Navigation Links
A 'Kit' for increasing insulin production
Date:7/17/2012

Scientists from Western University in London, Canada and the Children's Health Research Institute, an Institute within the Lawson Health Research Institute, have identified the critical role of a receptor called c-Kit in the development and function of insulin-producing beta cells, making it an exciting therapeutic target for the management of diabetes.

The research, led by Rennian Wang, demonstrated that overexpression of c-Kit not only leads to increased insulin production but also counteracts the early diabetic effects of a high-fat diet. The paper and an accompanying commentary, are published in the August issue of Diabetologia, and featured in the Research Highlights in Nature Reviews Endocrinology (June 5).

Diabetes is one of the most common metabolic diseases affecting over 25 million Americans and 2 million Canadians. It's associated with a multitude of complications leading to considerable morbidity and a major medical as well as financial burden on society.

One of the major defects in diabetes is the loss of beta cells in the pancreatic islet. Wang and colleagues, including Zhi Chao Feng, a PhD candidate and first author on the paper, developed a transgenic mouse model (c-Kit Wv) which overexpressed c-Kit, specifically in beta cells. "When c-Kit is overexpressed, we observed a significant improvement in beta cell function and survival," says Wang, a Professor in the Departments of Physiology and Pharmacology, and Medicine at Western's Schulich School of Medicine & Dentistry. "You can even rescue c-Kit mutant mice from the early onset of diabetes, and protect against high-fat diet-induced beta cell defects. This is a novel finding and is being reported for the first time."

Wang believes ongoing research into c-Kit and its underlying mechanisms, will pave the way to develop strategies to preserve and restore function to beta cells as a cure for both type 1 and type 2 diabetes. This study was funded by the Canadian Institutes of Health Research.


'/>"/>

Contact: Kathy Wallis
kwallis3@uwo.ca
519-661-2111 x81136
University of Western Ontario
Source:Eurekalert  

Related biology news :

1. Made-in-Singapore H5N1 diagnostic kit -- detects all known strains of H5N1 virus with a single test
2. More freedom of discretion for KIT
3. KIT researchers succeed in realizing a new material class
4. Robotic cats, a kitten mummy and a major UK vet gathering
5. KIT: Processes at the surface of catalysts
6. Increasing levels of carbon dioxide in Arctic coastal seas
7. Loss of biodiversity increasingly threatens human well-being: UBC, University of Michigan research
8. Increasing predator-friendly land can help farmers reduce costs
9. Increasing water scarcity in Californias Bay-Delta will necessitate trade-offs; hard decisions needed to balance various environmental risks
10. Increasing clarity for medics in suspected physical abuse cases
11. Surprising pine beetle breeding habits help explain increasing tree damage, says CU study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A 'Kit' for increasing insulin production
(Date:11/16/2016)... Calif. , Nov. 16, 2016 ... user experience and security for consumer electronics, and ... the financial and retail industry, today announced a ... and convenient way to authenticate users of mobile ... Sensory,s TrulySecure™ software which requires no ...
(Date:11/14/2016)... Fla., Nov. 14, 2016  xG Technology, Inc. ("xG" ... providing critical wireless communications for use in challenging operating ... September 30, 2016. Management will hold a conference call ... 5:00 p.m. Eastern Time (details below). Key ... a $16 million binding agreement to acquire Vislink Communication ...
(Date:6/22/2016)... 2016  The American College of Medical Genetics and Genomics ... as one of the fastest-growing trade shows during the ... Bellagio in Las Vegas . ... growth in each of the following categories: net square feet ... of attendees. The 2015 ACMG Annual Meeting was ranked 23 ...
Breaking Biology News(10 mins):
(Date:12/5/2016)... , Dec 5, 2016 Research ... report "DNA Sequencing - Technologies, Markets and Companies" ... ... report briefly reviews basics of human genome variations, development of ... are described as well as companies developing them. Various applications ...
(Date:12/4/2016)... , Dec. 3, 2016  In five studies ... Hematology (ASH) Annual Meeting and Exposition in ... engineering methods to improve the delivery of life-saving treatments ... new methods are designed to carry therapies directly to ... most, which could provide a substantial advantage over traditional, ...
(Date:12/2/2016)... 2016  The Multiple Myeloma Research Foundation (MMRF) today ... Study SM —the largest and most comprehensive study driving ... myeloma—will be presented at the 58 th American ... San Diego from December 3-6. ... as well as identify pathways and targets for new ...
(Date:12/2/2016)... ... ... ACEA Biosciences, Inc. announced today that it will be presenting updated efficacy ... Conference on Lung Cancer 2016, taking place in Vienna, Austria December 3rd-8th. , ... AC0010 in patients with advanced non-small cell lung cancer harboring the EGFR T790M resistance ...
Breaking Biology Technology: