Navigation Links
70 years old and going strong with Down syndrome and no dementia
Date:9/9/2008

own syndrome over 75 years of age have found that they usually do not have typical Down syndrome, which 'Mr. C' does. That is, these previous cases did not have three complete copies of Chromosome 21 throughout all the cells in their bodies, but had an atypical Down syndrome genotype, explaining why they may have been less severely affected and why they had a higher life expectancy. However, 'Mr. C' is aging successfully despite having complete Trisomy 21, making this the first case of its kind reported in scientific literature.

"The understanding in the field [until] very recently was that if you had Down syndrome and were lucky enough to make it to 70 years of age, then you would have to have Alzheimer's disease," explains Wayne Silverman, the study's co-author and Director of Intellectual Disabilities Research at the Kennedy Krieger Institute in Baltimore. "But now, we have 'Mr. C', who clearly contradicts this longstanding assumption and offers a new benchmark and tremendous hope for all people with Down Syndrome to live longer and healthier lives."

The processes regulating aging and dementia are complex and it is unlikely that any single mechanism can fully explain the array of changes that occur with aging. While future research could take several directions, including studies of risk factors like cholesterol or the bio availability of estrogen, Silverman explains that the area of gene expression offers promise at this time. While an extra copy of Chromosome 21 in a person causes an overabundance of some proteins, one possible explanation for 'Mr. C''s successful aging and increased life expectancy is that, for one reason or another, he does not actually have an overexpression of all the genetic material that comes along with his extra copy of Chromosome 21.


'/>"/>

Contact: Anu Prabhala
annap@aaidd.org
202-387-1968
American Association on Intellectual and Developmental Disabilities
Source:Eurekalert

Page: 1 2

Related biology news :

1. First orchid fossil puts showy blooms at some 80 million years old
2. ESA celebrates 100 years of insect science journals
3. Researchers detect hint of oxygen 50 to 100 million years earlier than first believed
4. The benefits of 80 million years without sex
5. Researchers find origin of breathable atmosphere half a billion years ago
6. Fossil record reveals elusive jellyfish more than 500 million years old
7. Rodent fossils allows to determine climate of the Iberian Peninsula 6 million years ago
8. Atomic bomb survivor, scientists mark 60 years of long-term radiation study
9. Molecular Biology of the Cell celebrates 25 years of publication
10. 4 health behaviors can add 14 extra years of life
11. After more than 100 years apart, webworms devastate New Zealand parsnips
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... 18, 2014 Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) ... North America Perimeter Security Systems Market" report to their ... The North American perimeter security market is estimated to grow ... the U.S. market holds a larger share in this market, ...
(Date:12/17/2014)... FORT BELVOIR, Va. , Dec. 15, 2014 ... make it easier to detect and prevent counterfeit microcircuits ... the agency started performing an in-house microcircuit anti-counterfeit initiative ... of purchased microcircuits while increasing their reliability throughout the ...
(Date:12/17/2014)... 16, 2014  Automation is fundamentally transforming the travel experience ... borders. Over the past decade, ePassports, biometric readers, and ... process through border control via eGates and Automated Passport ... seaports, and land borders across the globe. ...
Breaking Biology News(10 mins):Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2
... mysterious island that moves through time. Travelers in search ... fiction television show "Lost," but it also describes a ... students. Iris Totten, an associate professor of geology ... professor of geology at University of Missouri at Kansas ...
... A first of its kind study examining the effects of ... cause abnormal brain development in children. The research is published ... , the medical journal of the American Academy of Neurology. ... women of childbearing age, leading to an increasing number of ...
... are less likely to use folic acid supplements before ... immigrated to the country, according to a new study ... with Statistics Canada, Health Canada and the University of ... estimates of pre-pregnancy folic acid use in Canada. ...
Cached Biology News:K-State using Second Life island to help high school students learn earth science 2Prenatal meth exposure linked to abnormal brain development 2Immigrant women may be at higher risk of having a baby with a birth defect 2
(Date:1/22/2015)... 22, 2015 Selexis SA, a serial ... Cell Banks (RCBs) used for drug discovery to commercial ... will include Next-Generation Sequencing (NGS) data packages. ... biologic manufacturing by ensuring the integrity of the gene, ...
(Date:1/22/2015)... , Jan. 22, 2015   GenoSpace , a precision ... tools to enable the broad use of genomic, imaging and ... the appointment of Michelle Munson , CEO of Aspera, ... Logo - http://photos.prnewswire.com/prnh/20150122/170713 ...
(Date:12/24/2014)... AUSTIN, Texas , Dec. 24, 2014  Vermillion, ... focused on gynecologic disease, announced today that the ... investors including Oracle Investment Management, Jack W. ... directors. Total proceeds were $10.5 million, before offering ...
(Date:12/24/2014)... BOSTON, MA (PRWEB) December 23, 2014 ... series is designed to introduce cutting edge communication ... partners of platform upgrades. This webinar series demonstrates ... their quest to leverage web conferencing’s most innovative ...
Breaking Biology Technology:Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2GenoSpace Expands Board with Appointment of Michelle Munson 2Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3
... ... present at the Process Expo 2010 in Chicago from July 18 – ... and manufacturing of industrial wastewater treatment systems for the food processing industry. ... and that FRC is a major well-known and respected DAF (Dissolved Air ...
... Talecris Biotherapeutics Holdings Corp. (Nasdaq: TLCR ) today ... as vice president, U.S. Product Management.  In this role, Morgan will ... product portfolio in the U.S. , ... "Lafmin brings significant experience and leadership to ...
... Bion Environmental Technologies, Inc. (OTC Bulletin Board: BNET) today ... July 14 , hosted by SUNY Oswego ,s Office ...  The forum, sought by Bion along with Operation Oswego, ... beef cattle production facility that would be integrated with beef ...
Cached Biology Technology:FRC Systems International State-of-the-art Industrial Wastewater Treatment Systems 2FRC Systems International State-of-the-art Industrial Wastewater Treatment Systems 3Lafmin Morgan Joins Talecris Biotherapeutics as Vice President, U.S. Product Management 2Bion Confirms Participation in SUNY Oswego's Forum 2Bion Confirms Participation in SUNY Oswego's Forum 3Bion Confirms Participation in SUNY Oswego's Forum 4
... Leukemia Virus Reverse Transcriptase (M-MLV RT) is an ... cDNA synthesis with long messenger RNA templates (>5kb). ... gene of M-MLV and consists of a single ... RNase H activity of M-MLV RT is weaker ...
... ds Qualified is a special preparation of bovine ... double stranded cleavage of DNA molecules. In the ... enzyme makes double strand breaks at random sites ... fragments can be controlled by the enzyme concentration ...
...
p230 trans Golgi Purified Anti-Human clone 15, Isotype Mouse IgG 1 , 50 µg Consult technical datasheet for details....
Biology Products: