A two-year fellowship at the National Institutes of health early in Lefkowitz's career sparked his interest in receptor biology, a field that was then in its infancy. At that time, experiments in other laboratories had only suggested the presence of cell receptors, but no one had ever proved their existence. Lefkowitz was convinced they were real, and he set out to isolate them. He also discovered two new families of proteins that desensitize G protein-coupled receptors-a finding that has helped scientists understand, in molecular terms, how receptors become tolerant to certain drugs and may eventually lead to new treatments for human diseases, including heart failure.
From Columbia University, Lefkowitz received his B.A. in Chemistry as well as his M.D.
Bert W. O'Malley - Baylor College of Medicine
For his pioneering work on the molecular mechanisms of steroid hormone action and hormone receptors and coactivators, which has had a profound impact on our knowledge of steroid hormones in normal development and in diseases, including cancer.
Bert O'Malley is currently the Tom Thompson Distinguished Service Professor of Molecular and Cellular Biology at Baylor College of Medicine where he built one of the finest departments in the country over the last thirty years. The department was one of the first of a new generation of departments which combined the merging disciplines of cell structure, molecular biology, and developmental biology into a unified Department of Molecular and Cellular Biology.
His laboratory group is interested in determining the fundamental mechanisms for regulation of eukaryotic gene expression. Their early work defined the "primary molecular endocrine pathway" by
|Contact: Lisa-Joy Zgorski|
National Science Foundation