Navigation Links
A*STAR scientists discover novel hormone essential for heart development
Date:12/6/2013

1. Scientists at A*STAR's Institute of Medical Biology (IMB) and Institute of Molecular and Cellular Biology (IMCB) have identified a gene encoding a hormone that could potentially be used as a therapeutic molecule to treat heart diseases. The hormone - which they have chosen to name ELABELA - is only 32 amino-acids long, making it amongst the tiniest proteins made by the human body.

2. The team led by Dr Bruno Reversade carried out experiments to determine ELABELA's function, since its existence was hitherto unsuspected. Using zebrafish designed to specifically lack this hormone, they uncovered that ELABELA is indispensable for heart formation. Zebrafish embryos without this gene had rudimentary or no heart at all (see Figure 1). Their results were published in the 5 December 2013 online issue of Developmental Cell.

3. Deficiencies in hormones are the cause of many diseases, such as the loss of insulin or insulin resistance, that results in diabetes, and irregularities in appetite and satiety hormones that can cause obesity. Hormones are known to control functions such as sleep, appetite and fertility. However, this is the first time that scientists have revealed the existence of a conserved hormone playing such an early role during embryogenesis, effectively orchestrating the development of an entire organ.

4. The team also found that ELABELA uses a receptor previously believed to be specific to APELIN, a blood-pressure controlling hormone. This receptor called APJ or Apelin Receptor has dual functions - it first conveys signals from ELABELA and then from APELIN. Mutations in the Apelin Receptor also prevent the heart from forming. Zebrafish bereft of the Apelin Receptor are referred to as the Grinch, in reference to the cold and heartless cartoon character created by Dr. Seuss in 1957.

5. ELABELA has also been found to be expressed in human embryonic stem cells , indicating that it might have other functions beyond its
'/>"/>

Contact: Vithya Selvam
vithya_selvam@a-star.edu.sg
656-826-6291
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert  

Page: 1 2

Related biology news :

1. A*STAR scientists groundbreaking discovery of nucleus structure crucial to understanding diseases
2. A*STAR scientists solve century-old mystery by finding stable haploid strains of Candida albicans
3. A*STAR scientists discover potential drug for deadly brain cancer
4. Breakthroughs in Chikungunya research from A*STAR spell new hope for better treatment and protection
5. Scientists unearth secrets of Périgord truffles, the culinary black diamond
6. Top scientists to present at Epigenetic Control and Cellular Plasticity symposium
7. Salk scientists crack riddle of important drug target
8. Scientists stitch up photosynthetic megacomplex
9. Scripps Research Institute scientists achieve most detailed picture ever of key part of hepatitis C
10. UCLA research may help scientists understand what causes pregnancy complications
11. Scientists discover how leukemia cells exploit enhancer DNA elements to cause lethal disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A*STAR scientists discover novel hormone essential for heart development
(Date:6/1/2015)... According to a new market research report ... & Touchless), Application (Consumer Electronics, Automotive, & Others), Product ... Forecast to 2020", published by MarketsandMarkets, the Gesture Recognition ... Billion by 2020, at a CAGR of 28.23% between ... data T ables and   86   F ...
(Date:6/1/2015)... , June 1, 2015 ... "Next Generation Biometrics Market by Application (Government, Military ... Travel & Immigration, and Security), Technology (Face Recognition, ... Signature Recognition, Vein Recognition, and Others), Function (Contact ... , Europe , APAC, ...
(Date:5/29/2015)... DUBLIN , May 28, 2015 ... the addition of the "Facial Recognition Market ... User - Global Forecast to 2020" report ... years, have seen facial recognition technology become more ... technology to gain traction and investment from the ...
Breaking Biology News(10 mins):Gesture Recognition & Touchless Sensing Market Worth $23.55 Billion by 2020 2Gesture Recognition & Touchless Sensing Market Worth $23.55 Billion by 2020 3Gesture Recognition & Touchless Sensing Market Worth $23.55 Billion by 2020 4Next Generation Biometrics Market Worth $24,448.84 Million by 2020 2Next Generation Biometrics Market Worth $24,448.84 Million by 2020 3Next Generation Biometrics Market Worth $24,448.84 Million by 2020 4Global advanced Facial Recognition Market Expected to Grow From $2.77 Billion in 2015 to $6.19 Billion in 2020, at an Estimated CAGR of 17.4% 2
... Two proteins interact in a previously unknown molecular mechanism ... for the causes of defective organs in fetuses, metastatic ... Children,s Hospital Medical Center. Reporting their work in ... researchers said the mechanism coordinates cell identity and behavior ...
... shells to bones, the skeletons of organisms contain small ... levels of these elements provide important clues to past ... to relate impurity contents to the ancient environments in ... 31 issue of Science magazine, Allison Stephenson, ...
... have unlocked part of the mystery underlying a childhood eye disease. ... end up with missing or extra pieces of DNA. The ... (CNVs). The U of A research team had previously shown how ... glaucoma a disease that can lead to blindness. In their ...
Cached Biology News:New regulatory mechanism discovered for cell identify and behavior in forming organs 2New regulatory mechanism discovered for cell identify and behavior in forming organs 3Bare bones of crystal growth: Biomolecules enhance metal contents in calcite 2
(Date:6/2/2015)... 2015 Meet ARGUS, The World,s ... & Read People. Analyze emotions and predict actions. Explore ... the very first Responsive-RPG: "The Eye: Genesis". ... , , , https://www.youtube.com/watch?v=B1ZEtAZ2Yf8 ... your inner feelings - and those of others. Being ...
(Date:6/2/2015)... 2, 2015   Hospira, Inc. (NYSE: ... that its partner, Celltrion – a global biopharmaceutical company – ... Surveillance Agency in Brazil – ... for use in Brazil . The ... and sells biosimilar infliximab in 26 European countries and ...
(Date:6/2/2015)... Pa. , June 2, 2015   BioClinica ... and technology provider, today announced that David Peters ... been named Executive Vice President and Chief Financial Officer ... 2015. Peters brings more than 25 years ... pharmaceutical services. "David has extensive and deep knowledge in ...
(Date:6/2/2015)... June 2, 2015  RXi Pharmaceuticals Corporation ... focused on discovering and developing innovative therapies ... ophthalmology, today announced that Dr. Pamela Pavco ... at the 23 rd World Congress ... will include in-depth presentations by world-class clinicians ...
Breaking Biology Technology:ARGUS - The World's First Inner Emotion Scanner Launches on KickStarter 2ARGUS - The World's First Inner Emotion Scanner Launches on KickStarter 3ANVISA Approves First Infliximab Biosimilar in Brazil 2ANVISA Approves First Infliximab Biosimilar in Brazil 3ANVISA Approves First Infliximab Biosimilar in Brazil 4ANVISA Approves First Infliximab Biosimilar in Brazil 5BioClinica Names David Peters New Chief Financial Officer 2RXi Pharmaceuticals to Present at the 23rd World Congress of Dermatology 2RXi Pharmaceuticals to Present at the 23rd World Congress of Dermatology 3RXi Pharmaceuticals to Present at the 23rd World Congress of Dermatology 4
... , Baltimore Convention Center ... BALTIMORE, Aug. 11 This summit will attract more than 1,200 ... It will feature more than 100 speakers, including governors, federal officials, ... cell policies, scientific breakthroughs, and human-interest stories. This is your ...
... , SAN FRANCISCO, Aug. 11 ... stage biopharmaceutical company developing a proprietary breakthrough class of targeted ... private placement financing with gross proceeds of US $5,123,521, exceeding ... anticipated on or before September 15, 2009, with additional proceeds ...
... 11 /PRNewswire-Asia-FirstCall/ -- American Oriental,Bioengineering, Inc. (NYSE: ... to improving health through the development, manufacture and,commercialization of ... ("OTC"),products in China, announced today that the Audit Committee ... of Ernst & Young Hua Ming ("EY") as,the Company,s ...
Cached Biology Technology:World Stem Cell Summit to Be Held in Baltimore 2Jennerex Closes $5 Million First Tranche of Series C Financing 2
DDO Immunogen: DDO (NP_003640, 270 a.a. ~ 370 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Goat polyclonal to T7 tag (Agarose) Immunogen: Goats were immunized with MASMTGGQQMG (T7) conjugated to KLH.After multiple immunizations in Freund's adjuvant, serum was collected....
... WinList come straight from the folks who ... automatic region positioning, N-Stat regions, and presentation-quality ... thoughtful conversations, and careful design. Of course, ... are still there, too. WinList leads the ...
C/EBPdelta Antibody Shipping Temperature: Cold Storage Temperature: -20C...
Biology Products: