Navigation Links
50-year search for calcium channel ends
Date:6/19/2011

Boston, MA (June 19, 2011)Mitochondria, those battery-pack organelles that fuel the energy of almost every living cell, have an insatiable appetite for calcium. Whether in a dish or a living organism, the mitochondria of most organisms eagerly absorb this chemical compound. Because calcium levels link to many essential biological processesnot to mention conditions such as neurological disease and diabetesscientists have been working for half a century to identify the molecular pathway that enables these processes.

After decades of failed effort that relied on classic biochemistry and membrane protein purification, Vamsi Mootha, HMS associate professor of systems biology, and colleagues have discovered, through a combination of digital database mining and laboratory assays, the linchpin protein that drives mitochondria's calcium machinery.

"This channel has been studied extensively using physiology and biophysics, yet its molecular identity has remained elusive," said Mootha, who also has appointments at Massachusetts General Hospital and at Broad Institute. "But thanks to the Human Genome Project, freely downloadable genomic databases, and a few tricks -- we were able to get to the bottom of it."

These findings will appear online June 19 in Nature.

The results build on work from Vamsi and his group over the past decade. In 2008, he and his team published a near-comprehensive protein inventory, or proteome, of human and mouse mitochondria. This inventory, called MitoCarta, consisted of just over 1,000 proteins, most of which had no known function.

In a September 2010 paper, Mootha's group described using the MitoCarta inventory to identify the first protein specifically required for mitochondrial calcium uptake. Their strategy was simple. They knew that mitochondria from humans and Trypanosomes (a parasitical organism), but not baker's yeast, are capable of absorbing large amounts of calcium. By simply overl
'/>"/>

Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. National report shines light on lupus 50-year treatment drought
2. Ecologists find new clues on climate change in 150-year-old pressed plants
3. Wistar Institute researcher receives New Innovator award from NIH
4. NC State researchers get to root of parasite genome
5. White Mountain Research Station to host climate change conference
6. Stevens awarded $1M for advanced biofuels research
7. Researchers find animal with ability to survive climate change
8. Researchers find an essential gene for forming ears of corn
9. Researchers note differences between people and animals on calorie restriction
10. Researcher working on destruction of chemical weapons
11. Researchers study acoustic communication in deep-sea fish
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... before humans figured out how to create colors, nature ... butterfly wings of many different hues, for example. Now ... more environmentally friendly way to make colored plastics. Their ... architectures of materials rather than dyes, to produce ... . , N. Asger Mortensen, Anders Kristensen and colleagues ...
(Date:7/30/2014)... has been awarded the Scientific Committee on Antarctic ... Research. , SCAR, an inter-disciplinary international science body, ... research in the Antarctic region, and on the ... system. The organisation also provides scientific advice about ... governing the region. , The medal is open ...
(Date:7/30/2014)... 3,000 pieces is still in its infant stage. But ... of major significance. "Amazingly often, we are findingin addition ... that we found in Baltic amber," explained Bonn paleontologist ... comes from the Baltic Sea region, which is almost ... e.g., the coastal regions of Mecklenburg, Poland and Belarus. ...
Breaking Biology News(10 mins):Chinese mosquitos on the Baltic Sea 2
... Bonn Institute for Forensic Medicine has recorded that the ... sexual offences within their catchment area increased 10-fold between ... Deutsches rzteblatt International, Burkhard Madea and Frank Musshoff ... for the most frequent substances ( Dtsch Arztebl Int ...
... should be built in Lund, Sweden, it has been announced ... last night (28 May), seven countries voted in support of ... a further two voting with the majority. The European ... for materials research, enabling scientists to study the atomic and ...
... of a USC-led research team say they,ve made a big ... and other biological materials one that may be a ... of a piece of synthetic antibody attached to a nanowire ... If the protein the antibody binds to is present in ...
Cached Biology News:Sweden to host 1.3 billion Euro research center 2A quicker, cheaper SARS virus detector -- one easily customizable for other targets 2
(Date:7/30/2014)... East Hartford, CT (PRWEB) July 30, 2014 ... non-profit economic development organization based in East Hartford, Conn., ... work on Phase II of a project that will ... facility in rural north-central Connecticut. USDA Rural Development ... Grant (RBEG) program for the second phase of the ...
(Date:7/30/2014)... July 30, 2014 Immunology ... leading Immunologists, Principle Investigators, scientists in the field, ... Malemud, Professor at Case Western Reserve University School ... keynote address on “The effects of recombinant ... of matrix metalloproteinase-9”. Arya Biragyn, a Senior investigator ...
(Date:7/29/2014)... Dallas, Texas (PRWEB) July 30, 2014 ... in Private Equity and Venture Capital Funding” report ... factors shaping the private equity and venture capital ... that these are expected to have significant impact ... the US and globally. Furthermore, the report identifies ...
(Date:7/29/2014)... July 29, 2014   Sequenom, Inc. (NASDAQ: ... provides innovative genetic analysis solutions, and Mayo Medical ... services in the United States , ... patents and applications. "We have great appreciation ... care, and we welcome the opportunity to partner with ...
Breaking Biology Technology:USDA Grant Funds Second Phase of Bio-Energy Research Community Economic Development in CT 2USDA Grant Funds Second Phase of Bio-Energy Research Community Economic Development in CT 3Unveiling Breakthroughs in Clinical & Cellular Immunology 2Unveiling Breakthroughs in Clinical & Cellular Immunology 3Strategic Trends of Biotech Investment Industry (Private Equity and Venture Capital Funding) in New Report Available at MarketOptimizer.org 2Strategic Trends of Biotech Investment Industry (Private Equity and Venture Capital Funding) in New Report Available at MarketOptimizer.org 3Strategic Trends of Biotech Investment Industry (Private Equity and Venture Capital Funding) in New Report Available at MarketOptimizer.org 4Sequenom Enters Into License Agreement With Mayo Medical Laboratories 2Sequenom Enters Into License Agreement With Mayo Medical Laboratories 3Sequenom Enters Into License Agreement With Mayo Medical Laboratories 4
... June 16 On Wednesday, June 23 , a free, interactive ... renewed hope for new jobs in Ohio . Nine experts in the ... on innovation, global commerce and the new skills needed for a new economy ... , , ...
... Inc. (Nasdaq: NBIX ) announced today that the Company will host a ... worldwide development and commercialization of elagolix and the next-generation GnRH antagonists. , ... The live conference call and webcast will ... Eastern Time ( 5:45 a.m. Pacific Time ).  Participants can access the ...
... ... has announced the release of iC Kinetics software. iC Kinetics software ... a kinetic model that describes the influence of various experimental parameters ... be used to simulate the effect of concentration and temperature on ...
Cached Biology Technology:Free Web Cast On Fueling Ohio's New Job Growth 2Neurocrine Biosciences Announces Conference Call and Webcast on Worldwide Agreement With Abbott on Elagolix 2A Faster Way to Understand and Optimize your Chemistry 2
... the value of your microarray data ... the support you need from consultation ... most up to date methods. Utilize ... Gene Expression Profiling Service or from ...
... of your microarray data using Asuragens bioinformatics ... from consultation to extensive data analysis using ... our expertise in combination with the Gene ... microarray experiments., ,Normalization and basic statistical analysis ...
... number is a new product ... Cornings product number. If showing ... under the old Sigma-Aldrich number ... for assistance. Material: cap ...
BD Falcon 850 cm Smooth-surface TufRol Roller Bottle, tissue-culture treated polystyrene, blow-molded one-piece design, with easy on/off non-vented cap, packed in double bag. (20/ca) Packaging: ...
Biology Products: