lab for analysis, and ...
(Date:9/18/2014)... comprise all spheres of our planet. Manifold interactions ... and perturbations that resulted in increases of the ... climate changes which influence the complex biogeochemical processes ... these feedback mechanisms has become an important new ... past three decades. , In parallel, a novel ...
Breaking Biology News(10 mins):Researchers study vital 'on/off switches' that control when bacteria turn deadly 2Researchers study vital 'on/off switches' that control when bacteria turn deadly 3March of Dimes honors Arizona with first-ever newborn screening award 2March of Dimes honors Arizona with first-ever newborn screening award 3Greenhouse gas research enters a new era 2
... and the University of Sheffield have applied computing power to crack ... a partial answer to the age old question "what came first ... in this context is "chicken" or at least a particular ... particular chicken protein turns out to come both first and last. ...
... 2010) -- The Damon Runyon Cancer Research Foundation, ... career researchers and innovative cancer research, named 18 ... Award Committee review. The recipients of this ... basic and translational cancer research in the laboratories ...
... A North Carolina State University entomologist has for the ... termite queens to prevent other termites in the colony from ... In a study published online this week in ... Dr. Ed Vargo and colleagues from Japan and Switzerland show ...
Cached Biology News:Researchers apply computing power to crack egg shell problem 2Damon Runyon Cancer Research Foundation awards prestigious fellowships to 18 top young scientists 2Damon Runyon Cancer Research Foundation awards prestigious fellowships to 18 top young scientists 3Damon Runyon Cancer Research Foundation awards prestigious fellowships to 18 top young scientists 4Damon Runyon Cancer Research Foundation awards prestigious fellowships to 18 top young scientists 5Damon Runyon Cancer Research Foundation awards prestigious fellowships to 18 top young scientists 6Don't let your termites grow up to be mommies 2
(Date:9/19/2014)... 19, 2014 Cereal grain scientists, ... will gather October 5–8, 2014, for the AACC ... Convention Center in Providence, Rhode Island. The comprehensive ... of food scientists, chemists, microbiologists, nutritionists, and those ... production management. To date, 1,000 attendees have registered ...
(Date:9/18/2014)... HealthTronics, Inc ., a ... products and services, announced that a poster related ... versus external beam radiotherapy (EBRT) is being presented ... Association (MAAUA) Annual Meeting in Baltimore, Maryland September ... Cryosurgery and External Beam Radiation as Treatments for ...
(Date:9/18/2014)... September 18, 2014 ... http://www.researchandmarkets.com/research/czvg3s/biocompatible ) has announced the addition ... Global Strategic Business Report" report ... ,This report analyzes the worldwide markets ... by the following Product Segments: Polymeric ...
(Date:9/18/2014)... -- Research and Markets has announced the ... 2014" report to their offering. ... professional and in-depth study on the current state of ... provides a basic overview of the industry including definitions, ... market analysis is provided for the international markets including ...
Breaking Biology Technology:Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 2Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 3HealthTronics Announces Data Comparing Cryotherapy Versus Radiation for Treating Prostate Cancer Poster Presented at the American Urological Association Regional Meeting 2Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3Global Human Albumin Industry Report 2014 2Global Human Albumin Industry Report 2014 3
... Reportlinker.com announces that a new market research ... Propylene Oxide: 2010 World Market Outlook And ... The report analyzes worldwide markets for Propylene ... America. It provides the most complete and current ...
... Feb. 24, 2011 Palatin Technologies, Inc. (NYSE Amex: ... public offering of 23,000,000 units, consisting of 23,000,000 shares of ... of its common stock and Series B Warrants to purchase ... the public of $1.00 per unit. Palatin expects that the ...
... Quest Diagnostics Incorporated (NYSE: DGX ), ... services, announced today that it has signed a definitive ... in genetic testing for neurological disorders, from Thermo Fisher ... in cash.   Athena Diagnostics is the ...
Cached Biology Technology:Reportlinker Adds Propylene Oxide: 2010 World Market Outlook and Forecast 2Palatin Technologies, Inc. Announces Pricing of Public Offering of Common Stock and Warrants 2Palatin Technologies, Inc. Announces Pricing of Public Offering of Common Stock and Warrants 3Quest Diagnostics to Acquire Athena Diagnostics, Establishing Leading Position in Rapidly Growing Neurology Testing Market 2Quest Diagnostics to Acquire Athena Diagnostics, Establishing Leading Position in Rapidly Growing Neurology Testing Market 3Quest Diagnostics to Acquire Athena Diagnostics, Establishing Leading Position in Rapidly Growing Neurology Testing Market 4
... fast and reliable automation for today's ... development laboratories. Staccato Mini-Workstations offer the ... basic liquid handling and material management ... either Caliper's time proven CLARA™ assay ...
Experion StdSens chips are the microfluidic chips used to perform standard-sensitivity RNA analysis (nanogram levels) with the Experion automated electrophoresis system. Each chip has the capacity to...
... in the submicron range are part of ... and control of particle size is important ... can reliably detect the component populations in ... Particle Size Analyzer uses Photon Correlation Spectroscopy ...
...
Biology Products: