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A*STAR scientists first to identify stem cell key to lung regeneration
Date:10/28/2011

"pods" mature to new alveoli which replace the alveoli that were destroyed by the infection, leading to lung regeneration.

"We have harvested these "pods" to provide insight into genes and secreted factors that likely represent key components in tissue regeneration.

These secreted factors might be used as biological drugs (biologics) to enhance regeneration of the lung and airways," said Dr Frank McKeon, Senior Group Leader of the Stem Cell and Developmental Biology at GIS.

The research was jointly led by Dr Frank McKeon from GIS and Dr Wa Xian from IMB in collaboration with scientists at the National University of Singapore (NUS), and clinicians at the Harvard Medical School and the Brigham and Women's Hospital in Boston.

Prof Birgitte Lane, Executive Director of IMB, said, "This groundbreaking work is a fine example of collaborative research, which has brought us new insight into lung epithelial stem cells. This will have breakthrough consequences in many areas." Dr Edison Liu, Executive Director of GIS, added, "We will continue to seek impactful collaborations and build upon this research area where there is a need for novel therapies, which will offer hope for patients suffering from respiratory diseases."


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Contact: Siok Ming Ong
ong_siok_ming@a-star.edu.sg
65-682-66254
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

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