A contest for the best technique of intracellular particle tracking (simultaneous tracking of the motions of hundreds and thousands of intracellular organelles, virions and even individual molecules), that is an important issue in cellular biology and has applications in search for appropriate medicines against certain diseases (including Parkinson's and Alzheimer's diseases), has found no undeniable winner. Techniques proposed by all the participants, including the Lomonosov Moscow State University professor Yannis Kalaidzidis, find their own ways for solving the problem.
The article published in Nature Methods describes not a scientific invention or discovery but the results of a contest of scientific techniques. The task was to find an original solution for a certain scientific problem, and as much as 14 groups from all over the world have taken part. Participants are co-authors of this article, while its leading authors are the organizers. Paper preparation took more than a year: it was accepted in December 2013. The problem itself was formulated in May 2012 in Barcelona during the IEEE International Symposium on Biomedical Imaging (ISBI'12).
"In the live cell imaging there is a not yet completely solved problem of simultaneous tracking of hundreds to thousands of intra-cellular organelles, vesicles, virions and individual fluorescent molecules," - explains one of the participants of the contest, Yannis Kalaidzidis, professor of the Faculty of Bioengineering and Bioinformatics, MSU and research scientist at Max Planck Institute of Molecular Cell Biology and Genetics, Dresden.
Inside the cells, there are numerous vesicles (small intracellular formations, sort of membrane-protected containers inside which nutrients and signaling molecules are stored and transported; viruses and mycobacteria also hijack them to penetrate the cell) responsible for intrac
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Lomonosov Moscow State University