Navigation Links
A CNIO study finds a 'molecular scaffolding' that maintains skin structure and organisation
Date:1/16/2014

The human body is daily exposed to external assaults such as bacteria, ultraviolet light or chemical agents. Skin, the largest organ of the body, is the first line of defense against these agents. Skin performs this function thanks to the close connections established between its cells (e.g. adherens junctions). The loss of cell adhesion between these cells is related to inflammatory diseases and cancer, hence the special interest in this area of research over the past years.

A study by the Spanish National Cancer Research Centre (CNIO), featured on the cover of the Journal of Cell Biology, shows how interactions between skin stem cellsthe cells responsible for the constant renewal of skinmaintain the architecture of this organ. "We knew that these junctions were important in skin stem cells but the cellular components involved in their structure and function were not yet understood", says Mirna Prez-Moreno, head of the Epithelial Cellular Biology Group that led the study.

Using skin cells derived from mice, researchers have discovered that one of the key elements in the formation and stabilisation of these junctions are microtubules, tubular structures that are part of all cells and that serve as pillars to maintain their form and function.

"We have seen for the first time that skin stem-cell microtubules connect with cell-cell junctions to form velcro-like structures that hold the cells together", says Marta Shahbazi, a researcher on Prez-Moreno's team and the first author of the study.

The connection between these two cellular componentsmicrotubules and cell-cell junctionsoccurs via the interaction between the CLASP2 and p120 catenin proteins, linked to microtubules and cell junctions respectively.

"We found that the abscence of CLASP2 or p120 catenin in epidermal stem cells caused a loss of their adhesion, and therefore the structure of these cells", says Shahbazi.

"Our results will open up new paths for exploring how these proteins regulate skin physiology", says Prez-Moreno, adding that this knowledge will be "important for the possible development of future regenerative or anti cancer therapies".


'/>"/>

Contact: Nuria Noriega
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert  

Related biology news :

1. Wild sparrow study traces social behaviors in the field to specific gene
2. Illinois study identifies 3 risk factors most highly correlated with child obesity
3. Multiple myeloma study uncovers genetic diversity within tumors
4. Nature study discovers chromosome therapy to correct a severe chromosome defect
5. Study shows large carnivore numbers and range declining worldwide
6. Virginia Tech engineer receives NSF grant to study Colorado flood effects on antibiotic resistance
7. New study: US power plant emissions down
8. Study of Nepalese pilgrims challenges diagnosis of acute mountain sickness
9. New study finds extreme longevity in white sharks
10. Study discovers natural hybridization produced dolphin species
11. Penn biologists establish new method for studying RNAs regulatory footprint
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A CNIO study finds a 'molecular scaffolding' that maintains skin structure and organisation
(Date:4/26/2016)... April 27, 2016 Research ... Multi-modal Biometrics Market 2016-2020"  report to their offering.  ... The analysts forecast the global multimodal ... 15.49% during the period 2016-2020.  Multimodal ... sectors such as the healthcare, BFSI, transportation, automotive, ...
(Date:4/13/2016)... 2016  IMPOWER physicians supporting Medicaid patients in ... clinical standard in telehealth thanks to a new partnership ... platform, IMPOWER patients can routinely track key health measurements, ... index, and, when they opt in, share them with ... a local retail location at no cost. By leveraging ...
(Date:3/22/2016)... , March 22, 2016 ... report "Electronic Sensors Market for Consumer Industry by Type ... Others), Application (Communication & IT, Entertainment, Home ... Global Forecast to 2022", published by MarketsandMarkets, ... expected to reach USD 26.76 Billion by ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... ... ... Cambridge Semantics, the leading provider of Smart Data analytic and data ... to The Silicon Review’s “20 Fastest Growing Big Data Companies of 2016.” , ... of end users facing some of the most complex data challenges in the industry,” ...
(Date:4/27/2016)... ... April 27, 2016 , ... The Pittcon Organizing Committee is pleased to ... been a volunteer member of Committee since 1987. Since then, he has served in ... treasurer and was chairman for both the program and exposition committees. In his professional ...
(Date:4/27/2016)... 27, 2016 NanoStruck Technologies ... NSKQB) ( Frankfurt : 8NSK) gibt ... vom 13. August 2015 die Genehmigung von der ... zusätzliche 200.000.000 Einheiten auf 400.000.000 Einheiten zu erhöhen, ... Davon wurden 157.900.000 Einheiten mit dem ersten Teil ...
(Date:4/27/2016)... ... April 27, 2016 , ... The Board of Directors ... of John Tilton as Chief Commercial Officer.  Mr. Tilton joined Biohaven from Alexion ... commercial leaders responsible for the commercialization of multiple orphan drug indications. Mr. ...
Breaking Biology Technology: