Navigation Links
A*STAR scientists discover protein's role in human memory and learning functions
Date:2/19/2014

1. Scientists at A*STAR's Institute of Molecular and Cell Biology (IMCB) have identified the precise role of the protein, SNX27, in the pathway leading to memory and learning impairment. The study broadens the understanding of the brain's memory function and could be used to explain defects in the cognitive development of those with Down's syndrome. The newly established knowledge could potentially facilitate exploration of strategies to improve memory and learning abilities in Down's syndrome.

2. Down's syndrome is a genetic condition characterized by the presence of an additional copy of chromosome 21. About one in eight hundred new-borns is diagnosed with Down's syndrome. It is a condition that leads to impairments in both cognitive ability and physical growth that range from mild to moderate developmental disabilities. Yet, there is still no treatment for it.

3. In an earlier study published in Nature Medicine, an international team of scientists discovered that the additional copy of chromosome 21 in Down's syndrome reduces the production of SNX27 in the brain and results in synaptic dysfunction. Synapse, a structure that permits nerve cells to pass chemical signals to each other, is known to have an important role in memory formation and its dysfunction could result in impairment. By re-introducing SNX27 into the brain, memory could be restored hence suggesting that SNX27 is an essential protein for memory and learning.

4. The protein's role in the pathway leading to memory impairment, however, remained unclear until scientists from IMCB utilised live-cell imaging techniques to elucidate the mechanism of memory impairment and illustrated how SNX27 attributes to synaptic dysfunction. The scientists observed that transmission of chemical signals between the nerve cells are facilitated by AMPA-receptors and the activity occurs on the brain cell surface. As SNX27 plays an important role in shuttling the AMPA-receptor
'/>"/>

Contact: Tan Yun Yun
tan_yun_yun@a-star.edu.sg
656-826-6273
Biomedical Sciences Institutes (BMSI)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Breakthroughs in Chikungunya research from A*STAR spell new hope for better treatment and protection
2. A*STAR scientists discover potential drug for deadly brain cancer
3. A*STAR scientists solve century-old mystery by finding stable haploid strains of Candida albicans
4. A*STAR scientists groundbreaking discovery of nucleus structure crucial to understanding diseases
5. A*STAR scientists discover novel hormone essential for heart development
6. A*STAR signs agreement with Nestlé to strengthen food & nutrition R&D in Singapore
7. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
8. Queens scientists seek vaccine for Pseudomonas infection
9. Scientists produce eye structures from human blood-derived stem cells
10. American Society of Plant Biologists honors early career women scientists
11. Brandeis scientists win prestigious prize for circadian rhythms research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... Canada , April 17, 2015 ... growing security concerns, and technological advancement to drive ... until 2020   According ... Saudi Arabia Biometric Systems Market Forecast &  Opportunities, 2020 ", biometric systems ... is projected to register growth at CAGR of ...
(Date:4/14/2015)... , April 14, 2015 NXT-ID, Inc. ... biometric authentication company focused on the growing mobile commerce ... nominated for the 2015 New York Design Awards under ... Design100, New York City Design Awards are part of ... on over 2,500 ratings from the marketplace, industry and ...
(Date:4/13/2015)... 2015  higi, a leading cloud-based consumer engagement platform ... engage with their communities around health and wellness, announced ... secure API.  ... affordable, and convenient vehicle to receive validated health information ... The API will allow higi,s trusted partners, on ...
Breaking Biology News(10 mins):Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3
... the most stressful thing that can happen to anybody. But ... of traumatic experiences. Most humans come to terms with it ... How weaning takes place, however, can have a dramatic effect on ... this is so, at least for horses, comes from the latest ...
... different types of animals come together to form vast groups ... Researchers in France added another example to the list, reported ... huge Wels catfish, the world,s third largest and Europe,s largest ... from May 2009 to Feb. 2011 and found that they ...
... Kansas State University research team is serving up ... and staff. Junehee Kwon, associate professor of ... professor of hospitality management and dietetics, are co-principal ... United States Department of Agriculture Higher Education Challenge ...
Cached Biology News:The short goodbye: Weaning foals 2The short goodbye: Weaning foals 3On the menu: Research helps future restaurant managers reach out to customers with food allergies 2
(Date:5/1/2015)... 1, 2015 A new report ... drugs will reach $22.4bn in 2019. That revenue forecast ... and Market Prospects 2015-2025 ,  published in ... is to provide forecasts and qualitative analyses of the ... and consultancy in London, UK . ...
(Date:5/1/2015)... -- Albany Molecular Research Inc. (NASDAQ: AMRI ) ... President and Chief Executive Officer, will present at the ... on Wednesday, May 13, 2015 at 4:20 p.m. ET. ... can be accessed at AMRI,s Investor Relations web site at ... be archived for 90 days following the live presentation. ...
(Date:5/1/2015)... RESEARCH TRIANGLE PARK, N.C. , May 1, ... today that Roger Jeffs , Ph.D., President and Co-Chief ... update on the company,s business at the Deutsche Bank 40 ... Massachusetts . The presentation will take place ... and can be accessed via a live webcast on the ...
(Date:4/30/2015)... April 30, 2015  Roka Bioscience, Inc. (NASDAQ: ... advanced testing solutions for the detection of foodborne pathogens, ... first quarter of 2015 on May 7, 2015 after ... Bioscience will also host a conference call at 4:30 ... its first quarter financial results. During the conference call, ...
Breaking Biology Technology:Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 2Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 3Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 4Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 5AMRI to Present at the Bank of America Merrill Lynch 2015 Health Care Conference 2Roka Bioscience to Report First Quarter 2015 Financial Results On May 7, 2015 2
... - 11:00 a.m. ET; 8:00 a.m. PT, VANCOUVER ... (TSX: MGI; OTC: MGIFF), a clinical-stage developer of drugs ... on Tuesday,September 11, 2007 at 11:00 a.m. ET (8:00 ... quarter ended July 31, 2007. An update on,company activities ...
... Keynote Emphasizes Generic Industry Readiness and Questions Fiscal ... Social Responsibility of Delaying Biogenerics -, WASHINGTON, Sept. ... crossroads as decades-old patents,expire, and generic companies stand ready ... time to pass legislation enabling the U.S.,Food and Drug ...
... Sept. 6 NPS,Pharmaceuticals, Inc. (Nasdaq: NPSP ) ... for any and all of its outstanding 3.0% Convertible,Notes ... Eastern Time on,October 4, 2007, unless extended. The tender ... and the related letter of transmittal, is not,subject to ...
Cached Biology Technology:MIGENIX First Fiscal Quarter 2008 Financial Results Conference Call & Webcast Notification 2Biogenerics Will Save Billions, Says Hospira CEO 2Biogenerics Will Save Billions, Says Hospira CEO 3Biogenerics Will Save Billions, Says Hospira CEO 4NPS Pharmaceuticals Commences Tender Offer for 3.0% Convertible Notes Due 2008 2NPS Pharmaceuticals Commences Tender Offer for 3.0% Convertible Notes Due 2008 3NPS Pharmaceuticals Commences Tender Offer for 3.0% Convertible Notes Due 2008 4
... HISTAR detection systems provide linking and ... with species specific primary antibodies for ... Visualisation is accomplished using an ultra-sensitive ... polymer labelling technology. Secondary antibodies are ...
... • Enzyme concentration - 5 units/µL ... in higher yields ,• Leaves an 'A' ... DNA polymerase which exhibits very high activity ... applications. To ensure the quality of the ...
... Recombinant DNA polymerase from Thermus aquaticus expressed ... contamination; 1 tube of 250 units enzyme/tube ... (Low DNA), is the same enzyme as ... through a proprietary separation process to ensure ...
Our original highly-purified, robust Taq Polymerase which delivers consistently high yields and minimal background...
Biology Products: