Navigation Links
A*STAR scientists' groundbreaking discovery of nucleus structure crucial to understanding diseases
Date:2/8/2013

1. Scientists from Singapore and Germany have identified that the proteins lamin A (Lmna) and lamin B receptor (Lbr) are essential for holding silent genes in their correct position at the edge of the nucleus, in the form of heterochromatin . A deviation from their normal position will cause the genes to malfunction, leading to heart failure, vascular disease and muscle wasting.

2. For hundreds of years before this discovery, scientists were puzzled by why heterochromatin clustered at the edge of the nucleus and how it was relevant to normal cell function. This recent discovery will enable scientists to gain a better understanding of the diseases of the heart and muscles, and find cures for them in the future.

3. The findings by Audrey Wang and Colin Stewart of A*STAR's Institute of Medical Biology and Irina Solovei, Boris Joffe and Heinrich Leonhardt of the Ludwig Maximillian University in Munich, Germany, were recently published in the prestigious journal Cell .

4. The nucleus the brain of the cell carries all the information, in the form of chromatin necessary to help a cell grow, thrive, and reproduce, in the form of DNA packed into chromatin. Hence, understanding how chromatin is organised in the nucleus is important to understanding disease and normal processes such as ageing. The scientists showed that the two proteins lamin A and lamin B receptor are important to the organisation of chromatin in the nucleus. Using mouse models, they demonstrated that in the absence of the two proteins, heterochromatin collapsed into the nuclear centre. This disrupted gene expression and affected skeletal muscle development, resulting in muscle failure (Annex A).

5. Professor Stewart, Research and Assistant Director of IMB, said, "These findings will provide new insights into how diseases arise and may help explain how mutations in lamin proteins result in a variety of different syndromes. In particular, we are extending these findings to explore how changes in chromatin position may contribute to heart failure. Moving forward, we will collaborate with cardiologists and vascular clinicians at SGH and NUHS to translate these findings to benefit patients."

6. Professor Birgitte Lane, Executive Director of IMB, said, "I would like to congratulate Colin and the team for this important piece of research. It brings us a step closer to understanding the nucleus and to developing new treatments for common diseases. It could be particularly relevant for Singapore, as we, like other developed nations, are facing an ageing population, and heart failure, vascular disease and muscle wasting all increase with age."


'/>"/>

Contact: Ong Siok Ming
ong_siok_ming@a-star.edu.sg
656-826-6254
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert  

Related biology news :

1. A*STAR scientists solve century-old mystery by finding stable haploid strains of Candida albicans
2. A*STAR scientists discover potential drug for deadly brain cancer
3. Breakthroughs in Chikungunya research from A*STAR spell new hope for better treatment and protection
4. Scientists identify genetic mechanism that contributed to Irish Famine
5. Scientists turn toxic by-product into biofuel booster
6. Scientists find a key element of lupus, suggesting better drug targets
7. Scientists notch a win in war against antibiotic-resistant bacteria
8. Plant scientists at CSHL demonstrate new means of boosting maize yields
9. Listening to cells: Scientists probe human cells with high-frequency sound
10. Joslin scientists find first human iPSC from patients with maturity onset diabetes of the young
11. Scientists uncover previously unknown mechanism of memory formation
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A*STAR scientists' groundbreaking discovery of nucleus structure crucial to understanding diseases
(Date:2/8/2017)... 2017 The biometrics market has reached ... of organizations, desires to better authenticate or identify ... and challenge questions), biometrics is quickly working its ... market is driven by use cases, though there ... enterprise uses cases, with consumer-facing use cases encompassing ...
(Date:2/6/2017)... , Feb. 6, 2017 According to ... are driving border authorities to continue to embrace ... there are 2143 Automated Border Control (ABC) eGates ... deployed at more than 163 ports of entry ... to 2016 achieving a combined CAGR of 37%. ...
(Date:2/2/2017)... 1, 2017  Central to its deep commitment ... worldwide, The Japan Prize Foundation today announced the ... pushed the envelope in their respective fields of ... scientists are being recognized with the 2017 Japan ... only contribute to the advancement of science and ...
Breaking Biology News(10 mins):
(Date:2/16/2017)... ... ... EIT Digital has launched work to develop a new Smart IOT ... to get under way for the framework, which is designed to reduce the use ... to be transferred eventually to other industries that also require efficient IoT and management ...
(Date:2/16/2017)... , Feb. 16, 2017  MDNA Life ... the development of liquid biopsy tests based on ... into an exclusive license agreement with its first ... proprietary liquid biopsy test for prostate cancer, the ... Korea . This is the first overseas ...
(Date:2/16/2017)... Feb. 16, 2017   Biostage, Inc. (Nasdaq: ... biotechnology company developing bioengineered organ implants to treat cancers ... trachea, announced today the closing on February 15, 2017 ... of common stock and warrants to purchase 20,000,000 shares ... million. The offering was priced at $0.40 per share ...
(Date:2/16/2017)... N.J. , Feb. 16, 2017  Champions Oncology, ... in the development and sale of advanced technology solutions ... oncology drugs, today announced the addition of new cohorts ... These new models will expand Champions, product line ... head and neck cancer, AML, and non-small cell lung ...
Breaking Biology Technology: