Navigation Links
660 nm red light-enhanced BMSCs transplantation for hypoxic-ischemic brain damage
Date:4/9/2014

A series of previous studies suggested that the neuronal differentiation rate of bone marrow mesenchymal stem cells during the in vitro culture reached 78-92%, but their in vivo transplantation efficiency, and survival and differentiation rates were very low. The low levels of bone marrow mesenchymal stem cell transplantation, survival, colonization and differentiation efficacy greatly restrict their therapeutic effect. Red or near-infrared light from 600-1,000 nm promotes cellular migration and prevents apoptosis. Thus, Dr. Xiaoying Wu and co-workers from Chongqing University in China hypothesized that the combination of red light with bone marrow mesenchymal stem cell transplantation would be effective for the treatment of hypoxic-ischemic brain damage. They found that, after a 40-hour irradiation under red light-emitting diodes at 660 nm and 60 mW/cm2, an increasing number of green fuorescence-labeled bone marrow mesenchymal stem cells migrated towards hypoxic-ischemic damaged primary neurons. Meanwhile, neonatal rats with hypoxic-ischemic brain damage were given an intraperitoneal injection of 1 106 bone marrow mesenchymal stem cells, followed by irradiation under red light-emitting diodes at 660 nm and 60 mW/cm2 for 7 successive days. Shuttle box test results showed that, after phototherapy and bone marrow mesenchymal stem cell transplantation, the active avoidance response rate of hypoxic-ischemic brain damage rats was significantly increased, which was higher than that after bone marrow mesenchymal stem cell transplantation alone. Experimental findings, published in the Neural Regeneration Research (Vol. 9, No. 3, 2014), indicate that 660 nm red light emitting diode irradiation promotes the migration of bone marrow mesenchymal stem cells, thereby enhancing the contribution of cell transplantation in the treatment of hypoxic-ischemic brain damage


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert  

Page: 1

Related biology news :

1. New insights into facial transplantation
2. Harvard scientists control cells following transplantation, from the inside out
3. Combination of cell transplantation and gene therapy for Alzheimers disease
4. Liver cells benefit from mesenchymal stem cell co-culture prior to transplantation
5. Researchers describe 1 mechanism that favors rejection in transplantation of porcine cartilage in humans
6. New research on inherited herpesvirus may have implications for transplantation
7. Mesenchymal stem cell transplantation may heal a mothers childbirth injury
8. Fetal stem cell transplantation favorably impacts radiation-induced cognitive dysfunction
9. Melatonin pre-treatment is a factor that impacts stem cell survival after transplantation
10. New protocol developed to decontaminate human fetal tissues used for cell transplantation
11. Environmental enrichment important factor impacting cell transplantation and brain repair
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
660 nm red light-enhanced BMSCs transplantation for hypoxic-ischemic brain damage
(Date:3/31/2016)...   LegacyXChange, Inc. ... LegacyXChange is excited to release its first ... be launched online site for trading 100% guaranteed authentic ... also provide potential shareholders a sense of the value ... industry that is notorious for fraud. The video is ...
(Date:3/22/2016)... and SANDY, Utah , ... which operates the highest sample volume laboratory in ... Genomics and UNIConnect, leaders in clinical sequencing informatics and ... launch of a project to establish the informatics infrastructure ... NSO has been contracted by the Ontario ...
(Date:3/15/2016)... JERUSALEM , March 15, 2016 ... Jerusalem , the technology-transfer company of the Hebrew University, ... developer of remote sensing technology of various human biological ... funding, raising $2.0 million from private investors. ... technology, based on the detection of electromagnetic emissions from ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... ... April 29, 2016 , ... ... pain medicine, is excited to announce the launch of the Proove Health ... studies, volunteerism, and education to promote the use of personalized medicine for tackling ...
(Date:4/29/2016)... ALBANY, New York , April 29, 2016 ... market report published by Transparency Market Research "Separation ... Analysis, Size, Share, Growth, Trends, and Forecast 2015 ... market was valued at US$ 10,665.5 Mn in ... CAGR of 6.8% from 2015 to 2023 to ...
(Date:4/29/2016)... ... 29, 2016 , ... Summit for Stem Cell has received a $250,000 grant ... stem cell therapy for the treatment of Parkinson’s disease. The Summit research project is ... Scripps Research Institute in San Diego, CA. , The aim of of ...
(Date:4/29/2016)... -- Elekta is pleased to announce that ... treatment planning software, is available for clinical release. Real-world ... version 5.11 provides significant performance speed enhancements over prior ... four times faster than in previous versions of ... Monte Carlo algorithm, users can ...
Breaking Biology Technology: