Navigation Links
A*STAR scientists discover potential drug for deadly brain cancer
Date:9/4/2012

1. A*STAR scientists have identified a biomarker of the most lethal form of brain tumours in adults- glioblastoma multiforme. The scientists found that by targeting this biomarker and depleting it with a potential drug, they were able to prevent the progression and relapse of the brain tumour.

2. This research was conducted by scientists at A*STAR's Institute of Medical Biology led by Dr Prabha Sampath, Principal Investigator, in collaboration with A*STAR's Bioinformatics Institute (BII), and clinical collaborators from Medical University of Graz, Austria, and National University of Singapore. The research findings were published on Aug 23 in the scientific journal, Cell Reports from Cell Press.

3. The scientists found that the biomarker, miR-138, is highly expressed in cancer stem cells compared to normal neural stem cells. They thus carried out in vitro experiments to deplete miR-138 in these cancer stem cells with a potential drug, antimiR-138, to observe the effect. They found that when miR-138 is depleted, the cancer cells are completely destroyed. This is an important breakthrough as current therapies such as gamma radiation and surgical methods proved to be inadequate in treating these brain tumours, which tend to re-grow from cancer stem cells and become extremely lethal.

4. Dr Sampath said, "In this study we have identified a master regulator, miR-138, which is essential for the progression and relapse of a deadly form of brain cancer. By targeting this regulator we can effectively prevent the recurrence of this lethal form of cancer. This promising finding will pave the way for the development of a novel therapy to successfully treat the aggressive forms of brain cancer."

5. Studies were also done in mice to determine whether antimiR-138 could effectively inhibit the growth of tumours. These experiments were conducted with a control drug as well, revealing that tumours continued to be present when m
'/>"/>

Contact: Vithya Selvam
vithya_selvam@a-star.edu.sg
656-826-6291
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Breakthroughs in Chikungunya research from A*STAR spell new hope for better treatment and protection
2. Singapore scientists find genes associated with glaucoma, a major cause of eye blindness
3. EARTH: Antarctic trees surprise scientists
4. Rice, MD Anderson scientists probe mystery of operon evolution
5. Coral scientists use new model to find where corals are most likely to survive climate change
6. Scientists call policy-makers to be scale-aware
7. Chinese scientists successfully crack the genome of diploid cotton
8. Scientists find oldest occurrence of arthropods preserved in amber
9. To cap or not to cap: Scientists find new RNA phenomenon that challenges dogma
10. MBL scientists discover nerves control iridescence in squid’s remarkable electric skin
11. Scientists identify new gene that influences survival in ALS
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A*STAR scientists discover potential drug for deadly brain cancer
(Date:9/23/2014)... a lot greener thanks to a novel technique developed ... solar energy to accelerate tailings pond reclamation efforts by ... light source to treat oil sands process affected water ... and James Bolton have found that using the sunlight ... as efficiently but at a much lower cost. , ...
(Date:9/23/2014)... The National Institutes of Health will award funds to ... Drug Screening program to improve ways of predicting drug ... to refine existing 3-D human tissue chips and combine ... complex functions of the human body. Led by the ... will support 11 institutions at $17 million in 2014 ...
(Date:9/23/2014)... Company has secured $21 million in a Series C ... the Company,s cancer immunotherapy pipeline and advance its lead ... the round, with participation from Majuven and all existing ... Harbinger Venture Capital. , Eureka is engaged in ... mimic the functions of a T cell receptor, a ...
Breaking Biology News(10 mins):Solar energy-driven process could revolutionize oil sands tailings reclamation 2NIH funds next phase of Tissue Chip for Drug Screening program 2NIH funds next phase of Tissue Chip for Drug Screening program 3NIH funds next phase of Tissue Chip for Drug Screening program 4
... This release is available in German . ... disk currently consists of about 3 million magnetic atoms. Researchers ... memory with one bit per molecule. By an electric pulse, ... magnetic state and a low-conductive, non-magnetic state. This novel correlation ...
... in most developing countries to meet the United Nations, ... from hunger by 2015 compared with 1990 levels, according ... and weight, published today in the Lancet . ... improved overall since 1985, one in five infants and ...
... medicine for Parkinson,s disease, by investigating signs of the ... respond to drug treatments. The study was funded by ... skin cells from patients with genetically inherited forms of ... found that neurons derived from individuals with distinct types ...
Cached Biology News:Nature: Molecule changes magnetism and conductance 2Developing world has less than 5 percent chance of meeting UN child hunger target, study estimates 2Developing world has less than 5 percent chance of meeting UN child hunger target, study estimates 3Patient-derived stem cells could improve drug research for Parkinson's 2Patient-derived stem cells could improve drug research for Parkinson's 3Patient-derived stem cells could improve drug research for Parkinson's 4
(Date:9/23/2014)... , Sept. 23, 2014 News ... India devoted to genome-based research for ... Genomics (NIBMG) is taking a bite out of oral ... among males in India with the ... solutions from DataDirect Networks (DDN). , To fuel its ...
(Date:9/23/2014)... , Sept. 23, 2014   GenoSpace , ... comprehensive suite of tools to enable the broad use ... announced that it has been awarded Phase I of ... from the National Institutes of Health (NIH) to enable ... Logo - http://photos.prnewswire.com/prnh/20140922/147649 ...
(Date:9/23/2014)... Dr. Williams says, “Find The Black Box ... a three phase process that can lead to the ... would go far beyond anything previously imagined. First everyone ... healthcare.” , “Every effort to improve the quality of ... progress throughout that system because all of the experts ...
(Date:9/22/2014)... who were treated with a statin in the hospital ... likely to survive than those who were not, according ... . This study was conducted by the same researchers ... can improve survival in victims of ischemic stroke., Ischemic ... a blood vessel that blocks blood from reaching areas ...
Breaking Biology Technology:National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 2National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 3National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 4National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 5GenoSpace Awarded Fast Track SBIR Grant to Enable Data Access and Cohort Construction for Biorepositories 2Dr. Ira Williams Offers the Healthcare Solution Necessary for Patient Safety Improvement 2Statin use during hospitalization for hemorrhagic stroke associated with improved survival 2
... of Allowance of European Patent Application Covering Its Core Natural ... Applications Protection Rights to All Cytokine ... ... (GO), a biotechnology,company dedicated to the discovery and development of improved ...
... 24 Researchers at 28th annual,National Academy ... City this,weekend will present data to help ... breast cancer survivors affected by,"Chemobrain". Chemobrain is ... types of cancer. It is associated with ...
... 24 /PRNewswire-FirstCall/ - Oncothyreon Inc. (Nasdaq:,ONTY) (TSX:ONY), a ... products for the treatment of cancer, today,announced that ... scheduled to present at the 7th Annual BIO ... 2008 at 8:00 a.m. Pacific Time., A ...
Cached Biology Technology:GenOdyssee Receives Broad Product Applications Protection in EU for Founding Natural Evolution Technology 2GenOdyssee Receives Broad Product Applications Protection in EU for Founding Natural Evolution Technology 3GenOdyssee Receives Broad Product Applications Protection in EU for Founding Natural Evolution Technology 4Brain Fitness Program Offers Hope for Breast Cancer Survivors Suffering From 'Chemobrain' 2
...
Recalibration of HL-2000-CAL products...
Mature rat whole blood (Sprague-Dawley, averaging 7-8 weeks of age, either sex) is collected at the time of slaughter and processed within 45 minutes. It is then filtered through gauze, pooled in an ...
Several Pichia pastoris strains are available to allow you to optimize expression and recovery of your protein of interest. Table 1 provides information to help you choose the appropriate strain....
Biology Products: