Navigation Links
A*STAR scientists solve century-old mystery by finding stable haploid strains of Candida albicans
Date:2/1/2013

A*STAR scientists from the Institute of Molecular and Cell Biology (IMCB) have identified what eluded yeast scientists for the past 100 years, by constructing stable haploid strains of Candida albicans, the most prevalent human fungal pathogen. This discovery, jointly made by two teams of scientists led by Prof Wang Yue of IMCB and Prof Judith Berman of the University of Minnesota, will enable scientists to effectively target and treat infections by Candida albicans. The findings, "The 'obligate diploid' Candida albicans forms mating-competent haploids", were published in the online issue of Nature on 30 January 2013.

Candida albicans ranks among the top four microbial pathogens in hospital-acquired infections of the blood, which has a mortality rate of as high as 45%. Currently, the choice of drugs for treating infections by this pathogen is limited, and drug-resistance has emerged worldwide, posing a great challenge to medicine.

Importance of the discovery

Nearly all other fungi have a haploid and a diploid phase in their life cycle, enabling the haploid cells to mate and generate genetic variations. However, up till this recent discovery, yeast scientists the world over had been unable to identify a haploid phase of this fungus.

Commenting on the significance of the discovery, Dr Mohan Balasubramanian, Senior Investigator at Temasek Lifesciences Laboratory and a leading yeast geneticist in the world, said, "The scientists show that the human pathogenic yeast Candida albicans, long thought of as always having two copies of each chromosome and no sexual reproduction in its life, in fact can and does exist as a sexually reproducing cell carrying only one copy of its genome."

Without a haploid phase, it is indeed extremely difficult for scientists to carry out genetic screens in fungi as this would require the precise targeting of both copies of a gene in a diploi
'/>"/>

Contact: Vithya Selvam
vithya_selvam@a-star.edu.sg
656-826-6291
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1 2

Related biology news :

1. Breakthroughs in Chikungunya research from A*STAR spell new hope for better treatment and protection
2. A*STAR scientists discover potential drug for deadly brain cancer
3. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
4. Queens scientists seek vaccine for Pseudomonas infection
5. Scientists produce eye structures from human blood-derived stem cells
6. American Society of Plant Biologists honors early career women scientists
7. Brandeis scientists win prestigious prize for circadian rhythms research
8. Scientists discover new method of proton transfer
9. Salk scientists open new window into how cancers override cellular growth controls
10. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
11. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... in homes could pose a significant health risk to people ... Journal of Allergy and Clinical Immunology . , By ... countries, the research has found that the presence of several ... sufferers, as well as increasing the likelihood of developing the ... at the University of Exeter Medical School and is the ...
(Date:8/28/2014)... have assigned a number of 435-million-year-old fossils to ... lived in shallow marine habitats and were far ... strata. , Before they sank to the ... fossilized some 435 million years ago, these arthropods ... although they were not exactly inconspicuous, possessing ...
(Date:8/27/2014)... short-faced bears, giant ground sloths, saber-toothed cats and American ... ago at the end of the Pleistocene period. The ... by scientists who, until recently, could only speculate as ... Santa Barbara,s James Kennett, professor emeritus in the Department ... Earth played a major role in the extinction. Their ...
Breaking Biology News(10 mins):Indoor mold poses health risk to asthma sufferers 2Paleontology: Oldest representative of a weird arthropod group 2Nanodiamonds are forever 2Nanodiamonds are forever 3
... for all sorts of biological molecules and traits. But University ... shape metallic structures. The team found that DNA segments ... crystals that have many applications in medicine, electronics and catalysis. ... the U. of I., the team published its surprising findings ...
... -- For much of the year drought has been plaguing ... not appear to be losing the turf war against climate ... Kansas State University-led study looked at the drought tolerance of ... was to better understand how grasslands in different parts of ...
... large and growing problem throughout the developed world, and ... the recalcitrant bacteria. When bacteria aggregate into so-called biofilm, ... only been able to speculate about what happens when ... In close collaboration between various specialist fields, ...
Cached Biology News:Oh, my stars and hexagons! DNA code shapes gold nanoparticles 2Diversity keeps grasslands resilient to drought, climate change 2Diversity keeps grasslands resilient to drought, climate change 3New scientific method unmasks chronic infections 2
(Date:8/28/2014)... Scientists, researchers, and technologists will converge in ... 2014 symposium. Marking its 46th year, the annual ... 14-17 September. The event is sponsored by SPIE, ... The premier conference for basic and applied issues which ... will engage researchers and engineers from numerous industries and ...
(Date:8/28/2014)... August 28, 2014 Supplementing their ... a promotion for Eppendorf Safe Lock Centrifuge ... purchase the highest quality tubes at an affordable ... for customers doing chemical, medical, pharmaceutical, and life ... are not regularly able to afford Eppendorf products. ...
(Date:8/27/2014)... Rhythm, a biopharmaceutical company developing peptide therapeutics that address ... disorders, announced today that it has filed a registration ... Exchange Commission (SEC) relating to the proposed initial public ... of shares to be offered and the price range ... Citigroup and Cowen and Company will act as ...
(Date:8/27/2014)... is how plants survive impact by the huge ... while using this energy for photosynthesis. The hypothesis ... blades quickly dissipate the energy throughout the entire ... DTU Physics have now managed to successfully ,film, ... contain light-absorbing proteins which play a role in ...
Breaking Biology Technology:Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 3Rhythm Files Registration Statement for Proposed Initial Public Offering 2DTU researchers film protein quake for the first time 2
... the temptation to set forth predictions for 2007 is just too ... five predictions for the next 12 months if you'll send me ... - foresights? - to chris@guidewiregroup.com before the end of ... Web 2.0 goes away , ,Well, not Web 2.0 the ...
... - Mirus Bio Corp. , a Madison-based company engaged in ... a United States patent on a new injection delivery method. , ... effective method to deliver nucleic acids such as RNA for the ... University of Wisconsin-Madison , it has developed a more rapid method ...
... one in five adults holds a four-year college degree. In ... college. Is it any surprise that household incomes in Dane County ... Alliance has provided a fresh look at household incomes in ... advice: Stay in school, earn a degree, and maybe you'll make ...
Cached Biology Technology:Bold prediction: Web 2.0 goes away in 2007 2Bold prediction: Web 2.0 goes away in 2007 3Mirus Bio awarded patent on RNA delivery 2Mirus Bio awarded patent on RNA delivery 3Closing the income gap begins with education 2Closing the income gap begins with education 3Closing the income gap begins with education 4
... NeuroLog System is a compact, versatile & modular ... of purposes including: Intracellular, Extracellular, Transducer & ... The NeuroLog Case & Power Supply unit (NL900D) ... Modules are not only powered by this unit, ...
37-1A9...
Porcine Coronary Artery Endothelial Cells (PCAEC) (>500,000 cells)...
Proliferin (N-14)...
Biology Products: