Navigation Links
A CNIO team reduces the size of the human genome to 19,000 genes
Date:7/3/2014

earchers mapped these proteins to the corresponding regions of the genome. They analysed thousands of genes that were annotated in the human genome, but that did not appear in the proteomics analysis and concluded: "1,700 of the genes that are supposed to produce proteins almost certainly do not for various reasons, either because they do not exhibit any protein coding features, or because the conservation of their reading frames does not support protein coding ability, "says Tress.

One hypothesis derived from the study is that more than 90% of human genes produce proteins that originated in metazoans or multicellular organisms of the animal kingdom hundreds of millions of years ago; the figure is over 99% for those genes whose origin predates the emergence of primates 50 million years ago.

"Our figures indicate that the differences between humans and primates at the level of genes and proteins are very small," say the researchers. David Juan, author and researcher in the Valencia lab, says that "the number of new genes that separate humans from mice [those genes that have evolved since the split from primates] may even be fewer than ten." This contrasts with the more than 500 human genes with origins since primates that can be found in the current annotation. The researchers conclude: "The physiological and developmental differences between primates are likely to be caused by gene regulation rather than by differences in the basic functions of the proteins in question."

DOING MORE WITH LESS

The sources of human complexity lie more in how genes are used rather than on the number of genes, in the thousands of chemical changes that occur in proteins or in the control of the production of these proteins by non-coding regions of the genome, which comprise 90% of the entire genome and which have been described in the latest findings of the international ENCODE project, a Project in which the Valencia team participa
'/>"/>

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Soy-based S-equol supplement reduces metabolic syndrome risk factors
2. Minimally invasive treatment for ruptured aneurysm: Safe, reduces mortality
3. Laparoscopy reduces the risk of small-bowel obstruction
4. Hot sauce ingredient reduces beer belly fat as a weight-loss surgery alternative
5. The absence of elephants and rhinoceroses reduces biodiversity in tropical forests
6. Drugs from lizard saliva reduces the cravings for food
7. New study: Snacking on raisins significantly reduces overall post-meal blood sugar levels
8. Cystic fibrosis makes airways more acidic, reduces bacterial killing
9. Study in mice discovers injection of heat-generating cells reduces belly fat
10. Eating well during pregnancy reduces babys obesity risk regardless of moms size
11. RTS,S malaria candidate vaccine reduces malaria by approximately one-third in African infants
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A CNIO team reduces the size of the human genome to 19,000 genes
(Date:8/27/2014)... Warwick research finds , Gamblers show the same ... research has shown. , Researchers, led by Dr Elliot ... conducted tests that found that both human gamblers and ... than low-value rewards. , Published in Biology Letters ... the important role that memories of previous biggest wins ...
(Date:8/26/2014)... over a colony of harmful bacteria, biofilms make ... protected in a biofilm pose a significant health ... to treatment, and biofilm-protected bacteria account for some ... and are 50 to 1,000 times more resistant ... essence, we may have stumbled onto a magic ...
(Date:8/26/2014)... In recent years, increasing pressure from policymakers, consumers, ... targets that go beyond reducing the pollutants they ... and lakes. Today companies must also assess environmental ... the mining of primary materials to the use ... has given rise to the discipline known as ...
Breaking Biology News(10 mins):Gamblers are greedy bird-brains, University of Warwick research finds 2Breakthrough antibacterial approach could resolve serious skin infections 2Breakthrough antibacterial approach could resolve serious skin infections 3Yale journal explores advances in sustainable manufacturing 2
... Candida albicans inconspicuously lives in our bodies until it ... go on the offensive. The fungus, known for causing yeast ... as candidemia in immunocompromised patients. An in vivo study, published ... can distinguish between a healthy and an unhealthy host and ...
... The northern spotted owl, a threatened species in ... run from active management of the forest lands that ... stand-replacing fire, researchers conclude in a recent study. ... or other fuel reduction activities in areas with high ...
... Antarctic Program Blue Ribbon Panel, commissioned by the ... (OSTP) and the National Science Foundation (NSF) released ... through Increased Logistical Effectiveness. The report is a ... containing numerous specific recommendations for the U.S. logistics ...
Cached Biology News:How a common fungus knows when to attack 2Active forest management to reduce fire could help protect northern spotted owl 2Blue Ribbon Panel unveils findings on logistical improvements to support Antarctic science 2
(Date:8/27/2014)... , Aug. 27, 2014 Reportlinker.com ... available in its catalogue: Global Chelating ... About Chelating Agent A chelating ... covalent bonds with metal ions, thereby forming a ... some metal-ions have on chemical processes, formulations, and ...
(Date:8/27/2014)... Aug. 27, 2014  Lisa Kulik saw fireworks for ... 4 holiday, thanks to a groundbreaking retinal implant co-invented ... renowned clinician-researcher at the University of Southern California (USC) ... Peoria, Ariz. resident who has retinitis ... of sight. On June 2, she became the first ...
(Date:8/27/2014)... “We are honored to be named to ... CEO of Radiant Sage. “We are offering truly ground-breaking ... corelab market to a different level. We are ... efficiently and effectively manage the massive amounts of medical ... and read by trained physicians. Being recognized by technology ...
(Date:8/27/2014)... , Aug. 27, 2014 Reportbuyer.com ... The Graphene Opportunity - A Rational View ... Graphene The New Nanotech? A similar amount ... of applications ranging from microelectronics to water treatment, ... announced the availability of the Graphene Opportunity Report, ...
Breaking Biology Technology:Global Chelating Agents Market 2014-2018 2Global Chelating Agents Market 2014-2018 3Global Chelating Agents Market 2014-2018 4USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 2USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 3USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 4USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 5Radiant Sage Named to CIOReview List of 100 Most Promising Technology Companies 2The Graphene Opportunity - A Rational View 2The Graphene Opportunity - A Rational View 3The Graphene Opportunity - A Rational View 4
... , Amsterdam Molecular Therapeutics (Euronext: AMT), ... today that it has filed,a request for re-examination of ... European Medicines Agency.,Glybera is a gene therapy for the ... re-examination of,the dossier will be completed by the end ...
... a combination of sophisticated computer modeling and advanced ... team led by the University at Buffalo (UB) ... Technology (NIST), the Molecular Foundry at Lawrence Berkeley ... relatively simple processing flaws can seriously degrade the ...
... 7, 2011 For the first time since stem ... isolated a human blood stem cell in its purest ... regenerating the entire blood system. This breakthrough opens the ... to treat cancer and other debilitating diseases more effectively. ...
Cached Biology Technology:Amsterdam Molecular Therapeutics Files Glybera® European Marketing Application for Re-examination 2Graphene: What can go wrong? new studies point to wrinkles, process contaminants 2"Pure" Human Blood Stem-Cell Discovery Opens Door to Expanding Cells for More Clinical Use 2"Pure" Human Blood Stem-Cell Discovery Opens Door to Expanding Cells for More Clinical Use 3