Navigation Links
660 nm red light-enhanced BMSCs transplantation for hypoxic-ischemic brain damage
Date:4/9/2014

A series of previous studies suggested that the neuronal differentiation rate of bone marrow mesenchymal stem cells during the in vitro culture reached 78-92%, but their in vivo transplantation efficiency, and survival and differentiation rates were very low. The low levels of bone marrow mesenchymal stem cell transplantation, survival, colonization and differentiation efficacy greatly restrict their therapeutic effect. Red or near-infrared light from 600-1,000 nm promotes cellular migration and prevents apoptosis. Thus, Dr. Xiaoying Wu and co-workers from Chongqing University in China hypothesized that the combination of red light with bone marrow mesenchymal stem cell transplantation would be effective for the treatment of hypoxic-ischemic brain damage. They found that, after a 40-hour irradiation under red light-emitting diodes at 660 nm and 60 mW/cm2, an increasing number of green fuorescence-labeled bone marrow mesenchymal stem cells migrated towards hypoxic-ischemic damaged primary neurons. Meanwhile, neonatal rats with hypoxic-ischemic brain damage were given an intraperitoneal injection of 1 106 bone marrow mesenchymal stem cells, followed by irradiation under red light-emitting diodes at 660 nm and 60 mW/cm2 for 7 successive days. Shuttle box test results showed that, after phototherapy and bone marrow mesenchymal stem cell transplantation, the active avoidance response rate of hypoxic-ischemic brain damage rats was significantly increased, which was higher than that after bone marrow mesenchymal stem cell transplantation alone. Experimental findings, published in the Neural Regeneration Research (Vol. 9, No. 3, 2014), indicate that 660 nm red light emitting diode irradiation promotes the migration of bone marrow mesenchymal stem cells, thereby enhancing the contribution of cell transplantation in the treatment of hypoxic-ischemic brain damage


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert  

Page: 1

Related biology news :

1. New insights into facial transplantation
2. Harvard scientists control cells following transplantation, from the inside out
3. Combination of cell transplantation and gene therapy for Alzheimers disease
4. Liver cells benefit from mesenchymal stem cell co-culture prior to transplantation
5. Researchers describe 1 mechanism that favors rejection in transplantation of porcine cartilage in humans
6. New research on inherited herpesvirus may have implications for transplantation
7. Mesenchymal stem cell transplantation may heal a mothers childbirth injury
8. Fetal stem cell transplantation favorably impacts radiation-induced cognitive dysfunction
9. Melatonin pre-treatment is a factor that impacts stem cell survival after transplantation
10. New protocol developed to decontaminate human fetal tissues used for cell transplantation
11. Environmental enrichment important factor impacting cell transplantation and brain repair
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
660 nm red light-enhanced BMSCs transplantation for hypoxic-ischemic brain damage
(Date:11/14/2016)... Calif. , Nov. 14, 2016 /PRNewswire/ ... biometric identification market, Frost & Sullivan recognizes ... & Sullivan Award for Visionary Innovation Leadership. ... in the biometric identification market by pioneering ... verification solution for instant, seamless, and non-invasive ...
(Date:6/22/2016)... BETHESDA, Md. , June 22, 2016  The American ... by Trade Show Executive Magazine as one of ... Summit on May 25-27 at the Bellagio in ... based on the highest percentage of growth in each of ... number of exhibiting companies and number of attendees. The 2015 ...
(Date:6/22/2016)... 22, 2016 On Monday, the Department of ... to share solutions for the Biometric Exit Program. The ... Border Protection (CBP), explains that CBP intends to add ... the United States , in order to ... imposters. Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
Breaking Biology News(10 mins):
(Date:12/9/2016)... , Dec. 9, 2016  A platform of ... are moving one step closer to becoming viable ... OrthoMend Research, Inc., a start-up company from ... exclusive license for these novel absorbable bone fixation ... them for commercial use. The company has leased ...
(Date:12/9/2016)... /PRNewswire/ - Portage Biotech Inc. ("Portage" or "the Company") ... announce that Biohaven has issued today the following press ... (PRWEB) Dec 9, 2016 - Biohaven Pharmaceutical Holding ... the U.S. Food and Drug Administration ("FDA") has granted ... candidate BHV-0223, an orally dissolving tablet being developed for ...
(Date:12/8/2016)... Dec. 8, 2016  The Board of Directors of ... Western Pennsylvania,s only pure life sciences ... accordance with the succession plan developed by the Nominating ... today, James (Jim) F. Jordan is selected ... John W. Manzetti , who is elected to ...
(Date:12/8/2016)... (PRWEB) , ... December 08, 2016 , ... Lajollacooks4u, San ... a banner year for team building events, new program offerings and company expansion. ... expanded earlier this year to include groups of over 30 people. Ever since, Lajollacooks4u ...
Breaking Biology Technology: