Navigation Links
A 'Kit' for increasing insulin production
Date:7/17/2012

Scientists from Western University in London, Canada and the Children's Health Research Institute, an Institute within the Lawson Health Research Institute, have identified the critical role of a receptor called c-Kit in the development and function of insulin-producing beta cells, making it an exciting therapeutic target for the management of diabetes.

The research, led by Rennian Wang, demonstrated that overexpression of c-Kit not only leads to increased insulin production but also counteracts the early diabetic effects of a high-fat diet. The paper and an accompanying commentary, are published in the August issue of Diabetologia, and featured in the Research Highlights in Nature Reviews Endocrinology (June 5).

Diabetes is one of the most common metabolic diseases affecting over 25 million Americans and 2 million Canadians. It's associated with a multitude of complications leading to considerable morbidity and a major medical as well as financial burden on society.

One of the major defects in diabetes is the loss of beta cells in the pancreatic islet. Wang and colleagues, including Zhi Chao Feng, a PhD candidate and first author on the paper, developed a transgenic mouse model (c-Kit Wv) which overexpressed c-Kit, specifically in beta cells. "When c-Kit is overexpressed, we observed a significant improvement in beta cell function and survival," says Wang, a Professor in the Departments of Physiology and Pharmacology, and Medicine at Western's Schulich School of Medicine & Dentistry. "You can even rescue c-Kit mutant mice from the early onset of diabetes, and protect against high-fat diet-induced beta cell defects. This is a novel finding and is being reported for the first time."

Wang believes ongoing research into c-Kit and its underlying mechanisms, will pave the way to develop strategies to preserve and restore function to beta cells as a cure for both type 1 and type 2 diabetes. This study was funded by the Canadian
'/>"/>

Contact: Kathy Wallis
kwallis3@uwo.ca
519-661-2111 x81136
University of Western Ontario
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Made-in-Singapore H5N1 diagnostic kit -- detects all known strains of H5N1 virus with a single test
2. More freedom of discretion for KIT
3. KIT researchers succeed in realizing a new material class
4. Robotic cats, a kitten mummy and a major UK vet gathering
5. KIT: Processes at the surface of catalysts
6. Increasing levels of carbon dioxide in Arctic coastal seas
7. Loss of biodiversity increasingly threatens human well-being: UBC, University of Michigan research
8. Increasing predator-friendly land can help farmers reduce costs
9. Increasing water scarcity in Californias Bay-Delta will necessitate trade-offs; hard decisions needed to balance various environmental risks
10. Increasing clarity for medics in suspected physical abuse cases
11. Surprising pine beetle breeding habits help explain increasing tree damage, says CU study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A 'Kit' for increasing insulin production
(Date:12/22/2014)...  NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) ("NXT-ID" ... growing mobile commerce market, announces it has retained famous pickpocket, ... 2015 International CES debut of the Wocket™ biometric smart wallet.  ... the NXT-ID booth January 6th and 7 th , 2015, ...
(Date:12/19/2014)... MOUNTAIN VIEW, Calif. , Dec. 18, 2014  23andMe, Inc., ... a study that pinpoints fine-scale differences in genetic ancestry of ... Since immigrants first arrived more than four hundred ... served as a meeting place for peoples from different continents. ...
(Date:12/17/2014)... RALEIGH, N.C. , Dec. 16, 2014 Valencell, ... licensed its PerformTek biometric technology to industry leaders such ... highly accurate, clinically validated, biometric wearable products. These products ... 6-9 in Las Vegas . ...
Breaking Biology News(10 mins):NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 423andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2
... molecule consisting of two "cages" of metallic atoms bound to ... a new weapon in the anti-HIV arsenal, researchers at UT ... and its variants appear to fight HIV protease, an enzyme ... of the key drugs used to fight HIV/AIDS, but they ...
... area of the brain that records what the eye ... Rice University in Houston. , The research, published the ... National Academy of Sciences' (PNAS) online Early Edition, suggests ... visual information can be sent. , For the study, ...
... it on the street tomorrow? What if that alien didn't ... laboratory right here on Earth and functioned differently from other ... of an answer. In a new book, the University of ... biological classification system, to account for a variety of life ...
Cached Biology News:Metal-containing compounds show promise as HIV weapon 2Out of sight, out of mind? Not necessarily 2New book expands biological classifications to account for 'alien' life 2New book expands biological classifications to account for 'alien' life 3
(Date:1/22/2015)... Protocol Networks brings independent technology consulting to the ... consultants, Protocol Networks has recently announced its expansion into ... his company has attracted several clients in The Constitution ... as others. With the success of these engagements, Rogers ...
(Date:1/22/2015)... Dr. Greg Leyer of UAS Labs recently was invited ... seminar on probiotics in San Diego, CA. , The ... for health care professionals. This year’s pre-conference seminar was held ... health. Dr. Leyer spoke about the emerging topics and science ...
(Date:1/22/2015)... BRUNSWICK , Nueva Jersey , 22 de ... Award for Biomedical Research abre hoy su llamada a ... personas cuya investigación científica ha hecho, o tiene el ... la salud humana. Las nominaciones se aceptarán hasta el ...
(Date:1/22/2015)... PRINCETON, N.J. , Jan. 22, 2015  Derma ... tissue regeneration company focused on advanced wound care, ... from placental tissues, have been added to the ... announcement increases the opportunity for the AMNIOEXCEL® and ...
Breaking Biology Technology:Protocol Networks Brings Independent Technology Consulting to the Constitution State 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5
... With Broad ... Portfolio of IV Products, ... ) announced today that Novation, the University HealthSystem,Consortium,s (UHC) contracting ... of UHC valued at over $200 million over the,contract term. ...
... SEATTLE, Oct. 9 Cell Therapeutics, Inc. (CTI),(Nasdaq: CTIC ; MTAX) ... October 10 at 12:45 pm at,the Palace Hotel in San Francisco. ... after the presentation. The webcast can be accessed at, http://www.cticseattle.com . ... BIO CEO & Investor ...
... Mass., Oct. 9 Tandem Labs, a ... and,pharmacokinetic (PK)/pharmacodynamic (PD) services to the pharmaceutical,industry, ... SCIEX API 5000(TM),and 4000(TM) LC/MS/MS systems for ... acquisition doubles the facility,s current triple,quadrupole LC/MS/MS ...
Cached Biology Technology:Baxter and Novation Sign Multi-Year Contract Extension Valued at Over $200 Million for Medication Delivery Products 2Baxter and Novation Sign Multi-Year Contract Extension Valued at Over $200 Million for Medication Delivery Products 3Tandem Labs' New England Facility Doubles Discovery Support Capacity - Increasing Foothold in New England 2
...
...
... Specificity: This antibody recognizes murine ... cross-react with other related IRF ... with murine IRF7 protein was ... of the 293T cells transfected ...
...
Biology Products: