Navigation Links
A*STAR scientists score 'hat-trick' against cancer
Date:7/13/2010

Scientists from Singapore's Agency of Science, Technology and Research (A*STAR) have made three successive breakthroughs in key areas of cancer research. Their work, published in top scientific journals Cancer Cell, Nature Cell Biology, and Cancer Research, sheds light on the mechanism behind cancer metastasis, suggest why breast cancer cells live as long as they do, and show a better way to detect and fight cervical cancer.

Stopping the spread of cancer

A team of scientists led by Dr Zeng Qi , from A*STAR's Institute of Molecular and Cell Biology (IMCB) has made a discovery about how PRL-3, a protein that plays a key role in tumorigenesis and cancer metastasis, is regulated in the body by PCBP1. Together with her collaborator Dr. Leah Vardy from A*STAR's Institute of Molecular Biology (IMB), the scientists found that PCBP1 impedes the translation of PRL-3 mRNA. Their discovery, published today in the leading journal Cancer Cell, sheds light on the role of PRL-3 in cancer and suggests possible ways to prevent metastasis, arguably the most pernicious and harmful aspect of the disease.

PRL-3 was first identified by Dr Zeng in 1998. However, the mechanism controlling the expression of PRL-3 is poorly understood. While trying to understand how PRL-3 expression is regulated in the body, the scientist discovered that PCBP1 was responsible for suppressing the expression of PRL-3. Using their mouse model, the scientists found that inducing over-expression of PCBP1 significantly reduced tumour size, suggesting that controlling levels of PCBP1 may be a means of suppressing the growth and spread of tumours in the body.

Said Dr Zeng, "The finding of PCBP1 as a potential tumor suppressor is highly significant as a similar mechanism may be regulating other cancer genes. Since PRL-3 plays multiple tasks in contributing to cancer metastasis, we are extremely excited to discover the mechanism underlying PR
'/>"/>

Contact: Joshua Tan
joshua_tan@a-star.edu.sg
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scientists use computer algorithms to develop seasonal flu vaccines
2. Damon Runyon Cancer Research Foundation awards prestigious fellowships to 18 top young scientists
3. PNNL scientists win 4 R&D 100 awards for environment, biology, security technologies
4. Scientists describe 2 new species of fish from area engulfed by oil spill
5. Marine scientists return with rare creatures from the deep
6. Scientists find direct line from development to growth
7. UM School of Medicine scientists develop new strategy that may improve cognition
8. Honey as an antibiotic: Scientists identify a secret ingredient in honey that kills bacteria
9. NOAA-supported scientists predict larger than average Gulf dead zone
10. SAGE to publish the Bulletin of the Atomic Scientists
11. Scientists call on US to stem ecological impact of trade in coral reef wildlife
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2014)... GARDENS, Fla. , Dec. 3, 2014 /PRNewswire/ ... solutions, today announced that its DigitalPersona ® ... fingerprint readers have been deployed throughout First Bank ... , South Carolina and ... in Southern Pines, North Carolina ...
(Date:11/21/2014)... NEW YORK , Nov. 19, 2014  Earlier ... Board at New York College, and one of the ... for biosensor signals that are transmitted from Smartphones to ... there were Smartphones and has one of the earliest ... are discussing its usage in the military, child care, ...
(Date:11/18/2014)... , Nov. 18, 2014  The Secure ... Industry Association today jointly announce the formation of ... release of its Identity and Biometric Entry ... The Framework received official support from BORDERPOL, the ... to improve and provide expertise regarding border security, ...
Breaking Biology News(10 mins):First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3
... 50,000 people have uncovered several DNA sequence variations associated ... The findings, reported in Nature Genetics , may ... mechanisms for abnormal heart rhythms and sudden cardiac death. ... complex," says co-author Glenn I. Fishman, MD, the William ...
... With chitlins about to make their annual appearance on ... news for millions of people who love that delicacy of ... the first identification of an ingredient in cilantro that quashes ... to drive people from the house when chitlins are cooking. ...
... news aggregator that compiles life sciences-focused news stories from an ... daily email digest format, free of charge to subscribers. In ... or tweet their favorite news stories, and even submit news ... direct to their email in-box on any the following topics: ...
Cached Biology News:DNA sequence variations linked to electrical signal conduction in the heart 2Cilantro ingredient can remove foul odor of 'chitlins' 2
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... -- " Ask,Extractor " ... Help Researchers Narrow Search Results,-- ... and services, today announced two new,applications from Molecular Connections, a ... Ask Extractor is an application based on Molecular Connections,XTractor, a ...
... Ga. and CARDIFF, Wales, June 16, 2011 ... custom fermentation, microbial product formulation and antimicrobial product ... Innovation Award in the chemical products category for ... award, which honors creative products, solutions and entrepreneurial ...
... AppTec announced today that it has been selected as one ... by China,s Ministry of Commerce. The list was announced at ... Nanjing on June 10, 2011. Dr. Ge Li, Chairman and ... Ten Contributor to China,s Outsourcing Industry. The conference ...
Cached Biology Technology:Elsevier and Molecular Connections Develop Two New Applications on SciVerse Applications 2Elsevier and Molecular Connections Develop Two New Applications on SciVerse Applications 3Elsevier and Molecular Connections Develop Two New Applications on SciVerse Applications 4Elsevier and Molecular Connections Develop Two New Applications on SciVerse Applications 5Elsevier and Molecular Connections Develop Two New Applications on SciVerse Applications 6Genesis Biosciences Receives Pulire Innovation Award for e card Sanitary Bin Treatment Product 2
Human FADD Affinity Purified Polyclonal Ab...
Human VEGF R3/Flt-4 Phycoerythrin MAb (Clone 54733)...
Immunogen: Synthetic Peptide: V(22) N G H E F E I E G E G E G R(36) Storage: -20 C, Avoid Freeze/Thaw Cycles...
Human beta IG-H3 MAb (Clone 348506) Keywords: BIGH3, betaIG-H3 Protein Family: Extracellular Matrix Molecules...
Biology Products: