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A*STAR scientists solve century-old mystery by finding stable haploid strains of Candida albicans
Date:2/1/2013

d organism to be able to observe a change, thus hindering the progress of the study of the virulence and delaying the development of effective treatment of fungal infections. With this discovery of the haploid phase in Candida albicans, however, scientists will now be able to easily target just one copy of the gene to observe a change, allowing for more successful screening and speeding up the discovery of targets for the development of drugs.

Prof Wang, who is a Research Director at IMCB, said, "Our discovery helps to fill a long missing gap in the life cycle of this important pathogen, greatly advancing our understanding of how it generates genetic variations for evolution and adaptation. At the same time, haploid Candida albicans also allows scientists to carry out traditional genetic screens that will certainly accelerate the identification of genes important for infection and drug targets for medical intervention."

Dr Balasubramanian said, "The paper by Wang, Berman and colleagues cuts across multiple fields, including evolutionary biology, genetics, and medical microbiology. The tools the authors have developed will help speed up the analyses of gene function in this important pathogen and might also therefore speed up our efforts to cure Candida infections".


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Contact: Vithya Selvam
vithya_selvam@a-star.edu.sg
656-826-6291
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

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