Navigation Links
A CNIO study finds a 'molecular scaffolding' that maintains skin structure and organisation
Date:1/16/2014

The human body is daily exposed to external assaults such as bacteria, ultraviolet light or chemical agents. Skin, the largest organ of the body, is the first line of defense against these agents. Skin performs this function thanks to the close connections established between its cells (e.g. adherens junctions). The loss of cell adhesion between these cells is related to inflammatory diseases and cancer, hence the special interest in this area of research over the past years.

A study by the Spanish National Cancer Research Centre (CNIO), featured on the cover of the Journal of Cell Biology, shows how interactions between skin stem cellsthe cells responsible for the constant renewal of skinmaintain the architecture of this organ. "We knew that these junctions were important in skin stem cells but the cellular components involved in their structure and function were not yet understood", says Mirna Prez-Moreno, head of the Epithelial Cellular Biology Group that led the study.

Using skin cells derived from mice, researchers have discovered that one of the key elements in the formation and stabilisation of these junctions are microtubules, tubular structures that are part of all cells and that serve as pillars to maintain their form and function.

"We have seen for the first time that skin stem-cell microtubules connect with cell-cell junctions to form velcro-like structures that hold the cells together", says Marta Shahbazi, a researcher on Prez-Moreno's team and the first author of the study.

The connection between these two cellular componentsmicrotubules and cell-cell junctionsoccurs via the interaction between the CLASP2 and p120 catenin proteins, linked to microtubules and cell junctions respectively.

"We found that the abscence of CLASP2 or p120 catenin in epidermal stem cells caused a loss of their adhesion, and therefore the structure of these cells", says Shahbazi.

"Our results will open up new paths for exploring how these proteins regulate skin physiology", says Prez-Moreno, adding that this knowledge will be "important for the possible development of future regenerative or anti cancer therapies".


'/>"/>

Contact: Nuria Noriega
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert  

Related biology news :

1. Wild sparrow study traces social behaviors in the field to specific gene
2. Illinois study identifies 3 risk factors most highly correlated with child obesity
3. Multiple myeloma study uncovers genetic diversity within tumors
4. Nature study discovers chromosome therapy to correct a severe chromosome defect
5. Study shows large carnivore numbers and range declining worldwide
6. Virginia Tech engineer receives NSF grant to study Colorado flood effects on antibiotic resistance
7. New study: US power plant emissions down
8. Study of Nepalese pilgrims challenges diagnosis of acute mountain sickness
9. New study finds extreme longevity in white sharks
10. Study discovers natural hybridization produced dolphin species
11. Penn biologists establish new method for studying RNAs regulatory footprint
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A CNIO study finds a 'molecular scaffolding' that maintains skin structure and organisation
(Date:3/22/2017)... , March 21, 2017 Optimove ... used by retailers such as 1-800-Flowers and AdoreMe, ... — Product Recommendations and Replenishment. Using Optimove,s machine learning ... personalized product and replenishment recommendations to their customers ... on predictions of customer intent drawn from a ...
(Date:3/20/2017)... March 20, 2017 At this year,s CeBIT Chancellor ... biometrics manufacturer DERMALOG. The Chancellor came to the DERMALOG stand together with ... this year,s CeBIT partner country. At the largest German biometrics company the ... fingerprint, face and iris recognition as well as DERMALOG´s multi-biometrics system.   ... ...
(Date:3/16/2017)... CeBIT 2017 - Against identity fraud with DERMALOG solutions "Made in ... ... combined in one project, multi-biometric solutions provide a crucial contribution against identity fraud. (PRNewsFoto/Dermalog Identification ... Used combined in one project, multi-biometric solutions provide a ... ...
Breaking Biology News(10 mins):
(Date:6/20/2017)... NEWTOWN SQUARE, Pa. , June 20, 2017 /PRNewswire/ ... technology, is pleased to announce the issuance of a ... treating gout or hyperuricemia by the U.S. Patent and ... Biotech Inc., a winner of the Buzz of Bio ... , is akin to developing non-drug approaches to ...
(Date:6/20/2017)... ... June 20, 2017 , ... Do More with OHAUS , With the launch ... supplier in the weighing industry, to extending its expertise across the entire laboratory to ... hybridizations and more, allowing for its customers to 'Do More' in the ...
(Date:6/19/2017)... ... June 19, 2017 , ... As ... supporting EDETEK’s products including training, implementation, support, and client process and SOP development. ... He has previously held leadership roles for service providers and top-tier pharmaceuticals, and ...
(Date:6/19/2017)... ... June 19, 2017 , ... Tunnell Consulting ... 50 years. One of the biggest challenges faced by life sciences, biotech and pharmaceuticals ... services team is Kati Abraham , who is well known in the industry ...
Breaking Biology Technology: