Navigation Links
8 hours of resistance
Date:5/25/2011

Temptations to exceed the speed limit are always plentiful, but only reckless drivers give in to such impulses. Likewise, numerous growth factors always abound in our bodies, but only cancerous cells are quickly "tempted" by these chemicals to divide again and again. Healthy cells, in contrast, divide only after being exposed to growth factors for eight continuous hours. What happens during these eight hours in a healthy cell that resists the call to divide? And even more important, what fails to work properly in the cancerous cell during these same hours? Why do cancerous cells give in so easily to the influence of growth factors, dividing so readily?

Answers to these questions have emerged from a study by a multidisciplinary team of Weizmann Institute researchers published recently in Molecular Cell. The scientists found that when a cell first receives a signal from a growth factor, ten groups of genes, about 8,000 in total, become activated. Of these, one group, consisting of about ten genes governed by the tumor suppressor p53, is the most crucial: These genes prevent the cell from dividing. Only if the growth factor continues to affect the cell for eight hours does p53 release its grip on the cell's DNA, allowing it to divide. Like a careful driver who puts the brakes on before proceeding, the activation of p53 at the time the cell receives a growth factor signal serves as a "brake," preventing instant division. In this manner, the healthy cell ensures that it will not divide as a result of accidental, mistaken or otherwise superfluous growth signals, but only if the signal is continuous and necessary. In cancerous cells, this mechanism malfunctions because in most of them, p53 is defective or missing altogether, so that even a fleeting growth signal can cause them to divide, leading to cancerous growth.

This interdisciplinary study has resulted from a collaboration between three research teams at the Weizmann Institute, headed by Prof. Yosef Yarden of the Biological Regulation Department, Prof. Eytan Domany of the Physics of Complex Systems Department and Prof. Moshe Oren of the Molecular Cell Biology Department. The study was coordinated by former graduate student Dr. Yaara Zwang; taking part were Aldema Sas-Chen, Yotam Drier, Dr. Tal Shay, Roi Avraham, Dr. Mattia Lauriola, Efrat Shema and Efrat Lidor-Nili. Also taking part were clinical researchers: Dr. Jasmine Jacob-Hirsch, Dr. Ninette Amariglio and Prof. Gideon Rechavi of the Chaim Sheba Medical Center and Drs. Yiilng Lu and Gordon B. Mills of the M.D. Anderson Cancer Center at the University of Texas.

This research sheds new light on the differences between healthy and cancerous cells. It might help develop new effective approaches to chemotherapy. Cancerous tumors sometimes develop resistance to the therapy, among other reasons because it stresses the body. The stress, in turn, leads to the production of growth factors that cause cells to divide, so that the treatment ultimately defeats itself. A better understanding of how growth factors work can help identify intervals for chemotherapy that will prevent the increased division of cancerous cells.


'/>"/>

Contact: Yivsam Azgad
news@weizmann.ac.il
972-893-43856
Weizmann Institute of Science
Source:Eurekalert

Related biology news :

1. Not enough hours in the day for endangered apes
2. Over two billion hours served
3. New LLNL detection technology identifies bacteria, viruses, other organisms within 24 hours
4. DOE awards over a billion supercomputing hours to address scientific challenges
5. Molecular technique advances soybean rust resistance research
6. Study shows corn gene provides resistance to multiple diseases
7. Drug-resistance fears for deadly fungal disease
8. Lawn of native grasses beats traditional lawn for lushness, weed resistance
9. Older and stronger: Progressive resistance training can build muscle, increase strength as we age
10. Kentucky researchers find a key to plant disease resistance
11. Economics and evolution help scientists identify new strategy to control antibiotic resistance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/16/2016)... June 16, 2016 The ... expected to reach USD 1.83 billion by 2024, ... Research, Inc. Technological proliferation and increasing demand in ... expected to drive the market growth. ... The development of advanced multimodal techniques for ...
(Date:6/3/2016)... 2016 Das DOTM ... Nepal hat ein 44 Millionen ... Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, an ... und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte internationale ... teilgenommen, aber Decatur wurde als konformste und ...
(Date:5/24/2016)... facilitates superior patient care by providing unparalleled technology to leaders of the medical imaging ... product recently added to the range of products distributed by Ampronix. Photo ... ... ... News ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... , ... Researchers at the Universita Politecnica delle Marche in Ancona combed medical ... mesothelioma. Their findings are the subject of a new article on the Surviving Mesothelioma ... in the blood, lung fluid or tissue of mesothelioma patients that can help point ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... is pleased to announce the launch of their brand, UP4™ Probiotics, into Target ... over 35 years, is proud to add Target to its list of well-respected ...
(Date:6/23/2016)... June 23, 2016 /PRNewswire/ - FACIT has announced ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" ... commercialization of a portfolio of first-in-class WDR5 inhibitors ... such as WDR5 represent an exciting class of ... precision medicine for cancer patients. Substantial advances have ...
(Date:6/23/2016)... , June 23, 2016 Houston ... with the Cy-Fair Sports Association to serve as ... the agreement, Houston Methodist Willowbrook will provide sponsorship ... and connectivity with association coaches, volunteers, athletes and ... with the Cy-Fair Sports Association and to bring ...
Breaking Biology Technology: