Navigation Links
A*STAR scientists discover protein's role in human memory and learning functions
Date:2/19/2014

1. Scientists at A*STAR's Institute of Molecular and Cell Biology (IMCB) have identified the precise role of the protein, SNX27, in the pathway leading to memory and learning impairment. The study broadens the understanding of the brain's memory function and could be used to explain defects in the cognitive development of those with Down's syndrome. The newly established knowledge could potentially facilitate exploration of strategies to improve memory and learning abilities in Down's syndrome.

2. Down's syndrome is a genetic condition characterized by the presence of an additional copy of chromosome 21. About one in eight hundred new-borns is diagnosed with Down's syndrome. It is a condition that leads to impairments in both cognitive ability and physical growth that range from mild to moderate developmental disabilities. Yet, there is still no treatment for it.

3. In an earlier study published in Nature Medicine, an international team of scientists discovered that the additional copy of chromosome 21 in Down's syndrome reduces the production of SNX27 in the brain and results in synaptic dysfunction. Synapse, a structure that permits nerve cells to pass chemical signals to each other, is known to have an important role in memory formation and its dysfunction could result in impairment. By re-introducing SNX27 into the brain, memory could be restored hence suggesting that SNX27 is an essential protein for memory and learning.

4. The protein's role in the pathway leading to memory impairment, however, remained unclear until scientists from IMCB utilised live-cell imaging techniques to elucidate the mechanism of memory impairment and illustrated how SNX27 attributes to synaptic dysfunction. The scientists observed that transmission of chemical signals between the nerve cells are facilitated by AMPA-receptors and the activity occurs on the brain cell surface. As SNX27 plays an important role in shuttling the AMPA-receptor
'/>"/>

Contact: Tan Yun Yun
tan_yun_yun@a-star.edu.sg
656-826-6273
Biomedical Sciences Institutes (BMSI)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Breakthroughs in Chikungunya research from A*STAR spell new hope for better treatment and protection
2. A*STAR scientists discover potential drug for deadly brain cancer
3. A*STAR scientists solve century-old mystery by finding stable haploid strains of Candida albicans
4. A*STAR scientists groundbreaking discovery of nucleus structure crucial to understanding diseases
5. A*STAR scientists discover novel hormone essential for heart development
6. A*STAR signs agreement with Nestlé to strengthen food & nutrition R&D in Singapore
7. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
8. Queens scientists seek vaccine for Pseudomonas infection
9. Scientists produce eye structures from human blood-derived stem cells
10. American Society of Plant Biologists honors early career women scientists
11. Brandeis scientists win prestigious prize for circadian rhythms research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... 2014  Spectra Automation, a trusted supplier ... and power generation industries, announced today the ... an easy-to-use and cost-effective data collection, analysis ... laboratories. Most upstream process ... systems. Accessing and consolidating data from these ...
(Date:9/29/2014)... study confirms that the exposure to tar tended to ... regular cigarettes. Similarly, exposure to nicotine tended to ... type of cigarette in several countries around the world. ... toxic chemicals in the smoke of these cigarettes are ... levels of chemicals in the smoke are not necessarily ...
(Date:9/29/2014)... at home should use ventilation when cooking with a ... after a new study showed an association between gas ... bronchitis. , "In homes where a gas stove was ... is higher than in homes where a gas stove ... professor in the College of Public Health and Human ...
Breaking Biology News(10 mins):Spectra Automation Introduces RECONN Bioprocess Manager 2Slim cigarette smokers not exposed to more harmful chemicals 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 3
... about food security, the U.S. Agency for International ... Virginia Tech,s Office of International Research, Education, and ... barriers in Africa. The African Food Security ... focus on enhancing production of staple food commodities, ...
... the number of bees and other pollinators is not, ... the results of an international study published in the ... Biology . , Co-author, CSIRO Entomology,s Dr Saul ... that demand for pollinators is still growing and some ...
... leading five projects within the VII Framework ... cement materials, nanomaterials for building safer aircraft, ... fisheries resources and new models of production. ... with leading companies in their activity sectors ...
Cached Biology News:USAID grant awarded to improve food security in Africa 2Pollinator decline not reducing crop yields just yet 2TECNALIA leads five projects within the VII Framework Program 2
(Date:10/1/2014)... 1, 2014  Discovery Laboratories, Inc. (Nasdaq: DSCO) ... a Phase II Small Business Innovation Research Grant ... the National Institute of Allergy and Infectious Diseases ... to support the development of the Company,s aerosolized ... to mitigate acute and chronic/late-phase radiation-induced lung injury. ...
(Date:10/1/2014)... Foster City, CA (PRWEB) October 01, 2014 ... century, it leaves no room for doubt that this century ... and innovations in the field of medicine science. The fact ... health problems is not unknown to the scientific community. Almost ... and pollution and therefore can be prevented with medical care ...
(Date:10/1/2014)... Award winning unified communications (UC) and ... collaboration bundles that combine next generation communication technologies. ... for low, flat rate fees. With four ... optimized solutions to meet their technology needs. , ... minutes (1K, 5K, 10K increments) or audio minutes ...
(Date:10/1/2014)... 2014 Industry leaders from ... engage around the theme, ,Commercial Opportunities in the Era ... Elsevier , a world-leading provider of ... host a gathering of some of the industry,s most ... healthcare today and in the future. The ...
Breaking Biology Technology:Discovery Labs Receives SBIR Grant Valued up to $3.0 Million to Support Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives SBIR Grant Valued up to $3.0 Million to Support Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3Fighting Mortality and Morbidity of Chronic Health Disorders during Open Access Week 2Fighting Mortality and Morbidity of Chronic Health Disorders during Open Access Week 3SoundConnect Launches New Audio, Web and Video Bundles 2Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 2Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 3
... , , , , , , Multiporator , , , ... Transfection Protocol , Protocol No. 4308 915.035 12/1999 ... , , , , , ... , days in culture, , ...
... , , , , , , , ... Protocol No. 4308 915.528 01/2002 , , , , , ... , Microorganism , Pseudomonas aeruginosa, ... Bacteria, gram negative, , , ...
... , , Multiporator / Electroporator 2510 , , , , , , ... Transformation Protocol , Protocol No. 4308 915.526 01/2002 , , ... , , , Microorganism , ... Cell type , Bacteria, gram positive, ...
Cached Biology Technology:Primary cells, rat heart muscle 2Pseudomonas aeruginosa 2Nocardia corallina 2
... jetSI-ENDO-FluoR is a tetramethylrhodamine-conjugated ... emission at 580 nm), the ... reagents are used to determine ... the intracellular delivery and trafficking ...
... Bruker Daltonics and Bruker BioSpins Metabolic ... metabolism studies, and analysis of complex ... system, an optional Avance NMR spectrometer ... evaluation and statistical analysis for applications ...
... of Tracker, plus software to note when the ... a food reward.The Spatial Behavior line is a ... camera, frame grabber, and feature extraction software and ... up to 6 moving animals. Software automatically ...
... Tracker w/ OutputCumulates a score of movement ... except that it.can track up to 6 subjects ... can be triggered. Can outpt a sync ... EEG. Can use animal location and timing ...
Biology Products: